Clinical trials: Periorbital
Lower Eyelid Steatoblepharon (Excess Eyelid Fat)
Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)
This study will test whether XAF5 (XOPH5) ointment, applied once daily to the lower eyelids for 10 weeks, reduces the prominence of lower eyelid fat in adults with moderate to severe steatoblepharon (excess eyelid fat).
- Trial name
- NCT02230761
- Testing
- XOPH5 Ointment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Topokine Therapeutics, Inc.
Periorbital Hyperpigmentation
Physiopathologic Aspects and Quality of Life in Participants With Eye Dark Circles
This study will evaluate the physiopathologic characteristics of dark circles in participants with various ethnicities and Fitzpatrick Skin Types and the impact of the dark circles on the quality of life.
- Trial name
- NCT03400202
- Testing
- Skin imaging, Facial cleanser
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Allergan
Dry Eye
Effect of Periorbital Massage on Dry Eye Disease
This randomized controlled trial aims to investigate the efficacy of periorbital massage therapy in alleviating symptoms and improving clinical outcomes in patients diagnosed with dry eye disease.
- Trial name
- NCT06390644
- Testing
- Periorbital Massage Therapy, Control Group (Standard Care)
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Superior University
TNF-receptor Associated Periodic Syndromes (TRAPS)
Efficacy and Safety Study of ACZ885 in Patients With Active Recurrent or Chronic TNF-receptor Associated Periodic Syndrome (TRAPS).
This trial will assess the safety and efficacy of ACZ885 in patients with active recurrent or chronic TNF-receptor associated periodic syndrome (TRAPS).
- Trial name
- NCT01242813
- Testing
- ACZ885
- Where
- 6 sites in Ireland, Italy and 1 more
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Skin Health
A Clinical Trial to Evaluate the Effects of a Skin Balm on the Appearance of the Eye Area
This virtual single-group clinical trial aims to evaluate the effects of the Sahajan Golden Glow Balm on the health and appearance of the skin in the periorbital area over a period of 6 weeks.
- Trial name
- NCT06452810
- Testing
- Experimental: Sahajan Golden Glow Balm
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sahajan
Peri-orbital Wrinkles, Peri-oral Wrinkles
Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser
The Diode laser system is being used in this marketing study for the treatment of wrinkles around the eyes and mouth.
- Trial name
- NCT01813760
- Testing
- Illuiminage ® Diode Laser
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cynosure, Inc.
Other Degenerative Disorders of Eyelid and Periocular Area
Botulinum Toxin to Improve Lower Blepharoplasty Scar
The combination of Botulinum toxin for crow feet (lateral part of orbicularis oculi muscle) and lower blaphaloplasty might have reduces the tension on the end of lower blaphaloplasty incision whereas the scar is more visible on…
- Trial name
- NCT02786550
- Testing
- Botulinum Toxin, Normal Saline
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Nausea, Vomiting
Periorbital Massage for Nausea and Vomiting After Laparoscopic Surgery
Laparoscopic cholecystectomy is one of the commonly used surgical treatment methods for gallbladder diseases. However, many patients experience significant nausea and vomiting after laparoscopic cholecystectomy.
- Conditions
- Nausea, Vomiting, Laparoscopic Cholecystectomy
- Trial name
- NCT06954935
- Testing
- periorbital massage
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Atlas University
Melasma, Rosacea
Microfocused Ultrasound for Facial Pigmentary Diseases and Rosacea
This clinical study will evaluate the efficacy and safety of microfocused ultrasound treatment in patients with facial pigmentary diseases and rosacea.
- Conditions
- Melasma, Rosacea, Periorbital Hyperpigmentation, Melanosis
- Trial name
- NCT07667972
- Testing
- Microfocused Ultrasound Treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Dry Eye Disease
Study of Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Who Are Scheduled for Laser Epithelial Keratomileusis (LASEK) Surgery
This study aims to evaluate the efficacy and safety of applying pulse Electrical Stimulation around eye after laser keratoplasty (LASEK) in patients with dry eye syndrome.
- Trial name
- NCT06120348
- Testing
- Charge-Balanced, Symmetric Nerve Stimulation
- Where
- 6 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- Nu Eyne Co., Ltd.
Indication for CSF Dynamic Testing, Indication for CSF Infusion Test
Investigation of a New Window Into Intracranial Pressure: Venous Occlusion Pressure of the Isolated Periorbital Vein
Elevated intracranial pressure (ICP) occurs when pressure inside the skull rises above normal levels, potentially leading to brain damage or herniation.
- Trial name
- VOPxICP (NCT07053631)
- Testing
- venous occlusion pressure Measurement
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Freiburg
Periorbital Wrinkles
Evaluation of the Effectiveness and Safety of the Ulthera™ System for the Treatment of Wrinkles Around the Eyes
The purpose of this study is to look at how safe and effective the Ulthera ultrasound system is at reducing the appearance of wrinkles when used with subjects who have wrinkles around the eyes.
- Trial name
- NCT00747422
- Testing
- Ulthera™ System
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ulthera, Inc
Facial Aging, Skin Rejuvenation
Performance and Safety of Semical Dermal Fillers in Facial Rejuvenation
The aim of the study is to verify safety and performance of Semical dermal fillers according to real-world data.
- Conditions
- Facial Aging, Skin Rejuvenation, Volume Defects in the Mid-face, Lip Augmentation and Correction of Perioral Rhytids
- Trial name
- SEMDERMA (NCT07160777)
- Testing
- cross-linked hyaluronic acid, Mesolifter
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semikal Technology
Periorbital Edema
Energy-Based Lower Eyelid Rejuvenation - Proof of Concept for InMode AccuTite With or Without Morpheus8
1. To establish clinical efficacy, safety and patient satisfaction of reducing lower eyelid convexities or "bags" and/or malar crescents (festoons) with catheter-based injectable RF (InMode AccuTite) and variable depth Fractional…
- Trial name
- NCT04103619
- Testing
- AccuTite, AccuTite + Morpheus 8
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- InMode MD Ltd.
Facial Skin, Motion Capture
Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations
The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region.
- Conditions
- Facial Skin, Motion Capture, Aging, Periorbital Region
- Trial name
- REGARD (NCT07080320)
- Testing
- MoCap
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Glabellar Lines, Midface Volume Deficiency
Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure
The goal of this observation is to assess the time course of holistic extended periorbital rejuvenation using botulinum toxin A, cross-linked hyaluronic acid and polynucleotides corresponding to the application in routine…
- Conditions
- Glabellar Lines, Midface Volume Deficiency, Periorbital Wrinkling
- Trial name
- NCT07398755
- Testing
- Letybo®, Philart® Eye, Saypha® Volume Plus Lidocaine
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yuvell
Skin Wrinkles
Study on the Safety, Efficacy of Home RF Cosmetic Instrument in the Treatment of Facial or Periorbital Wrinkles
This is a multicenter trial with randomized control and evaluator blind method, which meets the screening criteria total of 224 subjects were enrolled and randomly divided into control group and experiment according to 1:1 ratio…
- Trial name
- YM-1 (NCT06441799)
- Testing
- Home radiofrequency skin treatment instrument, Ultrasonic coupler for medical purposes
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Glomed(HN)Co.Ltd
Periorbital Hyperpigmentation (Dark Circles)
A Study to Determine the Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Treatment of Dark Circles
This is a multicentre, open label, randomized, pilot study to evalute safety and efficacy of Human Platelet Lysate (HPL) in subjects with Periorbital Hyperpigmentation.
- Trial name
- NCT01644448
- Testing
- Autologous Human Platelet Lysate, Standard Therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Kasiak Research Pvt. Ltd.
Wrinkle
Confirmatory Study: Assessing the Efficacy and Safety of the AcusMu Microneedle Patch in Treating Periorbital Wrinkles
The core objective of this study is to validate the safe and efficacious application of the AcusMu microneedle patch (FMD WK) to enhance the appearance of periorbital wrinkle
- Trial name
- NCT06158867
- Testing
- FMD WK
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AcusMu Medtech Co., Ltd.
Orbital Fractures, Enophthalmos
Correction of Enophthalmos and Orbital Volume Using Pre-bent Mesh Versus 3d Printed Onlay in Orbital Fracture Cases
this study evaluates the post-surgical correction of enophthalmos and orbital volume using 3D printed only versus pre-bent titanium mesh in blow-out fracture cases
- Conditions
- Orbital Fractures, Enophthalmos, Periorbital Fracture
- Trial name
- NCT04271137
- Testing
- 3D printed PEEK onlay, Pre-bent orbital mesh
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University