Facial SkinREGARDNCT07080320
Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations
A study testing MoCap in people with Facial Skin and Motion Capture, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Facial Skin, Motion Capture, Aging
- What is being tested?
- MoCap
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 20 Sep 2025to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Female participants
- Caucasian, Fitzpatrick skin types I-III
- BMI between 18.5 and 27, healthy participants
- Aged 18 to 65 years (inclusive)
- Not under guardianship or curatorship
- Informed written consent
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- Social security affiliation
- Non-smokers for at least 5 years
- No excessive UV exposure (artificial or natural) in the last 3 weeks prior to the study or during the study
Who cannot join
- Severe skin disorders preventing the application of electrodes or photo-reflective markers
- Neurovascular history affecting the face
- Ongoing treatments influencing facial tissues (e.g., corticosteroids)
- Current sleep disorders
- Psychiatric conditions or social interaction impairments
- Inner ear or balance disorders
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- Osteoporosis, recent fractures, or fragile bone conditions
- Pregnant or breastfeeding women
- Under guardianship, curatorship, or legal protection
Trial locations and contacts
1 site in 1 country.
About this study
The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. This study will validate MoCap as a tool for quantifying these properties, comparing it to traditional reference tools, and exploring how these properties evolve with age and external treatments. It will also assess MoCap's ability to detect the effects of various treatments such as tightening products and massages. Ultimately, this research will provide a deeper understanding of skin dynamics in the periorbital region and offer insights into both medical and cosmetic applications.
- Conditions
- Facial Skin, Motion Capture, Aging, Periorbital Region, Skin Movement, Vertical Jump
- Being tested
- MoCap
- Keywords
- Facial skin, motion capture, aging, periorbital region, mechanical, skin movement, vertical jump
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MoCapDevice
For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used.
The intervention will be Interventions :
- Recruitment of healthy and pathological subjects.
- Full-face and macro images of the periorbital region
- Measurement of periorbital skin properties using MoCap and standard reference tools.
- Application of a tightening product (aloe vera) and periorbital massage.
- Measurement of skin response to a vertical jump.
| Study group | Role | What they receive |
|---|---|---|
| subjects aged 18-33 years | Experimental | Not described Receives: Device: MoCap |
| subjects aged 50-65 years | Experimental | Not described Receives: Device: MoCap |
What is being measured
The primary outcome is the main question the study is designed to answer.
maximum displacement (in millimeters) of each marker placed on the face
maximum displacement (in millimeters) of each marker placed on the face during standardized movements of the periorbital region
Measured: day 1
Secondary outcomes (6)
Coefficient of variation of the maximum displacement amplitudes measured during repeated tests for the same movement.
Measured: day 1
The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.
The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.
Measured: day 1
The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups
The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups
Measured: day 1
The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage
The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage
Measured: day 1
The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).
The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).
Measured: day 1
The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).
The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).
Measured: day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jul 2025
- Study start20 Sep 2025
- Primary completionAug 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Facial SkinStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07080320
- Sponsor's protocol ID
- PI2025_843_0101
- Acronym
- REGARD
- Status last verified
- Feb 2026
- First submitted
- 15 Jul 2025
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations
- ClinicalTrials.gov ID
- NCT07080320
- Acronym / sponsor ID
- REGARD / PI2025_843_0101
- Conditions
- Facial Skin, Motion Capture, Aging, Periorbital Region, Skin Movement, Vertical Jump
- Keywords
- Facial skin, motion capture, aging, periorbital region, mechanical, skin movement, vertical jump
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Study start
- 20 Sep 2025 (actual)
- Primary completion
- Aug 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 23 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. This study will validate MoCap as a tool for quantifying these properties, comparing it to traditional reference tools, and exploring how these properties evolve with age and external treatments. It will also assess MoCap's ability to detect the effects of various treatments such as tightening products and massages. Ultimately, this research will provide a deeper understanding of skin dynamics in the periorbital region and offer insights into both medical and cosmetic applications.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| subjects aged 18-33 years | Experimental | Device: MoCap |
| subjects aged 50-65 years | Experimental | Device: MoCap |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- Female participants
- Caucasian, Fitzpatrick skin types I-III
- BMI between 18.5 and 27, healthy participants
- Aged 18 to 65 years (inclusive)
- Not under guardianship or curatorship
Key exclusion criteria (9 listed)
- Severe skin disorders preventing the application of electrodes or photo-reflective markers
- Neurovascular history affecting the face
- Ongoing treatments influencing facial tissues (e.g., corticosteroids)
- Current sleep disorders
- Psychiatric conditions or social interaction impairments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MoCapFor each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used. The intervention will be Interventions : * Recruitment of healthy and pathological subjects. * Full-face and macro images of the periorbital region * Measurement of periorbital skin properties using MoCap and standard reference tools. * Application of a tightening product (aloe vera) and periorbital massage. * Measurement of skin response to a vertical jump. | Device | subjects aged 18-33 years, subjects aged 50-65 years |
Primary outcome
maximum displacement (in millimeters) of each marker placed on the face
Time frame: day 1
maximum displacement (in millimeters) of each marker placed on the face during standardized movements of the periorbital region
6 secondary outcomes
Coefficient of variation of the maximum displacement amplitudes measured during repeated tests for the same movement.
Time frame: day 1
The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.
Time frame: day 1
The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups
Time frame: day 1
The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage
Time frame: day 1
The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).
Time frame: day 1
The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).
Time frame: day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MoCap in people with Facial Skin and Motion Capture, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
maximum displacement (in millimeters) of each marker placed on the face (time frame: day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.