Clinical trials: Peripheral Lung Lesions
Lung Cancer
Comparing Diagnostic Yield Between R-EBUS Guided Cryo Biopsy Vs. CT Guided Biopsy for PPL
Obtaining a tissue sample to diagnose a PPL suspected of cancerous origin is of utmost importance. The current gold standard; Transthoracic CT guided needle biopsy approach with a success rate of >90% comes at the expense of an…
- Trial name
- CT-CROP (NCT02395939)
- Testing
- CT guided core biopsy, Cryo-biopsy via Radial EBUS navigation
- Where
- New Zealand
- Volunteers
- 158 people
- Sponsor
- Middlemore Hospital, New Zealand
Lung Neoplasms
A Comparison Between EBUS-GS and CT-guided Lung Biopsy in Diagnosis of Peripheral Pulmonary Lesions.
This is a randomized controlled trail aiming at comparing the diagnostic value and safety of endobronchial ultrasonography with a guide sheath(EBUS-GS) and computed tomography-guided transthoracic needle biopsy(CT-TTNB) for…
- Trial name
- NCT02740400
- Testing
- EBUS-GS, CT-TTNB
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Lung Cancer, Nodes, Lung
Confirmation of Accuracy of the Tool-in-lesion Technology (TiLT) of the Galaxy System With Integrated TOMO Technology
This study will evaluate the feasibility of performing robotic navigation of peripheral airways in human subjects for the purpose of biopsying peripheral lung lesions.
- Trial name
- TiLT (NCT06056128)
- Testing
- Robotic assisted bronchoscopy
- Where
- Hong Kong
- Volunteers
- 25 people
- Sponsor
- Noah Medical
Lung Cancer
Prospective Cohort of Diagnostic Bronchoscopy for Peripheral Lung Lesions
The primary objective is To evaluate the usefulness and safety of advanced guided bronchoscopy for histological diagnosis of peripheral pulmonary lesions.
- Trial name
- NCT05804786
- Testing
- Guided bronchoscopy
- Where
- 11 sites in South Korea
- Volunteers
- 1,240 people
- Sponsor
- Seoul National University Bundang Hospital
Peripheral Pulmonary Lesions
Study on the Influence of Fluoroscopy in the Diagnosis of Peripheral Lung Lesions With Endobronchial Ultrasound Guidance
The purpose of this study is to determine whether the use of fluoroscopy improves the diagnostic yield of peripheral pulmonary lesions' biopsy guided by radial endobronchial ultrasound (with the use of a guide sheath).
- Trial name
- NCT01863836
- Testing
- Fluoroscopy, Radial EBUS-guided biopsy
- Where
- Canada
- Volunteers
- 133 people
- Sponsor
- Laval University
Lung; Node
Robotic Bronchoscopy for Peripheral Pulmonary Lesions
In this study, the feasibility of performing robotic navigation of peripheral airways in human subjects for the purpose of biopsying peripheral lung lesions will be evaluated.
- Trial name
- NCT03727425
- Testing
- Robotic assisted bronchoscopy
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Auris Health, Inc.
Lung Cancer
Conventional vs Ultrathin Bronchoscopy for Peripheral Pulmonary Lesions
This study's purpose is to evaluate whether the use of an ultra-thin bronchoscope can improve sensitivity and diagnostic yield in peripheral pulmonary nodules.
- Trial name
- NCT04029155
- Testing
- Lung biopsy
- Volunteers
- 142 people
- Sponsor
- Stefano Gasparini
Lung Cancer
VBN-EBUS-GS-TBLB With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the feasibility, efficacy and safety of transbronchial lung biopsy (TBLB) and bronchial brushing by using virtual bronchoscopic navigation (VBN) combined with endobronchial ultrasound…
- Trial name
- NCT02484066
- Testing
- VBN, EBUS-GS, X-ray
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Jiayuan Sun
Peripheral Pulmonary Lesions
EBUS-Guided TBNA Increases the Diagnostic Yield of Peripheral Pulmonary Lesions
The diagnosis of peripheral pulmonary lesions(PPLs) remained a clinical challenge for physicians. Bronchoscope with sampling procedures was recognized as a useful method to obtain the correct diagnosis of PPLs.
- Trial name
- NCT00626587
- Testing
- Olympus NA-2C-1 Transbronchial needle aspiration (TBNA)
- Where
- Taiwan
- Volunteers
- 182 people
- Sponsor
- Chang Gung Memorial Hospital
Lung Cancer
Transbronchial Catheter Aspiration and Transbronchial Needle Aspiration in the Diagnosis of Lung Cancer
The aim of this study is prospectively to determine the diagnostic sensitivity of Transbronchial Catheter Aspiration (TBCA) in comparison with Transbronchial Needle Aspiration (TBNA) in the diagnosis of peripheral nodules and…
- Trial name
- NCT00807391
- Testing
- TBCA, TBNA
- Where
- 2 sites in Germany
- Volunteers
- 48 people
- Sponsor
- Helios Klinik Ambrock
Peripheral Lung Lesions
Electromagnetic Navigation for Peripheral Pulmonary Lesions
Despite technological advancements directed towards the diagnosis of peripheral pulmonary lesions, an optimal approach has yet to be designed.
- Trial name
- NCT02582944
- Testing
- Olympus BF-180 bronchoscope (standard adult), Veran Spinview Thoracic Navigation System, Olympus UM-S20-17S
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington University School of Medicine
Lung Cancer
CT-controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Augmented Fluoroscopy Bronchoscopic Navigation Based Diagnostic Yield
In this exploratory adaptive clinical trial the investigators will examine the diagnostic yield of a combination of commercially available imaging and navigation techniques for reaching peripheral lung lesions.
- Trial name
- CONTROL-A (NCT03274609)
- Testing
- Augmented fluoroscopy
- Where
- Netherlands
- Volunteers
- 47 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
Utility of Endobronchial Ultrasound in the Investigation of Suspected Lung Cancer.
Bronchoscopy of non visible lesions in the lung, have a low diagnostic yield. The use of endoscopic ultrasound might increase the diagnostic yield.
- Trial name
- NCT00398970
- Testing
- Endobronchial ultrasound miniprobe
- Where
- Norway
- Volunteers
- 240 people
- Sponsor
- Haukeland University Hospital
Lung; Node
Robotic Systems Evaluation for Peripheral Pulmonary Lesions (RISE Trial)
This is an investigator-initiated cluster randomized control trial. The primary objective is to compare the diagnostic yield of two Food and Drug Administration (FDA) cleared national robotic assisted bronchoscopy platforms - the…
- Trial name
- NCT07735611
- Testing
- RAB via the Monarch platform, RAB via the ION platform
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- Case Comprehensive Cancer Center
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Lung Cancer
UTB-VBN-EBUS With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the feasibility,efficacy and safety of ultrathin bronchoscopy(UTB) combined with virtual bronchoscopic navigation(VBN) and endobronchial ultrasound(EBUS) for the diagnosis of peripheral…
- Trial name
- NCT02664259
- Testing
- VBN, EBUS, X-ray
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Secondary Lung Cancer
Conventional Bronchoscopy Plus Rose Versus Electromagnetic Navigation (EMN) Plus Rose in Small Peripheral Lesions
The aim of this study is to evaluate if Electromagnetic navigation (ENB) in combination with rapid on site evaluation (ROSE) can improve diagnostic accuracy in those patients who fail to be diagnosed with conventional…
- Conditions
- Lung Cancer, Secondary Lung Cancer, Benign Lung Lesions
- Trial name
- NCT00880945
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Lung Neoplasm
Exploration of Optical Coherence Tomography-Guided Transbronchial Biopsy in Peripheral Pulmonary Lesions
In this prospective analysis, investigators collected and evaluated data from patients who underwent TBB at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital.
- Trial name
- OCTGTBIPPL (NCT06419114)
- Testing
- Optical Coherence Tomography
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sichuan Provincial People's Hospital
Peripheral Pulmonary Lesion
Diagnostic Value of Confocal Laser Endomicroscopy (CelTouch) for Peripheral Lung Lesions
This study uses CelTouch to explore patients with lung lesions scheduled for lung biopsy. By comparing with preclinical CLE images and pathological images, CLE diagnostic criteria for benign and malignant lung lesions under the…
- Trial name
- NCT07004946
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Guangzhou Medical University
Peripheral Lung Lesions
Difference Strain Ratio Ultrasound Elastography Between Benign and Malignant Peripheral Lung Lesions
Diagnostic accuracy study to investigate the sensitivity and specificity of sonographic elastography using strain ratio to differentiate between benign and malignant peripheral lesions in comparison to biopsy, clinically, or…
- Trial name
- NCT05752227
- Testing
- Transthoracic biopsy, CT chest
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Alexandria University