Clinical trials: Peripheral Neuropathy
Small Fiber Neuropathy, Diabetic Neuropathies
Skin Biopsy in the Diagnosis of Small Fiber Neuropathy in Chinese Patients With Diabetes
To detect small fiber neuropathy in patients with possible or established diabetic peripheral neuropathy (DPN) by skin biopsy and explore clinical characteristics and pathological features in Chinese patients with diabetes.
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Diabetes Mellitus
- Trial name
- NCT04071535
- Testing
- sudoscan、nerve conduction tests
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cervical Radiculopathy
The Relationship Between Cervical Radiculopathy and Eye-hand Coordination
this study will be conducted to investigate if there is a relationship between cervical radiculopathy and eye-hand coordination.
- Trial name
- CR (NCT06169618)
- Testing
- cervical radiculopathy, normal group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
A Study of Clinical and Genetic Mutations in a Family of Neuromyotonia, so Called Isaac's Syndrome
Inherited Myokymia: A Clinical and Genetic Study of a Family
Neuromyotonia (NMT), so called Isaac's syndrome, is a rare disorder in which hyperexcitability of peripheral motor nerves leads to intermittent muscle contractions.
- Trial name
- NCT01250704
- Where
- 3 sites in Taiwan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Cubital Tunnel Syndrome
Cubital Tunnel Syndrome and Diffusion MRI: A Proof of Concept Study
Cubital Tunnel Syndrome (CTS) results from compression of the ulnar nerve at the elbow (colloquially termed the "funny bone"). CTS affects up to 6% of the population and 6000 patients undergo surgery annually in the UK.
- Trial name
- NCT04470245
- Testing
- magnetic resonance imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Diabetic Foot, Diabetic Neuropathies
Peripheral Protective Sensation in Type 2 Diabetes Mellitus
The aim of our study was to investigate the effect of sole sensation on peripheral muscle strength, functional capacity, balance and physical activity level in individuals with Type 2 Diabetes Mellitus.
- Trial name
- NCT05904262
- Testing
- Foot Sole Sensation Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Neuropathic Pain
Brain Activation During Thermal Stimulation in Neuropathic Pain
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following…
- Trial name
- NCT00525018
- Testing
- contact heat evoked potential stimulator
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neuropathic Pain, Complex Regional Pain Syndrome
IV Lidocaine Infusion for Neuropathic Pain
The investigators will conduct a retrospective cohort study of patients who have undergone i.v. lidocaine infusions in the previous 2 years for suspected neuropathic pain of heterogeneous origin.
- Conditions
- Neuropathic Pain, Complex Regional Pain Syndrome, Chronic Pain
- Trial name
- NCT05731739
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Axonal Change, Neuronal, Pain
Effect of the Kv7-channel Opener Flupirtine on the Excitability of Human Peripheral Myelinated Axons in Vivo
Slow axonal Kv7 potassium channels are found along unmyelinated axons and at the nodes of Ranvier of myelinated axons in peripheral nerve.
- Trial name
- NCT01450865
- Testing
- flupirtine
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Carpal Tunnel Syndrome (CTS)
Ultrasound Elastography of Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve compression disorder in adults. Although electromyography (EMG) is the current gold standard for diagnosis, it is invasive, time-consuming, and may yield…
- Trial name
- UE-CTS (NCT07486284)
- Testing
- Ultrasound Elastography
- Where
- Vietnam
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Da Nang Family General Hospital
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Neuropathy in Cancer Patients
The purpose of this prospective study is to perform Nerve conduction test, Vitamin D, Vitamin B12 and NADPH oxidase 4(NOX4) expression to assess severity of chemotherapy induced Peripheral neuropathy (CIPN) in solid cancer (Head…
- Trial name
- CIN (NCT06491082)
- Testing
- Cisplatin, Carboplatin, Paclitaxel, Docetaxel
- Where
- India
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Swami Rama Himalayan University
Neuropathic Pain, Cancer
Vulnerability and Risk of Neuropathic Pain in Cancer
Successive and repeated therapeutic interventions during cancer management - surgery, chemotherapy, radiotherapy - can all, to varying degrees, generate acute pain, central pain sensitization and chronic pain.
- Conditions
- Neuropathic Pain, Cancer, Predictive
- Trial name
- CANOPY (NCT06511674)
- Testing
- Cognitive-emotional and pain assessments
- Where
- 19 sites in France
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder
Gastrointestinal Motility Among Diabetes Patients
Gastrointestinal (GI) symptoms including vomiting, nausea, abdominal pain, constipation or chronic diarrhea affect a large number of patients with diabetes mellitus (DM).
- Conditions
- Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus, Change of Transit or Circulation
- Trial name
- NCT02573519
- Testing
- 11C Donepezil PET/CT scan, 3D-Transit, 3D-Transit during treatment with Pyridostigmine
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Pain, Pain, Chronic
Investigating Biological Targets, Markers, and Intervention for Chronic Pain
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of chronic pain, and therapeutic targets using integrative health treatments.
- Conditions
- Chronic Pain, Pain, Chronic, Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT04625504
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Safety, Tolerability, and PK of AH-008 Following Single Ascending Dose in Healthy Subjects
This is a Phase 1, first-in-human (FIH), randomized, double-blind, placebo-controlled, parallel-group, single ascending dose (SAD) study to evaluate the safety, tolerability, and pharmacokinetics of AH-008 administered as a…
- Trial name
- NCT07697560
- Testing
- AH-008 for Injection, 150 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AnHorn Medicines Co. Ltd.
Carpal Tunnel Syndrome
Decision Making in Hypothetical Carpal Tunnel Syndrome
Participants will be presented with a hypothetical scenario of carpal tunnel and asked to make a decision for that case.
- Trial name
- NCT03730376
- Testing
- Cost Information
- Where
- United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Stanford University
Carpal Tunnel Syndrome
Musculoskeletal Health of the Upper Extremity in Emerging Health Professionals
Carpal tunnel syndrome is the most expensive upper extremity work-related musculoskeletal disorder, impacting 10 million people annually and costing employers up to $113,695 per incident.
- Trial name
- NCT02587897
- Testing
- Academic Coursework, Work-Related Hand Activities
- Where
- 3 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Chronic Noncancer Pain
Integrating Patient Reported Outcomes (I-PRO) Study for Multidisciplinary Pain Care
The purpose of this study is to assess the impact of clinician education, electronic health record integrated patient reported outcomes, and electronic health record integrated decision support on pain-related care quality…
- Trial name
- I-PRO (NCT02188667)
- Testing
- Providers of Novel Care, Providers of Usual Care
- Where
- 4 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Florida
Peripheral Nervous System Diseases
Evaluate the Safety and Pharmacokinetics of Ricolinostat
This study is an open-label, phase I clinical study to evaluate the safety and pharmacokinetics of ricolinostat in healthy Chinese adult subjects.
- Trial name
- NCT05193851
- Testing
- ricolinostat
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Beijing 3E-Regenacy Pharmaceuticals Co., Ltd.
Spinal Cord Injuries, Pain, Neuropathic
Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain…
- Conditions
- Spinal Cord Injuries, Pain, Neuropathic, Nociceptive Pain, Neuropathy
- Trial name
- NCT06443281
- Testing
- Neurophysiology, Cardiovascular test, Experimental pain paradigms
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cervical Radiculopathy
Effectiveness of Neck Isometric Exercises and Cervical Mobilization on Cervical Radiculopathy
Effectiveness of neck isometric exercises and cervical mobilization will be compared to observe the efficacy of these techniques on cervical radiculopathy
- Trial name
- NCT05884567
- Testing
- Isometric exercises, Mobilization
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neuro Counsel Hospital, Pakistan