Clinical trials: Peripheral Nervous System Diseases
Piriformis Syndrome
Comparative Effects of PIR and PFS on Pain, Hip ROM, and Disability in Piriformis Syndrome
This randomized clinical trial evaluates the effectiveness of Post-Isometric Relaxation (PIR) and Post-Facilitation Stretching (PFS) for managing pain, improving hip abduction and internal rotation, and enhancing functional…
- Trial name
- PIR-PFS RCT (NCT07255053)
- Testing
- Post Isometric Relaxation (PIR), Post Facilitation Stretching (PFS)
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Faisalabad
Cognitive Decline, Cognitive Dysfunction
Brain Vascular and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of transcranial photobiomodulation on indices of cerebral vascular health and neurocognitive function.
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
- Trial name
- NCT06497413
- Testing
- Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Postoperative Pain, Postherniotomy Pain
Neurophysiological Characterization of Postherniotomy Pain
Sensory function is different in persistent postherniotomy pain patients than in operated controls, suggesting this to be a neuropathic pain syndrome.
- Conditions
- Postoperative Pain, Postherniotomy Pain, Neuropathic Pain
- Trial name
- NCT00719368
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Carpal Tunnel Syndrome
Treatment Intervention of Patients With Carpal Tunnel Syndrome (CTS)
The purpose of this study was to investigate the effectiveness of KT versus TENS combining self-myofascial stretching in treatment of CTS through clinical, functional assessment and sensory measurements.
- Trial name
- NCT06464809
- Testing
- kinesio taping (KT)
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Carpal Tunnel Syndrome
Median Nerve Strain and Applied Pressure Measurement in the Carpal Tunnel Syndrome Patients
The aim of this study is to investigate diagnostic accuracy of median nerve strain and applied pressure measurement . Idiopathic carpal tunnel syndrome patients and healthy controls will be evaluated by ultrasound.
- Trial name
- NCT04027998
- Testing
- strain and applied pressure measurement
- Where
- Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tokyo Medical University
Chronic Pain
Sensory Abnormalities in Post-surgical Peripheral Neuropathy
The concept of normality is a cornerstone in medical practice and research. As an example, in clinical chemistry, a laboratory value based on a plasma sample exceeding the +/- 1.96 x standard deviation (SD) range, referenced from…
- Trial name
- NCT03966677
- Where
- Denmark
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Carpal Tunnel Syndrome
Case-control Study on Individual Risk Factors of CTS
This study is conducted to observe the characteristics of the risk factors of CTS in Chinese population.
- Trial name
- NCT03166033
- Testing
- the disease
- Where
- China
- Volunteers
- 6,048 people, healthy volunteers welcome
- Sponsor
- Fudan University
Neuropathic Pain
A Study to Investigate the Pharmacodynamic Effects of CT327 on Intra-dermal Nerve Growth Factor (NGF) and Evoked Pain Responses, in Healthy Male Volunteers
The primary objective of this study is to compare the effect of CT327 to placebo against experimental induced superficial, deep and hyperalgesic pain.
- Trial name
- NCT01243307
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Creabilis SA
Cardiovascular Diseases, Heart Diseases
The North Kynouria Project
The North Kynouria Project was initiated to study cardiovascular/stroke risk factors by employing mass screening and long-term surveillance of an adult population in the municipality of North Kynouria, in the county of Arcadia…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Disease, Coronary Disease
- Trial name
- NCT06115213
- Testing
- Patient counselling
- Where
- Greece
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Diaphragm Paralysis
The Effect of Interscalene Peripheral Nerve Block With 0.25% Bupivacaine vs 0.125% Bupivacaine on Lung Function
Peripheral nerve blocks are used to provide post-operative pain relief. Nerve blocks in the neck, in the interscalene area, provide pain relief after shoulder surgery but can cause temporary weakness or paralysis of the…
- Trial name
- NCT01429584
- Testing
- interscalene nerve block with 0.25% bupivacaine, interscalene block with 0.125% bupivacaine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Neuroscience
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] AZD2423 in Volunteers
Phase I study to evaluate the excretion of radioactivity, the metabolic profile, pharmacokinetics, safety and tolerability following a single oral administration of [14C]AZD2423 in healthy male volunteers aged 50 to 65 years…
- Trial name
- ADME (NCT01223014)
- Testing
- AZD2423
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
The Evaluation of Efficacy and Safety of Rituximab in Refractory CIDP Patients With IgG4 Autoantibodies
To evaluate the efficacy and safety of rituximab (genetical recombination) intravenously administered to CIDP patients with positive or negative IgG4 autoantibody.
- Trial name
- RECIPE (NCT03864185)
- Testing
- Rituximab (genetical recombination)
- Where
- 4 sites in Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Neuropathic Pain, Cortical Excitability
Analysis of Cortical Excitability in Neuropathic Pain
The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.
- Trial name
- NCT00789347
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Postoperative Pain, Postoperative Complications
Comparison of the Efficacy of Peripheral Nerve Blocks in Major Open Gynaecological Cancer Surgery
The aim of this prospective randomized study was to compare the effectiveness of subcostal transversus abdominis plane block or rectus sheath block applied in addition to posterior transversus abdominis plane block for…
- Conditions
- Postoperative Pain, Postoperative Complications, Analgesia, Regional Anesthesia Morbidity
- Trial name
- NCT06342076
- Testing
- Patients undergoing subcostal transversus abdominis plane block and posterior transversus abdominis plane block, Patients undergoing rectus sheat block and posterior transversus abdominis plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Femoral Neuropathy
Femoral Neuropathy After Anterior Cruciate Ligament Reconstruction: Femoral Nerve Block vs Patient-controlled Analgesia (PCA)
Femoral neuropathy after anterior cruciate ligament reconstruction with femoral nerve block may be as high as 24% at 6 postoperative weeks when evaluated prospectively and systematically through a clinical neurological and an…
- Trial name
- NCT01321138
- Testing
- Femoral nerve block, PCA morphine
- Where
- Switzerland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Lumbar Radiculopathy
Study of the Diagnostic Accuracy of the Neurodynamic Tests in Patients With Lumbar Radiculopathy
Lumbar radiculopathy is a relevant cause of disability and morbidity, accounting for between 23 and 57% of the cases of patients with low back pain and representing a significant expense due to the sick leave and health care that…
- Trial name
- NCT05636917
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Amyotrophic Lateral Sclerosis
Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive muscle weakness and eventual death.
- Trial name
- NCT03090932
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Carpal Tunnel Syndrome
Gabapentin and Neural Mobilization Pain Reduction Effect Compared to Only Gabapentine
In the present investigation the pain reduction effects of a physiotherapy technique combined with pharmaceutical gabapentin treatment will be compared to those produced by gabapentin (only) treatment, in subjects who suffer the…
- Trial name
- NCT06778798
- Testing
- Median nerve neural mobilization and oral gabapentin, Gabapentin 300mg
- Where
- Venezuela
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
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