Clinical trials: Peripheral Neuropathy Pain
Sciatica, Sciatica Due to Intervertebral Disc Disorder
Transforaminal Epidural Injection in Acute Sciatica
Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery.
- Conditions
- Sciatica, Sciatica Due to Intervertebral Disc Disorder, Sciatic Radiculopathy
- Trial name
- TEIAS (NCT03924791)
- Testing
- Lidocaine, Methylprednisolone Acetate, Dexamethasone
- Where
- 2 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- C.L.A.Vleggeert-Lankamp
Neuropathic Pain
DOLORisk: Research on Risk Factors and Determinants for Neuropathic Pain
Patients with neuropathic pain of multiple etiologies and a control cohort of patients with the same neuropathic entities who did not develop neuropathic pain are examined clinically, phenotyped with QST and questionnaires.
- Trial name
- NCT04888455
- Testing
- Quantitative sensory testing (QST)
- Where
- Germany
- Volunteers
- 1,550 people
- Sponsor
- University of Kiel
Cervical Radiculopathy
Effects of DRT on Neck Pain, ROM, and Chest Expansion in Patients With CR
This randomized controlled trial aims to determine the effects of the diaphragmatic release technique on neck pain, cervical range of motion, and chest expansion in patients with cervical radiculopathy.
- Trial name
- NCT07628348
- Testing
- Diaphragmatic Release Technique, Traditional Physical Therapy
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Pain, Intractable, Facial Pain
CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain
The CONCEPT study has been designed to evaluate the safety and the efficacy of Motor Cortex Stimulation (MCS) with a new cortical lead (circular lead, eight electrodes, Medtronic Inc, Minneapolis, USA) in the treatment of…
- Trial name
- NCT00122915
- Testing
- Cortical lead, 8 electrodes (Model 2976) with Synergy neurostimulator
- Where
- 11 sites in Austria, Belgium and 2 more
- Volunteers
- 104 people
- Sponsor
- MedtronicNeuro
Cervical Radicular Pain, Cervical Radiculopathy
Effects of Mckenzie Exercises and Neural Flossing Technique in Patients With Cervical Rediculopathy
The primary objective of this research was to conduct a comparative analysis of the outcomes following McKenzie therapy and neural mobilization in individuals diagnosed with cervical radiculopathy
- Trial name
- NCT07592715
- Testing
- McKenzie Exercise, Neural Flossing
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Elite College of Management Sciences, Gujranwala, Pakistan
Pain
Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain
The purpose of the study is to evaluate the efficacy and safety of OraVescent fentanyl treatment compared to placebo treatment monthly over a 12-week treatment period in alleviating breakthrough pain (BTP) in opioid-tolerant…
- Trial name
- NCT00343733
- Testing
- OraVescent Fentanyl
- Where
- 21 sites in United States
- Volunteers
- 120 people
- Sponsor
- Cephalon
Essential Tremor, Dystonia
Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders
The aim of this study is to asses the efficacy and the clinical safety of the transcranial magnetic resonance guided high intensity focused ultrasound system ExAblate 4000, InSightec Ltd.
- Conditions
- Essential Tremor, Dystonia, Parkinson's Disease
- Trial name
- NCT01698450
- Testing
- Non-invasive intervention with focused ultrasound (ExAblate 4000)
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Children's Hospital, Zurich
Carpal Tunnel Syndrome, Susceptibility to
Non-surgical Intervention for Carpal Tunnel Syndrome
This randomized controlled trial graduate student research study will explore the effect of non-surgical intervention of the dorsal application of Kinesio Tape for carpal tunnel syndrome, and forearm wrist hand pain.
- Trial name
- NCT03360344
- Testing
- Kinesio 12 inch Tape, Kinesio 4 inch Tape, Cock up Splint and Lumbrical exercises
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Morton's Neuroma, Pain Management
Cryoanalgesia for the Treatment of Pain in Subjects With Morton's Neuroma
This is a Proof-of-Concept Trial to define the safety, efficacy and feasibility of a cryoanalgesic device (iovera°®) for the treatment of pain in subjects diagnosed with Morton's Neuroma, who have failed conservative therapies.
- Trial name
- NCT05604144
- Testing
- Cryoanalgesia (iovera°®)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Northern California Research Trials, Inc.
Chemotherapy-induced Peripheral Neuropathy
Menthol In Neuropathy Trial
Patients will be recruited who have peripheral neuropathy due to chemotherapy. They will be given a blinded treatment of gel containing either menthol (3%) or placebo to be applied for 6 weeks, twice a day.
- Trial name
- MINT (NCT04276727)
- Testing
- MINT study IMP
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Edinburgh
Radiculopathy, Lumbosacral Region, Back Pain With Radiation
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by…
- Conditions
- Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
- Trial name
- NCT05721027
- Testing
- Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Peripheral Nervous System Diseases, Chronic Pain
Chronic Neuropathy Following Chemotherapy
This is a clinical study which is a follow-up of a previous prospective questionnaire study. All patients who previously participated in the study will receive a new questionnaire and will be invited for a clinical examination.
- Trial name
- DOLORISKCIPN (NCT02654691)
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- Danish Pain Research Center
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radiculopathy
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with a specific type of leg pain.
- Trial name
- NCT03372161
- Testing
- SP-102
- Where
- 37 sites in United States
- Volunteers
- 401 people
- Sponsor
- Scilex Pharmaceuticals, Inc.
Peripheral Nerve Injuries
Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries
The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g.
- Trial name
- NCT03082820
- Testing
- Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST), Nerve conduction studies (NCS)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Sciatica
Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department
Currently, Paracetamol and Ibuprofen are widely used by emergency physicians in Turkey for the pain treatments. The objective of the study was to assess whether intravenous Paracetamol has superior Sciatica pain reduction will…
- Trial name
- NCT02777320
- Testing
- paracetamol, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Pamukkale University
Carpal Tunnel Syndrome
Ultrasound-guided Dextrose Injection Versus Dextrose With Methylprednisolone in Carpal Tunnel Syndrome
The goal of this prospective, randomized, double-blinded, head-to-head comparative study is to compare the efficacy of ultrasound-guided 4 ml 5% dextrose perineural injection versus 3 ml 5% dextrose with 1 ml 40 mg/ml…
- Trial name
- NCT06045013
- Testing
- 5% dextrose injection, 5% dextrose injections with methylprednisolone acetate 40 mg/ml
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- General and Veteran Hospital Croatian Pride Knin
Carpal Tunnel Syndrome (CTS), Mobility
Additional Effects of Shockwave Therapy Along With Median Nerve Gliding Exercises in Patient With Carpal Tunnel Syndrome.
Carpal Tunnel Syndrome (CTS) is a widespread condition resulting from the compression of the median nerve, causing significant pain, numbness, and weakness in the hand.This study decisively evaluates the impactful effects of…
- Conditions
- Carpal Tunnel Syndrome (CTS), Mobility, Hand Functions
- Trial name
- NCT07317024
- Testing
- NERVE GLIDING EXERCISES, SHOCKWAVE THERAPY
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Foundation University Islamabad
Herpes Zoster, Neuralgia
NGX-4010 for the Treatment of Postherpetic Neuralgia
The purpose of the study is determine if an investigational drug, NGX-4010 (high-concentration capsaicin dermal patches) is effective in treating pain associated with post-herpetic neuralgia (PHN).
- Conditions
- Herpes Zoster, Neuralgia, Pain, Peripheral Nervous System Diseases
- Trial name
- NCT00061776
- Testing
- Capsaicin Dermal Patch
- Where
- 28 sites in United States
- Volunteers
- 300 people
- Sponsor
- NeurogesX
Type 2 Diabetes
The Effect of Acupressure on Polyneuropathy-related Pain and Sleep Quality
This study aimed to determine the effect of acupressure on polyneuropathy-related pain and sleep quality in patients with type 2 diabetes. A randomized controlled experimental design was employed in the study.
- Trial name
- NCT06936956
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Giresun University
Cancer-related Problem/Condition, Neurotoxicity
Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
RATIONALE: Electrical stimulation pain therapy may help relieve chronic pain and numbness caused by chemotherapy. PURPOSE: This pilot trial studies electrical stimulation pain therapy in treating chronic pain and numbness caused…
- Conditions
- Cancer-related Problem/Condition, Neurotoxicity, Pain, Peripheral Neuropathy
- Trial name
- NCT01196442
- Testing
- electrical stimulation pain therapy, questionnaire administration
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Virginia Commonwealth University
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