Clinical trials: Perioperative Pain, open to volunteers
Complex Obstetric Surgery, Perioperative Pain Management
COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block
To assess the effect of intraoperative transversus abdominis plane (TAP) blocks on the amount of opioid pain medications expressed as morphine milliequivalents (MME) used postoperatively in patients who have undergone cesarean…
- Conditions
- Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
- Trial name
- COMFORT (NCT06925152)
- Testing
- Bupivicaine intervention arm
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Tennessee
Perioperative Pain in Robotic Prostatectomy
Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy
Tramadol and magnesium have already been researched in recent decades for their different roles in pain control. This clinical study will compare and re-evaluate their effect on the duration and quality of analgesia provided by a…
- Trial name
- NCT07289321
- Testing
- Ultrasound - guided bilateral transversus abdominis plane block (TAP) in patients undergoing robotic-assisted radical prostatectomy.
- Where
- Greece
- Volunteers
- 105 people
- Sponsor
- Aretaieion University Hospital
Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty
Perioperative Colchicine for TKA
This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty, Perioperative Pain Control
- Trial name
- NCT06936709
- Testing
- Colchicine 1.8 mg + 0.6 mg
- Volunteers
- 75 people
- Sponsor
- Geisinger Clinic
Perioperative Care, Pediatric Anesthesia
Giving Children a Voice in Paediatric Anaesthesia
This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the…
- Conditions
- Perioperative Care, Pediatric Anesthesia, Pain Management, Anxiety
- Trial name
- TR-VP26 (NCT07524049)
- Where
- 7 sites in Switzerland
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Postsurgical Pain, Chronic Opioid Users
Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:
Chronic opioid users undergoing surgery are at increased risk of CPSP, contributing to long-term disability, decreased quality of life, and prolonged opioid exposure.
- Conditions
- Chronic Postsurgical Pain, Chronic Opioid Users, Transitional Pain Service, Postoperative Pain
- Trial name
- PRE-OPIOID (NCT07717151)
- Testing
- standard institutional perioperative management, specialized teleconsultation
- Where
- France
- Volunteers
- 354 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Perioperative Pain Management, Gastreoesophageal Reflux Disease
Intrathecal Analgesia in Laparoscopic Nissen Fundoplication.
Patients planned for laparoscopic Nissen fundoplication or robotic- assisted laparoscopic surgery will receive either intrathecal morphine, intrathecal fentanyl or iv morphine (control).
- Trial name
- NCT07629323
- Testing
- Fentanyl Intrathecal 20ug, NOL-guided intravenous morphine analgesia, Intrathecal Morphine 100ug
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Karlstad Central Hospital
Cleft Palate, Pain
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.
- Conditions
- Cleft Palate, Pain, Postoperative Care, Perioperative Care
- Trial name
- OPAL-Cleft (NCT06962306)
- Testing
- Methadone hydrochloride, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Pain Management, Perioperative Analgesia
From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma
To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.
- Conditions
- Pain Management, Perioperative Analgesia, War-Related Injuries
- Trial name
- CRA-WAR-LIMB S (NCT07474506)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Perioperative Analgesia, Hip Replacement, Total
Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty
The Pericapsular Nerve Group (PENG) block is an effective method for postoperative pain management in patients undergoing primary total hip arthroplasty (THA) via a posterolateral approach.
- Conditions
- Perioperative Analgesia, Hip Replacement, Total, Postoperative Pain, Hip Disease
- Trial name
- NCT07449585
- Testing
- PNEG block, Spinal anesthesia with opioid, Spinal anesthesia without opioid
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
Pain, Postoperative, Opioid Use
Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain
The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management…
- Conditions
- Pain, Postoperative, Opioid Use, Perioperative Complication, Heart Diseases
- Trial name
- NCT06077422
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Rutgers, The State University of New Jersey
Pain, Perioperative
Reducing Pain From Retinal Laser With Vibrational Stimulation
The goal of this clinical trial is to learn if Vibration Anesthesia Device works to reduce pain during retinal laser for diabetic retinopathy.
- Trial name
- NCT06649604
- Testing
- Vibration Anesthesia Device, Panretinal Photocoagulation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Enhanced Recovery, Functional Endoscopic Sinus Surgery
Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries
Enhanced recovery after ear, nose and throat surgery is based on multimodal and multidisciplinary perioperative interventions to decrease postoperative pain.
- Conditions
- Enhanced Recovery, Functional Endoscopic Sinus Surgery, Lidocaine, Magnesium Sulphate
- Trial name
- NCT06966102
- Testing
- Lidocaine group, Magnesium group, Control group
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Cairo University
Pain, Anesthesia
Impact of Intraoperative Non-invasive Analgesia Monitoring Using Nociception Level Index on Patient Management
This prospective randomised clinical trial aims to assess the impact of intraoperative nociception monitoring using NOL on anesthetic management during major abdominal surgery.
- Conditions
- Pain, Anesthesia, Perioperative Care
- Trial name
- NCT06804434
- Testing
- Lidocaine Intravenous Infusion, NOL
- Where
- Romania
- Volunteers
- 160 people
- Sponsor
- Osoian Cristiana
ERAS, Gynecologic Cancer
Enhanced Recovery Protocols in Gynecologic Oncology
Enhanced Recovery After Surgery (ERAS) are developed to provide a systematic structure for managing postsurgical patients.These protocols promote evidenced-based practices and implement a multidisciplinary effort to maintain…
- Conditions
- ERAS, Gynecologic Cancer, Perioperative Complication, Postoperative Pain
- Trial name
- ERGO (NCT06655506)
- Testing
- ERAS group, Control group
- Where
- 8 sites in Greece
- Volunteers
- 600 people
- Sponsor
- National and Kapodistrian University of Athens