Clinical trials: Perioperative Neurocognitive Disorder
Postoperative Delirium
Predicting Postoperative Delirium Using EEG, Genetics and Neurobiomarkers of Cerebral Injury
The overall goal of this research project is to elucidate underlying pathophysiological mechanisms of postoperative delirium (POD) and to specifically validate perioperative predictive factors that will help in indentifying…
- Trial name
- POD-01 (NCT03706989)
- Testing
- EEG, Apolipoprotein genotype, Serum NfL measurements
- Where
- Belgium
- Volunteers
- 387 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Orthopedic Surgery
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients
Postoperative delirium (POD) is one of the most frequent complications after surgery in elderly patients, affecting between 20 and 40% of patients older than 60 after major surgery.
- Trial name
- DELIRLESS (NCT04335968)
- Testing
- Melatonin 4 mg
- Where
- France
- Volunteers
- 357 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Surgery, Perioperative Neurocognitive Disorders
Exploring the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders Following Cardiovascular Surgery
To explore the predictive value of Electroencephalography features in Perioperative Neurocognitive Disorders in patients undergoing cardiovascular surgery under general anesthesia
- Trial name
- NCT06692309
- Testing
- cardiovascular surgery
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Perioperative Neurocognitive Disorder
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear.
- Trial name
- NCT06488807
- Testing
- Olfactory Enrichment
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Shanghai 10th People's Hospital
Cognitive Dysfunction
The Influence of Ventilation on Perioperative Neurocognitive Disorders
This prospective study is designed to examine the influence of intra-operative ventilation on perioperative neurocognitive disorders in patients undergoing total hip arthroplasty.
- Trial name
- NCT04106869
- Testing
- Hyperventilation, Hypoventilation
- Where
- Belgium
- Sponsor
- Université Libre de Bruxelles
Perioperative Complications
Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients
To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction
- Trial name
- POCD (NCT02387541)
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Perioperative Complication, Infections
Perioperative Longitudinal Study of Complications and Long-term Outcomes
Purpose: with an increased risk of complications. Improved preoperative risk stratification and earlier diagnosis of these complications may ameliorate postoperative recovery and improve long-term outcomes.
- Conditions
- Perioperative Complication, Infections, Myocardium; Injury, Kidney Injury
- Trial name
- PLUTO (NCT05331118)
- Where
- Netherlands
- Volunteers
- 9,000 people
- Sponsor
- UMC Utrecht
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Aortic Diseases, Cardiac Surgical Procedures
Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic Surgery
In ascending aortic surgery the distal anastomosis may be constructed with the aortic cross-clamp maintained, or, where the extent of the aortic pathology and the geometry of the graft require it, after release of the cross-clamp…
- Conditions
- Aortic Diseases, Cardiac Surgical Procedures, Aortic Aneurysm, Thoracic, Delirium - Postoperative
- Trial name
- SACP-ONSD (NCT07800806)
- Testing
- Optic nerve sheath and optic nerve diameter ultrasonography, Transcranial Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Delirium, Postoperative Cognitive Dysfunction
Biomarkers Associated With Postoperative Cognitive Dysfunction
Loss of cognitive function after major surgery is a significant risk in older people. It can occur acutely in the days after surgery as delirium or in months to years later as a persistent reduction in brain function termed…
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- NCT05464355
- Testing
- Intraoperative electroencephalography recording, Neurofilament light chain measurement, Tau protein measurement
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Oxford
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cognitive Function Abnormal, Anesthesia
Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function
Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently from systemic blood pressure fluctuations.
- Conditions
- Cognitive Function Abnormal, Anesthesia, Surgery
- Trial name
- NCT04101006
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Perioperative Neurocognitive Disorders
Association Between Iron Reserves and Perioperative Neurocognitive Disorders
Iron metabolism disorder have been identified as the pivotal contributor in the pathogenesis and progression of perioperative neurocognitive disorders.
- Trial name
- NCT06502912
- Testing
- no intervention
- Volunteers
- 12,984 people
- Sponsor
- Chinese PLA General Hospital
Cognitive Dysfunction, Cardiac Morbidity
The Difference in Postoperative Cognitive Dysfunction and Myocardial Ischemia Between Propofol and Isoflurane
The progressive aging of the general population cause increase in number of extensive and long surgeries in older patients. Age is a risk factor for perioperative myocardial ischemia and Postoperative Cognitive Dysfunction (POCD)…
- Trial name
- POCD (NCT00908518)
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute
Perioperative Neurocognitive Disorders, Postoperative Quality of Recovery
Cognitive Function and Postoperative Quality of Recovery
This study aims to assess the association between perioperative cognitive function and postoperative quality of recovery.
- Trial name
- KoSQoR (NCT06905366)
- Volunteers
- 140 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cognitive Dysfunction, Burns
PRIME: Cognitive Outcome Following Major Burns
PRIME aims to demonstrate through neurocognitive assessment that BICU patients will have a degree of neurocognitive dysfunction following a major burn, that this neurocognitive dysfunction is due to an underlying…
- Conditions
- Cognitive Dysfunction, Burns, Inflammation, Brain, Quality of Life
- Trial name
- PRIME (NCT03242395)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Behavior Problem
Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children
The goal of this clinical trial is to learn whether intranasal dexmedetomidine or esketamine given before anesthesia can reduce negative postoperative behavioral changes in children undergoing day surgery.
- Trial name
- PEDI-NPOBCs (NCT07570160)
- Testing
- Dexmedetomidine, Esketamine, Normal Saline
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Nanjing Children's Hospital