Clinical trials: Peripheral Sensitization
Diabetes Mellitus (DM)
Central Sensitization in Painful and Painless Diabetic Peripheral Neuropathy
This research is structured as a cross-sectional observational study. The primary objective is to compare central sensitization across painful and painless phenotypes of diabetic peripheral neuropathy.
- Trial name
- NCT07316322
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Inonu University
Low Back Pain, Recurrent, Neuropathic Pain
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting
The investigators will select two study groups from a population of patients with severe chronic low back pain (CLBP) of facet joint (FJ) origin already treated with conventional radiofrequency ablation (CRFA) of the medial…
- Conditions
- Low Back Pain, Recurrent, Neuropathic Pain, Facet Joint Pain, Central Sensitisation
- Trial name
- NCT04542798
- Testing
- Radiofrequency COSMAN
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario de Valencia
Sensitisation, Highly Sensitised Dialysis Patients
The Safety/Efficacy Of Daratumumab With Belatacept In Highly HLA-Sensitized Patients Awaiting Kidney Transplantation
While the number of kidney transplants is increasing worldwide every year, there is a clear imbalance between the high number of patients in the waiting list and those receiving a transplant and importantly, among waitlist…
- Trial name
- COMBAT (NCT05145296)
- Testing
- Each patient will undergo in the first step of the study belatacept treatment and in the second apheresis and daratumumab
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Grenoble
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Pelvic Pain, Vulvodynia
Psychosocial Factors and Central Sensitization in Chronic Pelvic Pain
The purpose of this study is to determine if the psychosocial factors in women with chronic pelvic pain are predisposing, precipitant or maintenance factors, and relate these factors with central sensitization and dysfunctional…
- Conditions
- Pelvic Pain, Vulvodynia, Pudendal Neuropathy
- Trial name
- NCT02856334
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Lumbar Radiculopathy, Central Sensitisation
Identifying Pain Generators and Potentiators of Residual Complaints Following Lumbar Discectomy
Lumbar discectomy (i.e. surgically removing a hernia) is frequently performed in Belgium to treat lumbar radiculopathy. Every year >12,000 interventions are performed with variable long-term results.
- Trial name
- DISC-PAIN (NCT05022251)
- Testing
- Lumbar discectomy
- Where
- Belgium
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Ghent
Central Nervous System Sensitization, Peripheral Nervous System Disorders
Effects of Soft Tissue Treatment vs Mechanisms Explanation to Treat Delayed Onset Muscles Soreness Among Sport Climbers
The aim of the present research is to define the effects of short manual treatment of soft tissues compared to mechanisms explaining in Delayed Onset Muscle Soreness (DOMS) among sport climbers and to address the mechanisms of…
- Conditions
- Central Nervous System Sensitization, Peripheral Nervous System Disorders, Muscle Soreness, Muscle Strength
- Trial name
- NCT04255212
- Testing
- Soft tissue treatment, Mechaninsms explanation, Control Group
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Achilles Tendon Pain
Achilles Pain Block
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT).
- Trial name
- APB (NCT03316378)
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ruth Chimenti
Fibromyalgia, Primary, Fibromyalgia
Pain Phenotypes in Patients With Fibromyalgia Syndrome
Fibromyalgia Syndrome (FMS); is a complex syndrome characterized by many symptoms such as chronic widespread pain, fatigue and sleep disorders, cognitive dysfunctions and psychiatric disorders.
- Conditions
- Fibromyalgia, Primary, Fibromyalgia, Chronic Pain Syndrome, Pain, Neuropathic
- Trial name
- NCT05941780
- Testing
- Pain classification method
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Kutahya Health Sciences University
Carpal Tunnel Syndrome, Central Sensitisation
Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome
This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms.
- Conditions
- Carpal Tunnel Syndrome, Central Sensitisation, Pain, Radiating
- Trial name
- NCT07114913
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Ankylosing Spondylitis, Peripheral Neuropathies
Assessment of Peripheral Neuropathy in Ankylosing Spondylitis
investigators hypothesized that peripheral neuropathy in ankylosing spondylitis is associated with higher disease activity, greater central sensitization, worse functional impairment, and poorer quality of life.
- Trial name
- NCT07641920
- Testing
- Nerve conduction study
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Complex Regional Pain Syndrome (CRPS)
Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome
Transcranial direct current stimulation (tDCS) is a non-invasive therapy increasingly used in facilities treating patients with chronic pain.
- Trial name
- ALGOSTIM (NCT07361692)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Polyclinique de l'Europe
Chronic Plantar Fasciitis, Control Group
Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients.
- Trial name
- NCT06348017
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Yozgat City Hospital
Chronic Shoulder Pain
Influence of Biopsychosocial Factors and Central Sensitization in Predicting the Recovery of Chronic Shoulder Pain
Background: Shoulder pain is the third most common musculoskeletal condition presenting to physicians or physiotherapists ) in primary healthcare after low back and neck pain being a significant cause of morbidity and functional…
- Trial name
- NCT02738372
- Testing
- Diagnosis/Prognosis
- Volunteers
- 90 people
- Sponsor
- University of Malaga
Pain
Bupivacaine Versus Lidocaine on Inflammatory Regulation
This study is testing a local anesthetic (numbing medicine) to suppress pain. Bupivacaine and lidocaine are FDA approved local anesthetics that may decrease pain following surgery.
- Trial name
- NCT01060774
- Testing
- Lidocaine, Bupivacaine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Maryland
Central Sensitisation
Investigation of the Relationship Between Central Sensitization and Neuropathic Pain in Lumbar Disc Herniation
Central sensitization (CS) is as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with in many musculoskeletal diseases with chronic pain has been demonstrated in several…
- Trial name
- NCT06269068
- Testing
- Central sensitization inventory, Short form-36, Oswestry Low Back Pain Disability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Marmara University
Osteoarthritis, Knee
Effects of Central Sensitization on Response to Conventional Physical Therapy in Patients With Knee Osteoarthritis
The aim of this study was to investigate the relationship between central sensitization (CS) and poor response to conventional physical therapy in patients with knee osteoarthritis (OA) by evaluating clinical parameters of pain…
- Trial name
- NCT05518097
- Testing
- Conventional physical therapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Neuropathic Pain
The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty
It has been well known that central sensitization (CS) is a risk factor for inferior outcomes following total knee arthroplasty (TKA).
- Trial name
- NCT05581836
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- The Catholic University of Korea
Raynaud Phenomenon, Raynaud Disease
Effectiveness of Electric Stimulation Therapy in Raynaud's Phenomenon
The purpose of this study is to analyze the effects of an intervention with galvanic electrical current on the number of attacks , temperature, pain, peripheral blow flow and upper limb functionality in patients with Raynaud's…
- Trial name
- NCT03699436
- Testing
- Electrotherapy with Galvanic Current, Control without Electric Stimulation Therapy
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Granada
Chronic Plaque-type Psoriasis
Serum Substance P, Neuropathic Pain, and Central Sensitization Across Treatment Groups in Chronic Plaque Psoriasis
The goal of this observational study is to better understand whether blood levels of Substance P are related to pain, itching, altered pain sensations, central sensitization, psoriasis severity, and quality of life in adults with…
- Trial name
- NCT07844772
- Testing
- IL-17 Inhibitor Therapy, Conventional Systemic Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Training and Research Hospital