Clinical trials: Peripheral Pulmonary Lesion, active
Lung Cancer (NSCLC)
Cryobiopsy Vs. Forceps Biopsy for Peripheral Pulmonary Lesions
This multicenter clinical trial evaluates the diagnostic yields of cryobiopsy and forceps biopsy for peripheral lung nodules. In the cryobiopsy group, cryobiopsy is the primary method, supplemented by forceps biopsy.
- Trial name
- NCT06752395
- Testing
- Transbronchial lung biopsy with radial probe endobronchial ultrasound (Cryobiopsy centered), Transbronchial lung biopsy with radial probe endobronchial ultrasound (Forceps biopsy centered)
- Where
- 3 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Pusan National University Hospital
Peripheral Pulmonary Lesions (PPLs), Pulmonary Nodules
Comparative Study of Rotational Cryobiopsy Needle and Automated Biopsy Needle in Transthoracic Biopsy Diagnosing Peripheral Pulmonary Lesions
This study aims to systematically compare the diagnostic efficacy, specimen quality, and complication rates of the cryobiopsy needle technique（CassiII rotational core biopsy） versus the automated biopsy technique in the biopsy of…
- Trial name
- NCT07772479
- Testing
- CassiII rotational core biopsy, Automated biopsy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Cancer
Prospective Cohort of Diagnostic Bronchoscopy for Peripheral Lung Lesions
The primary objective is To evaluate the usefulness and safety of advanced guided bronchoscopy for histological diagnosis of peripheral pulmonary lesions.
- Trial name
- NCT05804786
- Testing
- Guided bronchoscopy
- Where
- 11 sites in South Korea
- Volunteers
- 1,240 people
- Sponsor
- Seoul National University Bundang Hospital
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules
Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules
The goal of this clinical trial is to learn whether intraoperative longitude-latitude-depth three-dimensional localization (LLD localization) is non-inferior to preoperative CT-guided percutaneous lung puncture localization for…
- Conditions
- Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules, Pulmonary Nodules
- Trial name
- NCT07675889
- Testing
- Longitude-Latitude-Depth Localization, CT-Guided Percutaneous Lung Puncture Localization
- Where
- 4 sites in China
- Volunteers
- 274 people
- Sponsor
- Qilu Hospital of Shandong University
Diagnosis
The Study of ENB With Ultra-thin Cryobiopsy in the Diagnosis of Peripheral Pulmonary Nodules
To investigate the safety and efficacy of ultrafine cryoprobe biopsy by electromagnetic navigation bronchoscopy compared with biopsy forceps in the diagnosis of peripheral pulmonary nodules in a national multicenter randomized…
- Trial name
- NCT07326072
- Testing
- Cryobiopsy, Forceps biopsy
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Beijing Chao Yang Hospital
Lung; Node
Robotic Systems Evaluation for Peripheral Pulmonary Lesions (RISE Trial)
This is an investigator-initiated cluster randomized control trial. The primary objective is to compare the diagnostic yield of two Food and Drug Administration (FDA) cleared national robotic assisted bronchoscopy platforms - the…
- Trial name
- NCT07735611
- Testing
- RAB via the Monarch platform, RAB via the ION platform
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- Case Comprehensive Cancer Center
Lung Neoplasms, Diagnosis
Benefit of Cone-beam CT and Robotic-Assisted Bronchoscopy During Bronchoscopy
This randomized controlled trial evaluates the integration of cone-beam computed tomography (CBCT) and robotic-assisted bronchoscopy (RAB) for diagnosing pulmonary lesions, hypothesizing improved diagnostic yield compared to…
- Conditions
- Lung Neoplasms, Diagnosis, Lung Cancer
- Trial name
- NCT06489678
- Testing
- Robotic Assisted Bronchoscopy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Lung Cancer, Nodes, Lung
Confirmation of Accuracy of the Tool-in-lesion Technology (TiLT) of the Galaxy System With Integrated TOMO Technology
This study will evaluate the feasibility of performing robotic navigation of peripheral airways in human subjects for the purpose of biopsying peripheral lung lesions.
- Trial name
- TiLT (NCT06056128)
- Testing
- Robotic assisted bronchoscopy
- Where
- Hong Kong
- Volunteers
- 25 people
- Sponsor
- Noah Medical
Peripheral Pulmonary Lesions (PPLs)
CLE vs. ROSE for Ex Vivo Lung Biopsy Assessment
The goal of this observational study is to evaluate the diagnostic efficacy of Confocal Laser Endomicroscopy (CLE) compared to Rapid On-Site Evaluation (ROSE) for ex vivo lung biopsy specimens obtained via bronchoscopy.
- Trial name
- NCT07725510
- Testing
- Ex Vivo Confocal Laser Endomicroscopy (CLE) Imaging and Interpretation, Rapid On-Site Evaluation (ROSE) Imaging and Interpretation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Pulmonary Nodules
The SEQUENCE Trial
This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd…
- Trial name
- SEQUENCE (NCT06676956)
- Testing
- Linear EBUS first, Robotic-assisted bronchoscopy first
- Where
- 5 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Peripheral Pulmonary Lesions
Clinical Utility of Needle-Based Confocal Laser Endomicroscopy for Peripheral Pulmonary Lesions
This prospective, multicenter diagnostic accuracy study will evaluate the clinical utility of needle-based confocal laser endomicroscopy (nCLE) for differentiating malignant from benign peripheral pulmonary lesions (PPLs).
- Trial name
- NCT07827326
- Testing
- Confocal Laser Endomicroscopy
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Lung Ultrasound, Lung Cancer (Diagnosis)
3D-US Construct on Volumetric Assessment of Lung Disease & Clinical Application
The goal of this observational study is to establish the three-dimensional construct of lung lesion via ultrasound in patients with peripheral lung lesions or any superficial lesion in thoracic fields.
- Conditions
- Lung Ultrasound, Lung Cancer (Diagnosis), Peripheral Lung Lesions, Ultrasound Assessment
- Trial name
- NCT07574255
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Peripheral Pulmonary Lesion, Lung Nodule, Solitary
Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT Using Integrated Intraprocedural Imaging
RELIANT 2 is a pragmatic randomized controlled trial. The goal of this study is to compare the diagnostic yield of robotic assisted bronchoscopy with integrated cone beam computed tomography to that of electromagnetic navigation…
- Trial name
- RELIANT 2 (NCT06654271)
- Testing
- Robotic assisted bronchoscopy (RAB), Electromagnetic navigation bronchoscopy (ENB)
- Where
- 4 sites in United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Lung Nodule, Solitary, Lung Nodule
Iriscope for the Diagnosis of Peripheral Pulmonary Lesions: a Multicentre Randomised Controlled Trial
A pulmonary nodule is a small mass detected in your lungs during a scan. When a nodule is suspicious, we need to determine its nature (benign or malignant). To do this, a bronchoscopy is performed.
- Conditions
- Lung Nodule, Solitary, Lung Nodule, Lung Cancer (Diagnosis)
- Trial name
- NCT07798362
- Testing
- Use of Iriscope via guide sheath to guide biopsies, Bronchoscopy
- Volunteers
- 140 people
- Sponsor
- Erasme University Hospital
Peripheral Lung Lesions
Comparison of the Diagnostic Accuracy: US-guided Percutaneous Lung Biopsies vs CT-guided in Peripheral Lung Lesions
A non-sponsored prospective randomized single-blind national multicenter interventional study which aims to compare the diagnostic accuracy between US-guided percutaneous lung needle biopsies and CT-guided in peripheral lung…
- Trial name
- SULTAN (NCT06412289)
- Testing
- US-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY, CT-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY
- Where
- 2 sites in Italy
- Volunteers
- 236 people
- Sponsor
- University Hospital of Ferrara
Peripheral Pulmonary Lesions (PPLs), Lung Nodules
Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions
This is an investigator-initiated, multicenter, non inferiority, cluster randomized controlled trial. The primary objective is to compare the diagnostic yield of the electromagnetic robotic assisted bronchoscopy with digital…
- Trial name
- SERENE (NCT07411989)
- Testing
- Bronchoscopy for peripheral pulmonary lesion biopsy
- Where
- 2 sites in United States
- Volunteers
- 346 people
- Sponsor
- The Cleveland Clinic
Peripheral Pulmonary Lesions (PPLs)
Clinical Validation Study on the Imaging Efficacy of Mobile 4D CBCT Technology for Peripheral Pulmonary Lesions
The purpose of this study is to evaluate the clinical value of mobile 4D CBCT technology in the diagnosis and treatment of peripheral pulmonary lesions and to validate its intraoperative dynamic three-dimensional CT imaging…
- Trial name
- NCT07149597
- Testing
- Mobile CBCT Three-Dimensional Scanning
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Peripheral Lung Lesions
Diagnosing peRipheral Lung Lesions With CRYO Biopsies
Lung cancer is the leading course of cancer related deaths world-wide. Lung cancer screening will increase the number of small lung lesion in need of biopsy to confirm the diagnosis.
- Trial name
- DR CRYO (NCT06844344)
- Testing
- forceps biopsies, Cryo biosies
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Peripheral Pulmonary Lesion
Diagnostic Value of Confocal Laser Endomicroscopy (CelTouch) for Peripheral Lung Lesions
This study uses CelTouch to explore patients with lung lesions scheduled for lung biopsy. By comparing with preclinical CLE images and pathological images, CLE diagnostic criteria for benign and malignant lung lesions under the…
- Trial name
- NCT07004946
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Guangzhou Medical University