Clinical trials: Peripheral Arterial Disease
Peripheral Arterial Disease
Ramipril Treatment of Claudication: Oxidative Damage and Muscle Fibrosis
Peripheral artery disease (PAD) is a manifestation of atherosclerosis that produces progressive narrowing and occlusion of the arteries supplying the lower extremities.
- Trial name
- NCT02842424
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Nebraska
Peripheral Artery Disease, Diabetes Mellitus
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical…
- Conditions
- Peripheral Artery Disease, Diabetes Mellitus, Chronic Limb-Threatening Ischemia
- Trial name
- NCT03622359
- Testing
- SPECT/CT perfusion imaging, PET/CT perfusion imaging
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Peripheral Arterial Disease, Chronic Kidney Diseases
Preventing Kidney Injury Using Carbon Dioxide as Contrast Medium in Patients With Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) Having Arterial Intervention
This research trial will test whether using carbon dioxide as a contrast medium during surgery to open blocked leg arteries can prevent kidney injury.
- Conditions
- Peripheral Arterial Disease, Chronic Kidney Diseases, Acute Kidney Injury
- Trial name
- KID (NCT07891988)
- Testing
- Iodinated contrast medium, CO2 automated injector contrast medium
- Where
- 6 sites in United Kingdom
- Volunteers
- 184 people
- Sponsor
- University of Leicester
Critical Limb Ischemia, Peripheral Arterial Disease
Foot Perfusion Analysis to Predict Limb Salvage
This study aims at evaluating the correlation between foot perfusion on angiographies performed before and after revascularization and limb salvage in patients with critical limb ischemia.
- Trial name
- DELTA-PERF (NCT03810469)
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier de Valenciennes
Peripheral Arterial Disease
Observational Study to Assess Transradial Access for Treatment in the Lower Extremities.
This study is designed to collect data on the complication rates and procedural success of using a transradial access approach to treat peripheral lesions in the lower extremities of a real world population.
- Trial name
- R2P Registry (NCT04371861)
- Testing
- Peripheral Artery Treatment
- Where
- 8 sites in United States
- Volunteers
- 120 people
- Sponsor
- Terumo Medical Corporation
Peripheral Arterial Disease
The Isthmus Logic Post Market Clinical Follow-up Study
Isthmus Logic Carbostent™ is a CE-marked cobalt chromium stent with a bio inducer surface for the treatment of peripheral iliac artery disease.
- Trial name
- NCT05616143
- Testing
- Isthmus Logic
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- CID S.p.A.
Peripheral Arterial Disease
The Cre8™ BTK Post Market Clinical Follow-up Study
Cre8™ BTK is a CE marked drug eluting stent, integrally coated with i-Carbofilm, loaded with formulated Sirolimus for the treatment of infrapopliteal peripheral artery disease.
- Trial name
- NCT05616156
- Testing
- Cre8™ BTK
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- CID S.p.A.
Peripheral Artery Disease, Peripheral Arterial Occlusive Disease
The EasyFlype/EasyHiFlype Post Market Clinical Follow-up Study.
The Easy Flype Carbostent™ is a CE-marked nitinol self-expanding stent for superficial femoral artery (SFA) and Easy HiFlype Carbostent™is a CE-marked nitinol self-expanding stent for iliac vessels.
- Trial name
- NCT05616169
- Testing
- Easy Flype/EasyHiFlype
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- CID S.p.A.
Peripheral Arterial Disease
The Inperia Advance Post-Market Retrospective Study
The Inperia Advance Carbostent™ is a CE-marked infra-popliteal stent for treatment of infra-popliteal artery stenosis. The aim of this post-market retrospective study protocl P32203 is to collect clinical data of patients treated…
- Trial name
- NCT05622084
- Testing
- Inperia Advance
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CID S.p.A.
Peripheral Artery Disease (PAD)
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease
This study is researching 2 different experimental drugs called REGN7508 and REGN9933. The study is focused on people who have Peripheral Artery Disease (PAD), which means that the blood vessels in their arms and legs have become…
- Trial name
- ROXI-PALISADE (NCT07318610)
- Testing
- REGN7508, REGN9933, Rivaroxaban
- Where
- 29 sites in United States, United Kingdom
- Volunteers
- 7,050 people
- Sponsor
- Regeneron Pharmaceuticals
Peripheral Artery Disease (PAD)
IV-X Medical Peripheral Intravascular Lithotripsy Study for PAD
To evaluate the safety and performance of the IV-X Medical Intravascular Lithotripsy (IVL) System in adults in order to demonstrate the ability of the IV-X Medical IVL System to safely and effectively deliver IVL treatment…
- Trial name
- HELIX-PAD (NCT07746362)
- Testing
- IV-X Medical IVL System
- Volunteers
- 140 people
- Sponsor
- IVX Medical
Peripheral Artery Disease
IV-X Medical First-in-Human Peripheral Intravascular Lithotripsy Study for PAD
To evaluate the safety and performance of the IV-X Medical Intravascular Lithotripsy (IVL) System in adults in order to demonstrate the ability of the IV-X Medical IVL System to safely and effectively deliver IVL treatment…
- Trial name
- HELIX-PAD-FIH (NCT07747883)
- Testing
- IV-X Medical IVL System
- Where
- Paraguay
- Volunteers
- 25 people
- Sponsor
- IVX Medical
Peripheral Artery Disease
Exercise Therapy for PAD Using Mobile Health
Peripheral artery disease (PAD) is a highly prevalent condition affecting up to 10% of Veterans that leads to loss of walking ability and increased risk of amputation.
- Trial name
- Smart MOVE (NCT04889105)
- Testing
- Smart MOVE!, General walking advice, Performance evaluation
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Peripheral Artery Disease
Telehealth to Improve Functional Status and Quality of Life in Veterans With PAD
The present study aims to increase Veteran access to supervised exercise therapy and expand its role in improving functional status, quality of life, and cardiovascular risk profile of Veterans with PAD.
- Trial name
- MOVE-IT (NCT05048979)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus, Peripheral Arterial Disease
Construction and Empirical Research of a Risk Prediction Model for Preventing Lower Extremity Arteriosclerosis Obliterans in Diabetic Patients Based on the HAPA Model
In this study, Logistic regression analysis was used to construct a risk prediction model for ASO in diabetic patients. Guided by the HAPA model, a nursing intervention plan for preventing ASO in diabetic patients was constructed…
- Trial name
- NCT07881588
- Testing
- Routine Care, Experimental group intervention
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Peripheral Arterial Disease
Exploring the Exercise Fear Experiences of Patients With Peripheral Arterial Disease: A Qualitative Study
This study explored the exercise fear experience of patients with lower extremity arteriosclerosis obliterans. We conducted qualitative interviews and identified four core themes contributing to patients' fear of physical…
- Trial name
- NCT07877129
- Testing
- a descriptive qualitative design
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Arteriovenous Malformation, Gastrointestinal Bleed
Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils
The purpose of the Case-Specific Health Care Professional (HCP) Clinical Survey for Concerto Versa™ Detachable Coils, also known as the Concerto Versa HCP Clinical Assessment, is to collect early clinical data from HCPs to assess…
- Conditions
- Arteriovenous Malformation, Gastrointestinal Bleed, Gastric Varices, Hemorrhoid
- Trial name
- NCT07639853
- Testing
- Concerto Versa™ Detachable Coils
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medtronic Endovascular
Chronic Limb Threatening Ischemia
Vessel Recoil in Specific CLTI Populations
Chronic limb threatening ischemia (CLTI) represents the most advanced stage of peripheral arterial disease (PAD) and is characterized by ischemic rest pain, non-healing wounds, or ischemic gangrene.
- Trial name
- NCT07465627
- Testing
- Vessel recoil measurement 15 minutes post final treatment (angiographically)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Peripheral Arterial Disease
A Study Evaluating the Endovascular Treatment of Subjects With Stenotic or Restenotic Lesions of the Common Femoral Artery With the Supera Vascular Mimetic Implant Compared to Surgical Common Femoral Artery Endarterectomy
The SUPERSURG RCT trial investigates the efficacy and safety of the endovascular treatment of stenosis or restenosis in the common femoral artery (CFA) of patients presenting with Rutherford classification 2,3 or 4 with a Supera…
- Trial name
- SUPERSURG-RCT (NCT04349657)
- Testing
- Supera Peripheral Stent System treatment group, Endarterectomy treatment group
- Where
- 13 sites in Belgium, Netherlands and 1 more
- Volunteers
- 286 people
- Sponsor
- KANDO Research
Peripheral Vascular Disease, Peripheral Arterial Disease
EVERO Drug-coated Balloon (DCB) Randomized Trial
The primary objective of the study is to evaluate the long-term safety and effectiveness of the Advance Evero™ 18 Everolimus-coated Percutaneous Transluminal Angioplasty Balloon Catheter (hereafter referred to as the Evero…
- Trial name
- NCT07144150
- Testing
- Evero DCB, Paclitaxel DCB
- Where
- 12 sites in United States
- Volunteers
- 410 people
- Sponsor
- Cook Research Incorporated