Clinical trials: Peripartum Cardiomyopathy
Obesity, Pregnancy Complications
NT-proBNP Levels and Obesity in Pregnancy
A screening modality to help categorize obese pregnant women as high or low probability for heart failure would be helpful in the evaluation of the obese pregnant women with dyspnea.
- Conditions
- Obesity, Pregnancy Complications, Peripartum Cardiomyopathy
- Trial name
- NCT04049136
- Testing
- NT-proBNP
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Duke University
Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM)
Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Non-ischemic cardiomyopathies (NICM) represent a heterogeneous group of pathologies characterized by absence of obstructive disease of the epicardial coronary vessels and distinct structural and functional changes of the…
- Conditions
- Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive Cardiomyopathy
- Trial name
- AINICM (NCT06607471)
- Testing
- Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment
- Where
- Italy
- Volunteers
- 15,000 people
- Sponsor
- Scientific Institute San Raffaele
Cardiomyopathy, Pregnancy
Investigation in Pregnancy Associate Cardiomyopathy
Peri-partum cardiomyopathy is a heart muscle weakness that occurs during or following pregnancy. Research suggests that many initial heart injuries including viruses, pregnancy and other unknown causes, can lead to a process of…
- Trial name
- IPAC (NCT01085955)
- Where
- 30 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Peripartum Cardiomyopathy
Effect of Bromocriptine on Left Ventricular Function in Women With Peripartum Cardiomyopathy
This is a randomized, controlled clinical trial to evaluate the efficacy and safety of bromocriptine for improvement of left ventricular function of women with Peripartum cardiomyopathy (PPCM). A Multi center trial in Germany.
- Trial name
- PPCM (NCT00998556)
- Testing
- Bromocriptine
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Hannover Medical School
Peripartum Cardiomyopathy
Bromocriptine in the Treatment of Peripartum Cardiomyopathy
Peripartum cardiomyopathy (PPCM) is a rare, but significant heart disease affecting young women in the puerperal period. Thus far, no specific treatment has been approved to treat this disease.
- Trial name
- BRO-HF (NCT02590601)
- Testing
- Bromocriptine, Guideline-driven medical therapy (GDMT)
- Where
- Canada
- Sponsor
- Montreal Heart Institute
Peripartum Cardiomyopathy, Postpartum
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and…
- Trial name
- REBIRTH (NCT05180773)
- Testing
- Bromocriptine, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban
- Where
- 64 sites in United States
- Volunteers
- 250 people
- Sponsor
- Dennis M. McNamara, MD, MS
Peripartum Cardiomyopathy
A Registry of Peripartum Cardiomyopathy in Turkey
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality of young women. Its' etiology, epidemiology and treatment is not yet well described.
- Trial name
- NCT03364140
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ege University
Peripartum Cardiomyopathy
Creation of a Multicenter National Registry for Peripartum Cardiomyopathy.
Peripartum cardiomyopathy (PPCM) is a rare, severe and potentially life-threatening disorder of largely unknown etiology and pathophysiology, with unexplained geographical differences and heterogeneous presentation.
- Trial name
- PPCMREGISTRY (NCT05878041)
- Testing
- Molecular and genetic screening
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Cardiomyopathy, Pregnancy Related
Screening for Pregnancy Related Heart Failure in Nigeria
This study will evaluate the effectiveness of an artificial intelligence-enabled ECG (AI-ECG) for cardiomyopathy detection in an obstetric population in Nigeria.
- Trial name
- NCT05438576
- Testing
- Digital stethoscope electrocardiogram
- Where
- 6 sites in Nigeria
- Volunteers
- 1,232 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Peripartum Cardiomyopathy
Irisin Expression and Gene Polymorphism With Peripartum Cardiomyopathy.
this is an observertional study aimed at Study the association between the level of irisin expression and (Fibronectin Type III Domain Containing 5 (FDNC5) gene polymorphism in female patients with peripartum cardiomyopathy.
- Trial name
- NCT04927715
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cardiogenic Shock, Peripartum Cardiomyopathy
"Treatment Use of ECMO In Pregnancy or Peripartum Patient."
The goal of this study is to describe the use of ECMO (Extracorporeal Membrane Oxygenation) in the pregnant or peripartum patient.
- Conditions
- Cardiogenic Shock, Peripartum Cardiomyopathy, Complication, Pregnancy
- Trial name
- NCT04144660
- Testing
- Extracorporeal Membrane Oxygenation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sarah Thordsen
Ppm, Cardiomyopathy
Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy
This randomized, controlled clinical trial investigates the potential cardioprotective effects of melatonin in women diagnosed with peripartum cardiomyopathy (PPCM).
- Trial name
- MEL-PPCM (NCT07334197)
- Testing
- Melatonin 10 MG, Selenium
- Volunteers
- 25 people
- Sponsor
- Tanta University
Peripartum Cardiomyopathy, Cardiogenic Shock
PPCM Observational Study (Peripartum Cardiomyopathy)
The purpose of this study is to examine the clinical treatment of patients diagnosed with peripartum cardiomyopathy complicated by cardiogenic shock.
- Trial name
- NCT04234659
- Testing
- Clinical placement of a temporary IMPELLA® mechanical circulatory support device.
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical College of Wisconsin
Cardiomyopathy, Dilated
Clinical Observation of Long-term Cardiac Function Prognosis in Patients With PPCM Who Have Recovered Cardiac Function
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that occurs in late pregnancy and early postnatal period, which is mainly characterized by varying degrees of impaired ventricular systolic function and symptoms…
- Trial name
- NCT06039072
- Testing
- Patients with cardiac function recovered for more than one year and discontinued were in the discontinuation group.
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
Peripartum Cardiomyopathy
Taurine in Peripartum Cardiomyopathy
Taurine as an adjunct for early left ventricular recovery in peripartum cardiomyopathy
- Trial name
- NCT03907267
- Testing
- Taurine Solution, Normal Saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Peripartum Cardiomyopathy
Peripartum Cardiomyopathy in Nigeria Registry
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world.
- Trial name
- PEACE (NCT03081949)
- Testing
- Oral Sodium Selenite 200 µg/day for 3 months
- Where
- 2 sites in Nigeria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aminu Kano Teaching Hospital
Cardiomyopathy, Pregnancy-Associated Cardiomyopathy
Registry and Survey of Women With Pregnancy Related Cardiomyopathy
The goal of this study is to better characterize peripartum cardiomyoapthy or pregnancy-related cardiomyopathy by enrolling as many PPCM survivors as possible using both direct and web-based methods of recritment.
- Conditions
- Cardiomyopathy, Pregnancy-Associated Cardiomyopathy, Heart Failure
- Trial name
- NCT00273637
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- St. Vincent's Medical Center
Peripartum Cardiomyopathy, Diastolic Dysfunction
Diastolic Dysfunction PPCM in Patients With Documented Left Ventricular Systolic Function Recovery
The purpose of this project is to evaluate parameters of diastolic dysfunction assessed by clinical echocardiogram in patients who have had recovery of systolic function.
- Trial name
- NCT04143997
- Testing
- A clinical Transthoracic echocardiogram
- Where
- United States
- Sponsor
- Medical College of Wisconsin