Clinical trials: Peripheral Lung Lesions
Solitary Pulmonary Nodule, Biopsy, Fine-Needle
iNod System Human Feasibility Assessment
The purpose of this study is to demonstrate feasibility to access, visualize, and obtain specimens adequate for cytology of lung lesions in subjects with suspected lung cancer when using the iNod System.
- Trial name
- iNod (NCT02832284)
- Testing
- iNod System
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Boston Scientific Corporation
Lung Neoplasms, Thoracic Neoplasms
A Multimodality Image-guided System for Peripheral Lung Cancer Diagnosis and Therapy
The goal of this clinical research study is to test the use of a minimally invasive multimodality image-guided (MIMIG) intervention system used for performing a lung biopsy.
- Conditions
- Lung Neoplasms, Thoracic Neoplasms, Neoplasms by Site, Neoplasms
- Trial name
- MIMIG (NCT02111824)
- Testing
- MIMIG System, Indocyanine Green (ICG)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The Methodist Hospital Research Institute
Peripheral Pulmonary Lesions (PPLs), Pulmonary Nodules
Comparative Study of Rotational Cryobiopsy Needle and Automated Biopsy Needle in Transthoracic Biopsy Diagnosing Peripheral Pulmonary Lesions
This study aims to systematically compare the diagnostic efficacy, specimen quality, and complication rates of the cryobiopsy needle technique（CassiII rotational core biopsy） versus the automated biopsy technique in the biopsy of…
- Trial name
- NCT07772479
- Testing
- CassiII rotational core biopsy, Automated biopsy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Cancer
Evaluation of Deployment Capability and Accuracy of an Outside the Scope (OTS), Detachable Catheter System for Ablation of Peripheral Lung Lesions: An Ex-Vivo Human Lung Model Study
A novel OTS detachable probe system carried outside and along the flexible bronchoscope has been developed. Using this novel system, the operator can deploy the probe in the target bronchus and lesion and completely detach the…
- Trial name
- NCT04722432
- Testing
- Outside the Scope (OTS), Detachable Catheter System
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Peripheral Pulmonary Lesion
A Real-World Case Study Evaluating the Efficacy and Safety of RBS Cryobiopsy
The goal of this clinical trial is tois to assess the effectiveness and safety of RBS (Robotic Bronchoscopy System)-assisted cryobiopsy in real-world clinical settings in adult patients (aged ≥18 years) with suspected pulmonary…
- Trial name
- NCT06832930
- Testing
- unicorn robotic bronchoscopy system, Conventional navigation bronchoscopy
- Volunteers
- 200 people
- Sponsor
- Guangzhou Medical University
Peripheral Pulmonary Lesion, Lung Nodule, Solitary
Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT Using Integrated Intraprocedural Imaging
RELIANT 2 is a pragmatic randomized controlled trial. The goal of this study is to compare the diagnostic yield of robotic assisted bronchoscopy with integrated cone beam computed tomography to that of electromagnetic navigation…
- Trial name
- RELIANT 2 (NCT06654271)
- Testing
- Robotic assisted bronchoscopy (RAB), Electromagnetic navigation bronchoscopy (ENB)
- Where
- 4 sites in United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Parenchymal Lesions
Comparing the Diagnostic Yield of Radial EBUS Guided Biopsies When Using a Thick (1.7mm) Vs. Thin (1.4 mm) USS Probe.
Obtaining a tissue sample to diagnose parenchymal lung lesions (PPL) suspected of cancerous origin is of utmost importance. Due to it's markedly favourable safety profile, a bronchoscopic biopsy method called Radial EBUS is…
- Trial name
- R-EBUST2 (NCT02739126)
- Testing
- Radial EBUS biopsy, Types of Radial Ultrasound probes
- Where
- New Zealand
- Volunteers
- 88 people
- Sponsor
- Middlemore Hospital, New Zealand
Pulmonary Coin Lesion
Pilot Study to Measure Lung Biopsy Diagnostic Yield Using Always On Electromagnetic Tip Tracked Devices
The objective of the prospective, multi-center study is to evaluate the ease of use and effectiveness of the SPiN Drive Electromagnetic (EM) Tip Tracked Steerable Devices as a method of sampling subsegmental, less than 3.0 cm…
- Trial name
- ALOSPNDY (NCT01389154)
- Testing
- Lung biopsy using Always On EM Tip Tracked Device
- Sponsor
- Veran Medical Technologies
Carcinoma, Non-Small-Cell Lung
A Study to Examine Biomarkers From Lung and Blood Samples in Participants With Suspected Lung Cancer
The purpose of this study is to assess spontaneous residual viable tumor cells (RVT) in the surgically resected tumor (Non-small cell lung cancer [NSCLC]).
- Trial name
- NCT04951154
- Testing
- Bronchoscopic Biopsy, Blood Sample
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Janssen Research & Development, LLC
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Pulmonary Nodule, Lung Cancer
Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung
This study is designed to evaluate clinical safety and diagnostic accuracy of the robotic-assisted bronchoscopy with biopsy performed with the Monarch™ Endoscopy Platform in a broad range of patients with pulmonary lesions.
- Trial name
- TARGET (NCT04182815)
- Testing
- Robotic assisted bronchoscopy
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 691 people
- Sponsor
- Auris Health, Inc.
Lung Cancer, Lung; Node
Diagnostic Yeld of Ultrathin Bronchoscopy in Peripheral Pulmonary Lesions
The use of an ultrathin bronchoscope (UB) has recently been introduced in the diagnosis of peripheral lung lesions. The use of the UB can be supported by navigation systems such as fluoroscopy, ultrasound guidance…
- Conditions
- Lung Cancer, Lung; Node, Lung Diseases, Lung TB
- Trial name
- NCT05526573
- Testing
- Ultrathin bronchoscopy (MP190F; Olympus Medical Systems, Tokyo, Japan)
- Where
- 3 sites in Italy
- Volunteers
- 148 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Pulmonary Mass
CBCT in Guiding Bronchoscopy in Patients With Lung Lesions
This pilot clinical trial studies how well cone-beam computed tomography (CBCT) works in guiding bronchoscopy in patients with lung lesions.
- Trial name
- NCT02978170
- Testing
- Cone-Beam Computed Tomography
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Pulmonary Nodule, Bronchoscopy
Comparative Performance of Robotic, Electromagnetic Navigation and Fluoroscopy Drives Optimal Diagnostic Strategy for Peripheral Pulmonary Lesions
Currently, the optimal method for Peripheral Pulmonary Lesions (PPL) is uncertain. We aim to compare the diagnostic yield of Robotic Bronchoscopy System (RBS), Electromagnetic Navigation Bronchoscopy (ENB)…
- Trial name
- NCT06701448
- Testing
- robotic bronchosopy, Electromagnetic Navigation Bronchoscopy, Fluoroscopy bronchoscopy
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Guangzhou Medical University
Lung Diseases
Role of Ultrasound Elastography in Differentiation of Peripheral Lung Lesions
Advancements in imaging capacities and the development of a precise puncture-guiding transducer have made transthoracic ultrasonography a useful diagnostic tool for evaluating peripheral subpleural lung tumours.
- Trial name
- NCT05759390
- Testing
- Ultrasound elastography
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Lung Nodules, Peripheral Lung Lesions
Shape-Sensing Robotic-Assisted Bronchoscopy for Diagnosis of Peripheral Pulmonary Nodules in Korea
What is this study about? This study tests a new robotic technology to take tissue samples from lung nodules (small spots in the lungs). Some lung nodules are cancer, but doctors need a tissue sample to know for sure.
- Conditions
- Lung Nodules, Peripheral Lung Lesions, Pulmonary Nodules, Lung Cancers
- Trial name
- ULSAN-ION (NCT07057648)
- Testing
- Shape-sensing Robotic-assisted Bronchoscopy (ssRAB)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ulsan University Hospital
Peripheral Pulmonary Lesions (PPLs)
CLE vs. ROSE for Ex Vivo Lung Biopsy Assessment
The goal of this observational study is to evaluate the diagnostic efficacy of Confocal Laser Endomicroscopy (CLE) compared to Rapid On-Site Evaluation (ROSE) for ex vivo lung biopsy specimens obtained via bronchoscopy.
- Trial name
- NCT07725510
- Testing
- Ex Vivo Confocal Laser Endomicroscopy (CLE) Imaging and Interpretation, Rapid On-Site Evaluation (ROSE) Imaging and Interpretation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Lung Nodule, Lung Mass
Cone Beam CT Guided Robotic Navigational Bronchoscopy
Navigational bronchoscopy (NB) is used to access peripheral and central parenchymal lung lesions via endobronchial and transbronchial approach.
- Conditions
- Lung Nodule, Lung Mass, Lung Cancer
- Trial name
- CBCTRNB (NCT05358041)
- Testing
- Robotic Bronchoscopy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbus Regional Health
Peripheral Pulmonary Nodules
Thin and Ultrathin Bronchoscopy With Transbronchial Needle Aspiration and Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions
To collect data on diagnostic yield of thin and ultrathin bronchoscopes with radial probe endobronchial ultrasound (radial EBUS) and transbronchial needle aspiration (TBNA) during routine standard of care bronchoscopy for…
- Trial name
- NCT04331587
- Testing
- BF-P190 4 mm thin bronchoscope, BF-MP190F 3 mm ultrathin bronchoscope, Radial ultrasound probe (UM S20-17S)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Lung Neoplasms, Pulmonary Neoplasm
ENB Vs. Conventional Bronchoscopy With Fluoroscopy for Safe and Effective Biopsy of Pulmonary Lesions
Evaluate results for participants with lung lesions randomized to either 4D Electromagnetic Navigation Bronchoscopy (4D-ENB) versus Conventional Bronchoscopy with Fluoroscopy for diagnostic biopsy and detection of lung cancer.
- Trial name
- NCT04447482
- Testing
- ENB with image-guided lung biopsy, Conventional Bronchoscopy guided by Fluoroscopy
- Where
- 4 sites in China
- Volunteers
- 212 people
- Sponsor
- Shanghai Youhe Medical Technology Co., Ltd.