Clinical trials: Perioperative Hyperglycaemia
Perioperative Hyperglycaemia, Insulin Therapy
Fully Closed-Loop Insulin Delivery in Abdominal Surgery (CLAB)
The purpose of the study is to assess the efficacy, safety and usability of perioperative fully-automated closed-loop insulin delivery versus standard insulin therapy in patients with diabetes other than type 1 diabetes…
- Conditions
- Perioperative Hyperglycaemia, Insulin Therapy, Elective Surgery, Closed-Loop Glucose Control
- Trial name
- CLAB (NCT05392452)
- Testing
- CamAPS HX, Standard insulin therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 38 people
- Sponsor
- Lia Bally
Hyperglycemia
PGMP for Alberta Surgical Patients
Patients with postoperative hyperglycemia have higher complication rates and worse outcomes than patients with in-target glucose, including longer length-of-stay, more admissions to intensive care, increased readmission rates…
- Trial name
- NCT05036655
- Testing
- Perioperative glycemic management pathway
- Where
- 2 sites in Canada
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stress Hyperglycemia
Exenatide for Stress Hyperglycemia
Stress hyperglycemia is a common phenomenon in cardiac surgery that concerns diabetic and non diabetic patients. It has been shown that perioperative hyperglycemia is an independent risk factor of postoperative mortality and…
- Trial name
- ExSTRESS (NCT01969149)
- Testing
- Exenatide, Insulin
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Prediabetes or Diabetes, Surgery Complications
The Prevalence of Hyperglycemia in Surgical Patients With Pre-diabetes
The goal of this study is to measure the prevalence and risks of hyperglycemia in surgical patients with prediabetes. The main questions it aims to answer are: What is the prevalence of hyperglycemia in surgical patients with…
- Conditions
- Prediabetes or Diabetes, Surgery Complications, Non-Cardiac/ Non-Thoracic Surgery, Stress Hyperglycemia
- Trial name
- NCT07662980
- Where
- Canada
- Volunteers
- 750 people
- Sponsor
- University of Calgary
Hyperglycemia, Hypoglycemia
GLP 1 for Intraoperative Glycemic Control
This is a medical research study designed to see if an infusion of a naturally occurring hormone, GLP-1, works when used to decrease blood sugar during cardiac surgery.
- Trial name
- GLP (NCT00882492)
- Testing
- GLP 1
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Hyperglycemia, Metformin
Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery
Evaluation of the effect of peri-operative continuation of oral metformin therapy on the incidence of perioperative hyperglycemia compared to standard preoperative cessation of oral metformin therapy 24h before surgery.
- Conditions
- Hyperglycemia, Metformin, Type 2 Diabetes, Hyperlactatemia
- Trial name
- NCT04284722
- Testing
- Metformin Hydrochloride
- Volunteers
- 400 people
- Sponsor
- Kepler University Hospital
Euglycemia, Hypoglycemia
Intravenous Exenatide (Byetta) During Surgery
The purpose of this project is to study if intravenous Exenatide is effective at maintaining normal blood glucose levels and preventing low blood glucose levels during surgery.
- Conditions
- Euglycemia, Hypoglycemia, Hyperglycemia
- Trial name
- NCT00882050
- Testing
- Exenatide 0.27 ng/kg/min, Exenatide 0.41 ng/kg/min
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Thomas Jefferson University
Hyperglycemia
Computerized Tight Glycemic Control in Cardiac Surgery
The debate about tight glycemic control (TGC) in the operating room and on the intensive care unit is ongoing, especially in cardio-surgical patients treated with blood cardioplegia, due to high blood glucose levels during…
- Trial name
- NCT01886365
- Testing
- Space GlucoseControl System, B. Braun, Melsungen, Germany, Conventional therapy with a fixed insulin dosing scheme
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hyperglycemia Stress
TIVA and VIMA on Blood Glucose and Insulin Levels in Lung Lobectomy Patients
The purpose of this study was to evaluate the efficacy and safety of sevoflurane-only Volatile induction and maintenance anesthesia (VIMA) and total intravenous anesthesia (TIVA) using only propofol in adult patients scheduled…
- Trial name
- NCT03094533
- Testing
- TIVA, VIMA
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yeungnam University College of Medicine
General Anesthesia, Hyperglycemia
Can Blood Glucose Levels During the Perioperative Period Identify a Population at Risk for Hyperglycemia?
Surgery performed during general anesthesia induces a stress effect on the body. Our plan is to identify population at risk of hyperglycemia during perioperative period.
- Trial name
- NCT00468494
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Hyperglycemia, Perioperative Complication
Effect of Perioperative Glycemia Protocol on Glycemic Outcomes in Diabetic Patients Undergoing Abdominal Surgery
This study evaluated to the effects of a glycaemic control protocol directed by nurses during the perioperative period on glycaemic outcomes in diabetic patients undergoing major abdominal surgery.
- Trial name
- NCT04167410
- Testing
- glycaemic management protocol implemented to clinic
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Hyperglycemia Stress
Perioperative Stress Hyperglycemia in General and Vascular Surgery Patients
Hyperglycemia is seen in approximately 30% of patients who do not have a history of diabetes and undergo general surgery. Hyperglycemia in this setting is associated with increased risk of postoperative complications.
- Trial name
- NCT04862234
- Testing
- Dulaglutide, Continuous glucose monitor (CGM), blinded
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Emory University
Poor Glycemic Control
Efficacy and Safety of a Glargine-based Hospital Discharge Algorithm in Coronary Artery Bypass Graft (CABG) Patients
Most coronary artery bypass graft surgery (CABG) patients develop high blood sugar while they are in the hospital. No studies have shown what the best insulin regimen is for CABG patients with type 2 diabetes is after going home…
- Trial name
- CABG-D/C (NCT01792830)
- Testing
- Metformin, Glargine insulin, Glulisine
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- Emory University
Glucose Metabolism Disorders, Perioperative Care
Accuracy and Safety of Real Time Continuous Glucose Monitoring Before, During and After Surgery
The purpose of this study is to determine the safety and accuracy of the Real-Time Continuous Glucose monitoring System (RT-CGMS)in measuring glucose in patients scheduled for surgery; before, during and after surgery.
- Trial name
- GluContinu (NCT00464529)
- Testing
- Real-Time Continuous Glucose monitoring System (RT-CGMS)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Research Foundation, The Netherlands
Surgery, Anesthesia
A Natural History of Perioperative Metabolism
The process of surgery is a controlled trauma to the body. Trauma induces changes in metabolic function that have evolved to help the body survive injury.
- Conditions
- Surgery, Anesthesia, Insulin Sensitivity, Metabolic Stress Hyperglycemia
- Trial name
- NCT04396964
- Volunteers
- 19 people
- Sponsor
- University of Vermont Medical Center
Perioperative and Postoperative Hyperglycemia, Tight Glycemia Control
Perioperative Versus Postoperative Glycemia Control in Cardiac Surgery Patients
It is known that acute stress of organism often leads to hyperglycemia even in nondiabetic patients. It is also known that pathophysiological mechanisms: enhanced gluconeogenesis, impaired insulin secretion and decreased insulin…
- Trial name
- NCT01548963
- Testing
- Intensive glycemia control
- Where
- Czechia
- Volunteers
- 2,384 people
- Sponsor
- Charles University, Czech Republic
Surgical Site Infections, Stress Hyperglycemia
Perioperative Glucose Monitoring and Treatment to Reduce Risk of Surgical Site Infections and Complications
This study is to determine if glucose monitoring and treatment in surgical procedures over 2 hours help to decrease the surgical site infection risk and reduce postoperative complications.
- Trial name
- POGM (NCT06765655)
- Testing
- Insulin Lispro Injection, glucose testing
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- St. Peter's Hospital, Albany, NY
Hyperglycaemia During Perioperative Period, Heart Valve Diseases
Glucose Control in Open Heart Surgery
The purpose of the study is to seek if there is difference to state glucose level in 80-120mg/dl or 200mg/dl in patients submitted to open heart surgery
- Conditions
- Hyperglycaemia During Perioperative Period, Heart Valve Diseases, Ventricular Dysfunction
- Trial name
- NCT00370643
- Testing
- human regular insulin
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo
Hyperglycaemia, Total Gastrectomy
The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy
Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality.
- Conditions
- Hyperglycaemia, Total Gastrectomy, Anastomotic Leaks
- Trial name
- NCT07140991
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Taner Abdullah
Colorectal (Colon or Rectal) Cancer, STOMACH NEOPLASM
Perioperative Biomarkers in Colorectal and Gastric Cancer Surgery
This study aims to evaluate whether monitoring perioperative inflammatory and metabolic biomarkers can help identify postoperative complications early in adult patients undergoing colorectal or gastric cancer surgery.
- Trial name
- PERIO-BIO (NCT07881133)
- Testing
- Perioperative Biomarker-Guided Monitoring
- Where
- Romania
- Volunteers
- 320 people
- Sponsor
- Bucharest Emergency Hospital