Clinical trials: Peripheral Neuropathy Due to Chemotherapy
Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer Stage II
Effect of Hemp-CBD on Patients With CIPN
The purpose of this study is to assess the effect of a hemp-based cannabidiol (CBD) product, Ananda Hemp Spectrum Gelcaps, on the severity and duration of chemotherapy-induced neuropathy (CIPN) among non-metastatic breast…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Breast Cancer
- Trial name
- Coala-T-CBD (NCT04398446)
- Testing
- Hemp-based CBD
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Main Line Health
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Biomarkers in Chemotherapy-Induced Peripheral Neurotoxicity
This pilot study will attempt to establish the feasibility of using tissue oxygen measurements and the protein, neurofilament light chain (NF-L), as potential biomarkers for chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- CIPN (NCT03348956)
- Testing
- EPR Oximetry
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm
Evaluating a Mobile Health Application Intervention for Caregiver Instruction in Manual Therapy for Chemotherapy-Induced Peripheral Neuropathy
This clinical trial assesses the impact of a family caregiver-delivered massage technique for use in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN).
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
- Trial name
- NCT06945380
- Testing
- Best Practice, Comparator Program, Best Practice, Usual Care, Internet-Based Intervention
- Where
- United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chemotherapy-induced Peripheral Neuropathy
Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)
The purpose of this clinical trial is to compare the efficacy of twice daily applications of ATX01 (10% \& 15%) versus placebo during a 12-week treatment period in treating chemotherapy-induced peripheral neuropathy (CIPN) in…
- Trial name
- ACT (NCT05593614)
- Testing
- ATX01 10%, ATX01 15%
- Where
- 43 sites in United States, Belgium and 5 more
- Volunteers
- 276 people
- Sponsor
- AlgoTherapeutix
Cancer, Adults
Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
CYCLE-CIPN is a proof-of-concept study designed to evaluate whether a prescribed aerobic exercise intervention has the potential to reduce the symptoms and functional impact of CIPN.
- Trial name
- CYCLE-CIPN (NCT07150117)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Multiple Myeloma, Chemotherapy-Induced Peripheral Neuropathy
Long Non-coding RNA (lncRNA) ZFAS1-Mediated Mechanism of Roasted Nux Vomica in Intervening Bortezomib-Induced Peripheral Neuropathy
This study aims to evaluate the efficacy and safety of Roasted Nux Vomica Capsules in the treatment of BIPN in patients with multiple myeloma.
- Trial name
- ZFAS1-BIPN (NCT07614243)
- Testing
- Roasted Nux Vomica Capsules
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Breast Cancer, Neuropathy;Peripheral
Efficacy and Safety of HILOTERM® Device for the Prevention of Peripheral Neuropathy
Taxol is a very effective drug in breast cancer, but it can cause peripheral neuropathy (PN). This toxicity is often dose-limiting.
- Trial name
- NCT06422949
- Testing
- Hilotherm® Cooling treatment
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Identification of Chemotherapy-induced Peripheral Neuropathy
The main goal of this trial is to identify the optimal cut-off score of a Scoring System to discriminate between moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) and no CIPN in breast cancer survivors…
- Trial name
- NEURO-BREAC (NCT07148336)
- Testing
- Symptom-based scoring system
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University Hospital Schleswig-Holstein
Gynecological Cancers, Peripheral Neuropathy Due to Chemotherapy
The Effect of Cryocompression on Peripheral Neuropathy in Patients Receiving Chemotherapy for Gynecological Cancer
Study Design: This study is designed as a prospective, randomized controlled experimental study aiming to determine the effect of cryocompression therapy, applied during chemotherapy, on peripheral neuropathy symptoms in women…
- Trial name
- CryoPN (NCT07131618)
- Testing
- cryocompression
- Volunteers
- 78 people
- Sponsor
- Mersin University
Peripheral Neuropathy Due to Chemotherapy
Preventive Approach Using Venlafaxine
Peripheral and Motor neuropathy represent a main obstacle for a better quality of life for cancer patients, Venlafaxine is introduced in a new dosing regimen for treating of oxaliplatin and taxanes induced peripheral neuropathy…
- Trial name
- NCT05875610
- Testing
- Venlafaxine 75 MG, Gabapentin 400 mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mit Ghamr Oncology Center
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Effect of Immersive Virtual Reality on Postural Control and Risk of Fall in Patients With Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of functional disability in cancer survivors. Patients with CIPN typically present with numbness, tingling, burning pain, and loss of proprioception, particularly…
- Trial name
- NCT07854574
- Testing
- The intervention will consist of conventional physical therapy exercise, Immersive Virtual Reality
- Volunteers
- 40 people
- Sponsor
- Cairo University
Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy, Chemotherapy-induced
Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy
Some patients receiving taxane-based chemotherapy experience numbness, tingling, or pain in their hands and feet, known as chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07423390
- Testing
- Mecobalamin
- Where
- 4 sites in China
- Volunteers
- 326 people
- Sponsor
- Qinghai Red Cross Hospital
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
CIPN in Early Stage Breast Cancer Patients
Chemotherapy uses anti-cancer drugs to destroy cancer cells and is a common treatment for many cancers. Taxanes are the most widely used chemotherapy drugs given to breast cancer patients.
- Trial name
- NCT05441722
- Testing
- Exercise prehabilitation
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Northumbria University
Chemotherapy-induced Peripheral Neuropathy
Proof of Principle Study Evaluating Gonyautoxins NEURO SERUM, on Chemotherapy-induced Peripheral Neuropathy
Proof-of-concept study to assess the effects of gonyautoxins (PSP NEURO SERUM) on safety and tactile sensitivity on patients with chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT05052398
- Testing
- PSP NEURO SERUM
- Where
- 9 sites in Brazil
- Volunteers
- 52 people
- Sponsor
- Algenis SpA
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Neuropathy in Cancer Patients
The purpose of this prospective study is to perform Nerve conduction test, Vitamin D, Vitamin B12 and NADPH oxidase 4(NOX4) expression to assess severity of chemotherapy induced Peripheral neuropathy (CIPN) in solid cancer (Head…
- Trial name
- CIN (NCT06491082)
- Testing
- Cisplatin, Carboplatin, Paclitaxel, Docetaxel
- Where
- India
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Swami Rama Himalayan University
Neuropathic Pain, Chemotherapy Effect
Prevention of Paclitaxel-induced Neuropathic Pain in Patients With Planned Paclitaxel Chemotherapy (PrevTel)
Phase IIa clinical trial will be conducted with patients requiring in-label paclitaxel-chemotherapy due to ovarian or breast cancer.
- Trial name
- PrevTel (NCT05322889)
- Testing
- Telmisartan tablets
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Dr. Frank Behrens
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
Involvement of SK3 Calcium Channel in Taxane Neuropathy
Taxane neuropathy is a common and long-term side effect of long-term morbidity in patients surviving cancer. No preventive or symptomatic treatment has been shown to be effective.
- Conditions
- Breast Cancer, Chemotherapy-induced Peripheral Neuropathy, Prostate Cancer
- Trial name
- NEUROTAX (NCT03816904)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Tours
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Safety, Tolerability, and PK of AH-008 Following Single Ascending Dose in Healthy Subjects
This is a Phase 1, first-in-human (FIH), randomized, double-blind, placebo-controlled, parallel-group, single ascending dose (SAD) study to evaluate the safety, tolerability, and pharmacokinetics of AH-008 administered as a…
- Trial name
- NCT07697560
- Testing
- AH-008 for Injection, 150 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AnHorn Medicines Co. Ltd.
Chemotherapy-induced Peripheral Neuropathy, Quality of Life
International CIPN Assessment and Validation Study
This is an observational study of chemotherapy-induced peripheral neurotoxicity (CIPN) patients to be investigated prospectively in order to assess responsiveness of a set of outcome measures in an international multi-center…
- Trial name
- ICAVS (NCT04633655)
- Testing
- outcome measures for CIPN testing
- Where
- 30 sites in United States, Australia and 14 more
- Volunteers
- 1,000 people
- Sponsor
- University of Milano Bicocca
Malignant Solid Neoplasm
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy
This phase III trial compares the effect of 3 study approaches in preventing chemotherapy-induced peripheral neuropathy: 1) cryocompression, 2) continuous compression, and 3) low cyclic compression.
- Trial name
- ICE COMPRESS (NCT05642611)
- Testing
- Biospecimen Collection, Cryocompression Therapy, Pneumatic Compression Therapy
- Where
- 36 sites in United States
- Volunteers
- 777 people
- Sponsor
- SWOG Cancer Research Network