Clinical trials: Peripheral Nerve Injury (PNI)
Peripheral Nerve Injuries
Expanded Access - Autologous Human Schwann Cells in Peripheral Nerve Repair
Emergency expanded access for a single patient was granted to receive autologous human Schwann cell (ahSC) augmentation of nerve autograft repair after severe peripheral nerve injury (PNI).
- Trial name
- NCT04465929
- Testing
- Autologous Human Schwann Cells
- Where
- United States
- Sponsor
- W. Dalton Dietrich
Non-diabetic Painful Peripheral Polyneuropathy, Postherpetic Neuralgia (PHN)
A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment
This study is comparing the efficacy and tolerability of Qutenza with that of pregabalin in patients suffering from peripheral neuropathic pain.
- Conditions
- Non-diabetic Painful Peripheral Polyneuropathy, Postherpetic Neuralgia (PHN), Peripheral Nerve Injury (PNI)
- Trial name
- ELEVATE (NCT01713426)
- Testing
- Qutenza, Pregabalin
- Where
- 98 sites in Armenia, Austria and 20 more
- Volunteers
- 568 people
- Sponsor
- Astellas Pharma Europe Ltd.
Peripheral Nerve Injuries
Autologous Human Schwann Cells in Peripheral Nerve Repair
The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) augmentation of nerve autograft repair in participants with severe peripheral nerve injury (PNI).
- Trial name
- NCT03999424
- Testing
- autologous human Schwann cells
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- W. Dalton Dietrich
Peripheral Nerve Injury, Postherpetic Neuralgia
Study of Possible Changes in QST After Application of Capsaicin on Patients With Peripheral Neuropathic Pain
The treatment of neuropathic pain ist still a challenge. A new promising therapy is the use of capsaicin on skin. The investigators first experiences with capsaicin in patients with peripheral nerve injury showed changes in the…
- Trial name
- NCT01596491
- Testing
- quantitative sensory testing (QST)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Ruhr University of Bochum
Peripheral Nerve Injury
Safety and Efficacy of Autologous Human Schwann Cell (ahSC) Augmentation in Severe Peripheral Nerve Injury (PNI)
The primary purpose of this research study is to evaluate the safety and possible harms of injecting one's own Schwann cells along with nerve auto-graft after a severe injury to a major nerve has occurred.
- Trial name
- NCT05541250
- Testing
- Autologous Human Schwann Cell
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- W. Dalton Dietrich
Peripheral Nerve Injuries
Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)
The overall objective of this study is to determine the safety of PEG fusion when used with primary repair or reconstruction in patients with an acute upper extremity peripheral nerve injury.
- Trial name
- NCT04789044
- Testing
- NTX-001
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Major Extremity Trauma Research Consortium
Neuropathic Pain
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
The goal of this clinical trial is to learn if ASCT-83 is safe and well-tolerated and measure how ASCT-83 is absorbed, distributed, and eliminated from the body over time. The study will be conducted in healthy adults.
- Trial name
- NCT07363395
- Testing
- ASCT-83
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Alcamena Stem Cell Therapeutics
or Peripheral Nerve Injury (PNI), Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN)
Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch
The Summary of product characteristics (SmPC) for QUTENZA advises that topical anaesthetic is applied prior to the application of QUTENZA.
- Trial name
- LIFT (NCT01416116)
- Testing
- QUTENZA, Lidocaine, Tramadol
- Where
- 20 sites in Belgium, Czechia and 5 more
- Volunteers
- 122 people
- Sponsor
- Astellas Pharma Inc
Peripheral Nerve Injury Upper Limb, Peripheral Nerve Injury (PNI)
This Study Will Evaluate the Effectiveness of NTX-001, a Surgical Nerve Repair Product When Used in People With Upper Extremity Nerve Lacerations.
NTX-001 is a single use surgical product intended for use in conjunction with standard suture neurorrhaphy of severed nerves in patients between 18 and 80.
- Trial name
- NCT06616025
- Testing
- NTX-001 (PEG-Fusion)
- Where
- 25 sites in United States
- Volunteers
- 98 people
- Sponsor
- Neuraptive Therapeutics Inc.