Clinical trials: Peripheral Arterial Diseases
Peripheral Vascular Diseases
Clinical Study on the Effectiveness and Safety Evaluation of Directional Atherectomy Combined With Drug-coated Balloons
DCB can maximize the patency rate of blood vessels on the basis of intraluminal DA. DA+DCB treatment is effective and safe [8], and the advantages of DA and DCB in the treatment of severe calcification and occlusive disease…
- Trial name
- Remove (NCT04986098)
- Testing
- TurboHawk, Paclitaxel
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Peripheral Arterial Disease
Investigating Efficacy and Safety of JETi® in Arterial Occlusions in FEM-POP and Prox BTK-Lesions (JETART)
To demonstrate the efficacy and safety of the mechanical thrombectomy device (JETi 6F and 8F) for treatment of patients with symptomatic peripheral artery disease (PAD) due to acute or acute on chronic occlusions of the femoral…
- Trial name
- JETART (NCT06434779)
- Testing
- JETi 6F and 8F Thrombectomy system
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vascular Science LP GmbH
Peripheral Artery Disease, Intermittent Claudication
Assessing Best Medical Treatment Patterns of Patients With Symptomatic Peripheral Arterial Occlusive Disease in Germany
This proposed study will be conducted to support real-world-evidence on the extent of best medical treatment for secondary prevention of patients with symptomatic peripheral arterial occlusive disease (PAOD) for prevention of…
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- NCT03909022
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Peripheral Artery Disease, Intermittent Claudication
VascTrac Peripheral Arterial Disease (PAD) Study
VascTrac is a mobile medical application that tracks users' physical activity levels in order to predict endovascular failure of patients with Peripheral Artery Disease.
- Trial name
- VascTrac (NCT03048890)
- Testing
- Physical activity levels
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Healthy, Hypercholesterolemia
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and therapeutic target for hypercholesterolemia and atherosclerotic cardiovascular disease (CVD).
- Conditions
- Healthy, Hypercholesterolemia, Hypertension, Overweight
- Trial name
- NCT06675994
- Testing
- PCSK9 Antibody, PCSK9 Enzyme
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
PAD
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via…
- Trial name
- EPR (NCT03900832)
- Testing
- Without Heating, Warm Bath, Neutral Bath
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Critical Limb Ischemia
A Safety and Tolerability Study of RJX Drug Product in Healthy Participants
Designed as a single center, two-part, double-blind, placebo-controlled, randomized study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of RJX in healthy participants.
- Trial name
- NCT03680105
- Testing
- RJX
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Reven Pharmaceuticals, Inc.
Peripheral Arterial Disease
Exoskeleton Footwear to Improve Walking
The purpose of this study is to determine the best assistance level of an exoskeleton footwear (EF) that can assist walking for people older than 40 with and without peripheral artery disease (PAD).
- Trial name
- NCT04337554
- Testing
- Exoskeleton footwear
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Angioplasty, Balloon, Disease, Peripheral Artery
Post-market Registry to Assess the Clinical Performance and Safety of the Passeo-18 Lux in Infrainguinal Arteries
The purpose of his study is to collect short term and long term clinical evaluation data of the Passeo-18 Lux Paclitaxel releasing balloon catheter, subject to patients who visit hospital from arteriosclerosis in the…
- Trial name
- NCT05175703
- Testing
- Passeo-18 Lux Paclitaxel releasing Balloon Catheter
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Peripheral Arterial Disease
Exoskeleton Variability Optimization
Exoskeletons, wearable devices that assist with walking, can improve mobility in clinical populations. With exoskeletons, it is crucial to optimize the assistance profile.
- Trial name
- NCT04338815
- Testing
- Exoskeleton Optimization, Endurance Evaluation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Arterial Disease (PAD)
Post-marketing Study in Femoral Popliteal Artery of Drug Coated Balloon Used for Treatment of Lower Limb Ischemia
The objective of this prospective, multi-center, single arm study is to obtain further data on the safety and performance of the Drug-coated Balloon catheters in the treatment of the Superficial Femoral Artery (SFA) and Popliteal…
- Trial name
- UltraFuture I (NCT05498740)
- Testing
- Drug eluting Balloon
- Where
- 24 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Peripheral Arterial Disease
Effects of Plant-Based Diet on Peripheral Arterial Disease
Cardiovascular disease (CVD), a condition predominantly caused by atherosclerosis, is the leading cause of morbidity and mortality in the investigator's society.
- Trial name
- NCT03798938
- Testing
- plant-based diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vascular Institute of Texas
Pulmonary Arterial Hypertension
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension
Pulmonary artery hypertension (PAH) is a rare, severe disease, characterized by a progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure and premature death.
- Trial name
- NCT01520493
- Testing
- Submaximal exercises
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Combined Anticoagulation and Antithrombotic Therapy, PAD - Peripheral Arterial Disease
Effectiveness of Combined Anticoagulation and Antithrombotic Therapy vs Antithrombotic Therapy Alone After Lower Extremity Revascularization for Peripheral Arterial Disease
EFFECTIVENESS OF COMBINED ANTICOAGULATION AND ANTITHROMBOTIC THERAPY VS ANTITHROMBOTIC THERAPY ALONE AFTER LOWER EXTREMITY REVASCULARIZATION FOR PERIPHERAL ARTERIAL DISEASE.
- Trial name
- NCT04994223
- Testing
- Rivaroxaban 10 MG Oral Tablet [Xarelto]
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi
Cardiovascular Risk Factor, Cardiovascular Diseases
VOPITB a New Devices to Determine Peripheral Arterial Stiffness: Validation Study
Our group has developed a device called "Velocidad Onda de Pulso Indice Tobillo Brazo (VOPITB)" . In this device the oscillometric method is used for easily and accurately measure the pulse wave velocity PWV in the arms and legs…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Atherosclerosis of Artery
- Trial name
- NCT04303546
- Testing
- arterial stiffness measurements
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Diabetes, Peripheral Arterial Occlusive Disease
Evaluate the Correlation of NIRS, ABI, Exercise, baPWV and Albuminuria With Peripheral Artery Occlusion Disease (PAD) and Other Atherosclerosis Outcomes
By utilizing Near infrared spectroscopy (NIRS), the local blood flow, tissue oxygenation (StO2), and recovery time of ischemic leg; can be determined.
- Trial name
- NCT03378024
- Testing
- oscillometric (Omron Colin co)
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Peripheral Vascular Disease, Intermittent Claudication
DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions
The objective of this clinical investigation is to evaluate the long-term (up to 12 months) outcome of the 200 mm long self-expanding nitinol EverFlex (ev3) stent in long femoropopliteal lesions (TASC C \& D) Is is the first time…
- Conditions
- Peripheral Vascular Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- NCT00637741
- Testing
- Everflex 200
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Flanders Medical Research Program
Acromegaly, Growth Hormone Deficiency
Peripheral Metabolic Effects of Somatostatin
The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled.
- Conditions
- Acromegaly, Growth Hormone Deficiency, Diabetes
- Trial name
- NCT01062529
- Testing
- Somatostatin
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Limb Threatening Ischemia
Multimodal Noninvasive Assessment of Peripheral Circulation in Chronic Limb-threatening Ischemia
Assessment of a novel diagnostic method for screening and diagnosing chronic limb-threatening ischemia (CLTI). Using hyperspectral and thermal imaging, the perfusion and oxygenation in the lower limbs will be studied in healthy…
- Trial name
- NCT05786001
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tampere University
Peripheral Arterial Disease
A Bioequivalence and Safety Study of AJU-B718 and B718R in Healthy Adult Volunteers Under Fasting Conditions
To evaluate the bioequivalence and safety of AJU-B718 and B718R in Healthy Adults.
- Trial name
- NCT07901088
- Testing
- Test Drug, Reference Drug
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AJU Pharm Co., Ltd.