Clinical trials: Perioperative Myocardial Infarction
Coronary Artery Disease, Acute Coronary Syndrome
Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome
The present study seeks to evaluate the effectiveness of the use of perioperative colchicine with regard to operative complications, in patients with acute coronary syndrome and indication for cardiac post-surgical…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Coronary Artery Bypass, Myocardial Reperfusion
- Trial name
- COCAR (NCT05726019)
- Testing
- Colchicine
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Elective Non-cardiac Surgery
Leukocytes and Perioperative Cardio Vascular Events
To analyze whether non-cardiac surgery in high-risk cardio-vascular patients induces a quantitative change in one or several leukocyte subpopulations and whether such changes are associated with perioperative cardio-vascular…
- Trial name
- LeukoCAPE (NCT02874508)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Heidelberg
Perioperative Myocardial Infarction, Perioperative Myocardial Injury
Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction/Injury After Noncardiac Surgery
The goal of this observational prospective cohort study is to learn about the pathophysiology of perioperative myocardial infarction/injury in high-risk patients undergoing major non-cardiac surgery.
- Trial name
- PMI-VITAL (NCT05866874)
- Where
- Switzerland
- Volunteers
- 875 people
- Sponsor
- University Hospital, Basel, Switzerland
Myocardial Infarction Postoperative, Myocardial Injury
Intraoperative Hypotension and Perioperative Myocardial Injury
Acute myocardial infarction (MI) is a significant complication following non-cardiac surgery. We sought to evaluate incidence of perioperative MI, its preoperative - and intraoperative - risk factors and outcomes after this…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- NCT03974321
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Vascular Death, Myocardial Infarction
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)
The investigators' study has 4 primary objectives. Among patients undergoing noncardiac surgery the investigators will determine: (1) the incidence of major perioperative vascular events; (2) the optimal clinical model to predict…
- Conditions
- Vascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
- Trial name
- VISION (NCT00512109)
- Where
- 8 sites in Brazil, Canada and 5 more
- Volunteers
- 40,060 people
- Sponsor
- McMaster University
Perioperative Myocardial Infarction, Disability
Troponin Elevation After Major Noncardiac Surgery 2
Major adverse cardiac events (MACE) are a leading cause of mortality in patients undergoing noncardiac surgery. Patients with perioperative myocardial injury (PMI), defined as either myocardial infarction and lower elevations in…
- Conditions
- Perioperative Myocardial Infarction, Disability, Perioperative/Postoperative Complications
- Trial name
- TEAMS2 (NCT03408522)
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Coronary Heart Disease, Myocardial Injury
Intranasal Dexmedetomidine and Perioperative Myocardial Injury
PCI is the standard treatment for CAD, yet perioperative myocardial injury occurs frequently in nearly 40% of patients. Perioperative stress and sympathetic overactivation break myocardial oxygen balance and lead to cardiac…
- Conditions
- Coronary Heart Disease, Myocardial Injury, Myocardial Infarction, Dexmedetomidine
- Trial name
- NCT07549282
- Testing
- Intranasal Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myocardial Injury
Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery
This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period.
- Trial name
- POETRYminor (NCT02690233)
- Testing
- Elective Surgery
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Zealand University Hospital
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Cardiovascular Complications, Myocardial Infarction
Ankle-Brachial Index Estimating Cardiac Complications After Surgery
Introduction: Patients undergoing noncardiac surgery are at increased risk of cardiovascular complications. The development of methods that can accurately predict the occurrence of these events is of critical importance and large…
- Conditions
- Cardiovascular Complications, Myocardial Infarction, Acute Coronary Syndromes
- Trial name
- ABRACOS (NCT01452282)
- Where
- Brazil
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiac Valve Disease
Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
The aim of the study is to clarify whether the perioperative release of the cardiac biomarkers troponin I, troponin T and CK-MB consistently correlate with visualizable myocardial damage, and to what extent these biomarkers are…
- Trial name
- RORSCHACH (NCT06066970)
- Where
- 5 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Myocardial Injury After Noncardiac Surgery (MINS), Myocardial Ischemia
Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)
This study is a multicentre, randomized controlled trial of ivabradine versus placebo.
- Trial name
- PREVENT-MINS (NCT05279651)
- Testing
- Ivabradine
- Where
- 26 sites in Poland
- Volunteers
- 2,146 people
- Sponsor
- Jagiellonian University
Myocardial Injury, Myocardial Infarction
Implementation of a Clinical Screening and Response System for Cardiac Complications After Noncardiac Surgery
The investigators aim to show the feasibility and medicoeconomic impact of implementing a clinical screening and response system for the early detection of perioperative cardiac complications in high-risk patients.
- Conditions
- Myocardial Injury, Myocardial Infarction, Perioperative Complication
- Trial name
- ImplementPMI (NCT05859620)
- Testing
- Patient assessment and follow-up
- Where
- 5 sites in Austria, Switzerland
- Volunteers
- 900 people
- Sponsor
- University Hospital, Basel, Switzerland
Myocardial Infarction, Cardiac Arrest
Troponin-T for Detection of Perioperative Cardiovascular Events
We will conduct a prospective cohort study evaluating the incidence of and optimal risk estimation model for major perioperative cardiovascular events in consecutive patients undergoing noncardiac surgery at the 'Herlev…
- Trial name
- VISION-pilot (NCT00443989)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction Postoperative, Myocardial Injury
Myocardial Infarction in the Perioperative Setting
Acute myocardial infarction (AMI) is a significant complication following non-cardiac surgery. The investigators sought to evaluate incidence of perioperative AMI, its preoperative and intraoperative risk factors and the outcomes…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- MIPS (NCT03837535)
- Testing
- Surgery
- Where
- Sweden
- Volunteers
- 400,742 people
- Sponsor
- Karolinska University Hospital
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Steroids In caRdiac Surgery Trial (SIRS Trial)
SIRS trial is a large simple study in which high-risk patients undergoing cardiac surgery requiring the use of cardiopulmonary bypass (CPB) are randomly allocated to receive a pulse dose of Methylprednisolone or a matching…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome
- Trial name
- NCT00427388
- Testing
- Methylprednisolone
- Where
- Canada
- Volunteers
- 7,507 people
- Sponsor
- Population Health Research Institute
Myocardial Infarction, Surgery-Complications
Cardiology Consultation in Noncardiac Surgery
Recently, a predictive model has been developed to assess the risk of myocardial infarction or cardiac arrest (MICA) during and after surgery using the American Society of Surgeons' National Surgical Quality Improvement Program…
- Trial name
- NCT05532917
- Testing
- Gupta score
- Where
- Turkey (Türkiye)
- Volunteers
- 898 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Cardiovascular Diseases, Heart Diseases
Predictors of Perioperative Cardiac Morbidity
To determine the predictors of perioperative cardiac morbidity and mortality in patients at high risk who underwent major noncardiac surgery with general anesthesia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT00005197
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)