Clinical trials: Peripheral Nerve Injuries
Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury
A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury
In this clinical trial, participants with nerve pain after shingles or nerve injury will receive injections with NT 201 or placebo. The purpose is to measure the decrease of nerve pain with NT 201 compared to placebo.
- Trial name
- PaiNT (NCT06091020)
- Testing
- IncobotulinumtoxinA
- Where
- 31 sites in Bulgaria, France and 4 more
- Volunteers
- 123 people
- Sponsor
- Merz Therapeutics GmbH
Spinal Cord Injuries, Peripheral Nerve Injuries
Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)
The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work.
- Trial name
- NCT06672458
- Testing
- MyndMove Short Term Therapy, Conventional Short Term Therapy, MyndMove Long Term Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Peripheral Nerve Injuries, Median Nerve Injury
EMG-Triggered Electrical Stimulation After Median/Ulnar Nerve Repairs
Immobilization following median and/or ulnar nerve repairs results in strength loss in the wrist and finger extensor muscles. Given the critical importance of wrist extension for functional grip, this condition significantly…
- Conditions
- Peripheral Nerve Injuries, Median Nerve Injury, Ulnar Nerve Injury
- Trial name
- NCT07532499
- Testing
- EMG-triggered electrical stimulation, Conventional physiotherapy group
- Volunteers
- 26 people
- Sponsor
- Pamukkale University
Hand, Hand Therapy
Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System
This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later.
- Conditions
- Hand, Hand Therapy, Upper Extremity, Prediction Models
- Trial name
- HANDREHPREDICT (NCT07522060)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Peripheral Nerve Injuries, Neuroma of Nerve Repair
High-Purity Type I Collagen Nerve Wrapping in Peripheral Nerve Procedures: A Prospective Registry
This prospective multicentre observational registry evaluates early clinical outcomes following the use of High-Purity Type I Collagen (HPTC) as a circumferential nerve wrap during peripheral nerve procedures.
- Conditions
- Peripheral Nerve Injuries, Neuroma of Nerve Repair, Nerve Graft; Complications, Mechanical, Peripheral Nerve Decompression Injury
- Trial name
- NCT07360730
- Testing
- High-Purity Type I Collagen (HPTC) Nerve Wrap
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Peripheral Nerve Injuries
Mirror Therapy Integrated With Electrical Stimulation for Cortical Modulations
Peripheral nerve injury is common and can result in loss of sensation and motor function, reduced quality of life, and prolonged time to return to work.
- Trial name
- NCT06209801
- Testing
- Mirror therapy, Neuromuscular electrical stimulation, Motor imagery
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Stroke, TBI
Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments
This study will evaluate the safety and performance of the Spatial StimeMD (SSMD) medical device in people with multiple sclerosis (MS). The SSMD device is intended to support patients through a non-invasive stimulation program.
- Conditions
- Stroke, TBI, Spinal Cord Injury, Peripheral Nerve Damage
- Trial name
- NCT07396922
- Testing
- SSMD, Functional Electrical Stimulation (FES)
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Motion Informatics LTD
Peripheral Nerve Injuries
Non-invasive Therapy to Drive Nerve Regeneration
Peripheral nerve injuries are common and often associated with poor outcomes including incomplete repair, debilitating pain states and compromised function.
- Trial name
- NCT05848778
- Testing
- Acute Intermittent Hypoxia, Normoxia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Alberta
Nerve Injury, Peripheral Nerve Injuries
A Study to Expand the Use of Symani® Surgical System for Peripheral Nerve Repair
The objective of this study is to evaluate the Symani System's safety and effectiveness for microsurgical nerve coaptation, following nerve injuries to the hand.
- Trial name
- REGEN (NCT07084207)
- Testing
- Symani® Surgical System, Manual Surgery
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- MMI (Medical Microinstruments, Inc.)
Peripheral Nerve Injuries
Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting.
- Trial name
- RANGER® (NCT01526681)
- Testing
- Processed Human Nerve Graft, Standard Treatment, Autogenous Nerve Graft, Direct Suture, etc., Autogenous Nerve Graft
- Where
- 49 sites in United States, Austria and 2 more
- Volunteers
- 3,126 people
- Sponsor
- Axogen Corporation
Peripheral Nerve Injury
Mirror Therapy Combined With Contralaterally Controlled Functional Electrical Stimulation for Peripheral Nerve Injury
The goal of this trial is to evaluate the effects of mirror therapy combined with contralaterally controlled functional electrical stimulation on motor recovery and neuroplasticity in patients with peripheral nerve injury.
- Trial name
- NCT06209632
- Testing
- mirror therapy, contralaterally controlled functional electrical stimulation, conventional physiotherapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Peripheral Nerve Injuries
Autologous Human Schwann Cells in Peripheral Nerve Repair
The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) augmentation of nerve autograft repair in participants with severe peripheral nerve injury (PNI).
- Trial name
- NCT03999424
- Testing
- autologous human Schwann cells
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- W. Dalton Dietrich
Flaccid Paresis, Spastic Paresis
Comparing Digitally and Traditionally Made Ankle Foot Orthoses
The research is being done to compare two methods of creating AFOs: 1. The traditional method, which involves manually creating a mold from a plaster cast of the client's limb. This is time-consuming and labor-intensive; and 2.
- Conditions
- Flaccid Paresis, Spastic Paresis, Cerebral Palsy, Stroke
- Trial name
- NCT06828653
- Testing
- Part A First Wear Period: Traditional AFO(s), Part A First Wear Period: Digital AFO(s), Part A Second Wear Period: Traditional AFO(s)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Peripheral Nerve Injuries
Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury
The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial…
- Trial name
- NCT03150511
- Testing
- Tesamorelin 2 Milligrams (MG)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Acute Upper Extremity Trauma
Registry of Avive® Soft Tissue Membrane Utilization in Selected Applications of Acute Trauma of the Upper Extremity
A registry study to evaluate the role of Avive® Soft Tissue Membrane in the management of nerve injury associated with acute trauma in the upper extremity.
- Trial name
- ASSIST (NCT03943134)
- Testing
- Minimally Processed Human Umbilical Cord Membrane, Standard Surgical Procedures
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Axogen Corporation
Peripheral Nerve Injury, Crush Injury
4-AP Peripheral Nerve Crossover Trial
The purpose of this study is to evaluate the role of single dose 4-aminopyridine (4-AP) on the diagnosis of severing vs non-severing nerve injury after peripheral nerve traction and/or crush injury.
- Trial name
- NCT06003166
- Testing
- 4-Aminopyridine
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Arizona
Chronic Pain, Peripheral Neuropathy
StimRouter Registry Clinical Protocol
This Registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes…
- Conditions
- Chronic Pain, Peripheral Neuropathy, Nervous System Diseases, Peripheral Nervous System Diseases
- Trial name
- NCT03913689
- Testing
- StimRouter Neuromodulation System
- Where
- 9 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bioness Inc
Leg Pain, Peripheral Nerve Discontinuities
Effect of Nerve Stimulation on Sciatic Nerve Injury Pediatric Patients
Brief Summary The goal of this study is to learn if Faradic Nerve Stimulation (FNS) can help children recover from a condition called Post-Injection Sciatic Nerve Injury (PISNI).
- Conditions
- Leg Pain, Peripheral Nerve Discontinuities, Muscle Weakness, Sciatic Nerve Compression
- Trial name
- PISNI (NCT06781060)
- Testing
- Faradic Nerve Stimulation Therapy+Standard Physiotherapy, Physiotherapy Standard Treatment with TENS machine therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Azeem Hospital, Multan
Peripheral Nerve Injury(Ies)
Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma
This is a multi-center prospective observational study that will capture detailed information about the treatment and long term outcomes of 250 patients with PNI resulting from upper extremity trauma.
- Trial name
- Nerve (NCT02718768)
- Where
- 17 sites in United States
- Volunteers
- 242 people
- Sponsor
- Major Extremity Trauma Research Consortium
Spinal Cord Injury + Peripheral Nerve Diseases
Assessment of Neuropathic Pain
Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases.
- Trial name
- NCT02138344
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Zurich