Clinical trials: Peripheral Nerve Disorder
Healthy, Peripheral Neuropathic Pain
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food-effect of TRK-750
This is an exploratory, randomised, double-blind, placebo-controlled, Phase I study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effect of single and multiple, ascending oral doses of TRK-750 in…
- Trial name
- NCT03346330
- Testing
- TRK-750
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Toray Industries, Inc
Vestibular Schwannoma, Vestibular Disorder
Longitudinal Recovery of Laboratory, Clinical, and Community-Based Measures of Head and Trunk Control in People With Acquired Vestibulopathy
This study is designed to examine the true impact inner-ear dysfunction has on patient head movement kinematics, activity levels, and participation, and (2) to explore the efficacy of rehabilitation on laboratory, clinical, and…
- Trial name
- NCT04594057
- Testing
- Gaze and Postural Retraining Exercise
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Postherpetic Neuralgia ( PHN ), Lymphatic System Disorder
Early Screening Markers of Herpes Zoster Neuralgia
Herpes zoster (HZ), especially postherpetic neuralgia, is one of the most typical types of clinical neuralgia. The incidence rate of HZ in China is approximately 7.7%. Among them, 29.8% of HZ patients eventually develop PHN.
- Trial name
- NCT07038707
- Testing
- Extract the serum and feces of the patients for standard screening of early biomarkers, Meningeal lymphatic vessel imaging
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Substantial variability exists in the onset, and rate of degeneration across individuals with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS).
- Conditions
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Motor Neuron Disease Progressive Spinal Muscle Atrophy, Primary Lateral Sclerosis, Multiple Sclerosis
- Trial name
- NCT06320444
- Testing
- 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG)
- Where
- Ireland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin
Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)
The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the…
- Conditions
- Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin, Healthy Subjects
- Trial name
- NCT01623141
- Testing
- Pressure Pain measurement
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Chronic Kidney Disease, Renal Osteodystrophy
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients
Sclerostin, the product of the SOST gene, located on chromosome 17, locus q11.2 in humans, was originally believed to be a non-classical Bone morphogenetic protein (BMP) antagonist.Sclerostin was recently identified as a…
- Conditions
- Chronic Kidney Disease, Renal Osteodystrophy, Left Ventricular Hypertrophy
- Trial name
- NCT01382966
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- RFM Renal Treatment Services
Painful Diabetic Neuropathy
Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN
A Phase 1b study to evaluate the safety, tolerability and pharmacokinetics of multiple ascending doses of CNTX-6016 in healthy subjects and a single cohort to evaluate painful diabetic neuropathy.
- Trial name
- NCT04857957
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Carpal Tunnel Syndrome
Avazzia HVPC Bio-Electrical Stimulation Technology (BEST™) Microcurrent CTS RCT
A clinical study at Activated Family Chiropractic \& Wellness, is being proposed to test the efficacy of a novel electrical stimulation platform named the Pro-Sport Ultra® designed by AVAZZIA to relieve pain and improve mobility…
- Trial name
- NCT04271319
- Testing
- BEST™ HVPC microcurrent electrical stimulation PRO-SPORT Ultra® Device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Avazzia, Inc
Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy
The Association Between Cognitive Function and Neuropathy in Individuals With Type 2 Diabetes
The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to…
- Conditions
- Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy, Cognitive Impairment, Diabetes Type 2
- Trial name
- ASCEND (NCT06857994)
- Where
- Denmark
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Radial Palsy
Tendon Transfer for Irreversible Radial Nerve Palsy, Does it Help?Retrospective Cohort From Level-1 Trauma Center.
Radial nerve palsy is associated with serious disability jeopardizing the grasp and power grip accountable to the loss of thumb and fingers extension and loss of active wrist extension respectively.
- Trial name
- NCT03936868
- Testing
- Tendon transfer
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Aga Khan University