Clinical trials: Peripheral Sensitization
Chronic Pain, Nociceptive Pain
Central Sensitisation in Nociceptive and Neuropathic Pain
This study aims to investigate differences in central sensitization among patients with chronic nociceptive pain, neuropathic pain, and mixed pain conditions.
- Conditions
- Chronic Pain, Nociceptive Pain, Neuropathic Pain, Mixed Pain (Nociceptive and Neuropathic)
- Trial name
- ALGOS (NCT07321080)
- Testing
- Neuropsychological assessment, Laser evoked potentials
- Where
- Italy
- Volunteers
- 185 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Chronic Pancreatitis
Intraductal Liposomal Bupivacaine for Chronic Pancreatitis
The major clinical features of chronic pancreatitis include glandular (exocrine and endocrine) failure and pain. Pain has remained a major clinical challenge and is present in up to 90% of patients and is the primary cause of…
- Trial name
- NCT04611958
- Testing
- ERCP with Bupivacaine infusion
- Where
- United States
- Sponsor
- Johns Hopkins University
Work-related Illness
Central and Peripheral Sensitization, Pain Mediators in Thumb Pain Among Physiotherapists
The work-related thumb pain is a common problem among physiotherapists which deal with this experience at least once in their life.
- Trial name
- NCT05345496
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Pain, Central Sensitisation
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian…
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- BSPP (NCT07109843)
- Testing
- Boswellia serrata extract
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Carpal Tunnel Syndrome
Mechanisms of Neural Mobilization in the Treatment of Chronic Pain
The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in…
- Trial name
- NCT00929123
- Testing
- neural mobilization, healthy controls
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Neuropathic Pain, Nociplastic Pain
Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches
The primary objective of this study will be to demonstrate a change in pain sensitization parameters before and after the application of the high-concentration capsaicin patch.
- Trial name
- CAPSASENS (NCT07660510)
- Testing
- Quantitative Sensory Testing and questionnaires
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Fibromyalgia
Clinical Effects of Radiofrequency in Fibromyalgia
The aim of this study is to analyze the effects of a single-session of Radiofrequency in patients with Fibromyalgia in comparison to a placebo group.
- Trial name
- NCT05641740
- Testing
- Single-session of Radiofrequency
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Thoracic Outlet Syndrome
Motivational Interviewing in Thoracic Outlet Syndrome
The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS).
- Trial name
- NCT07668206
- Testing
- Motivational Interviewing, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Fibromyalgia
Generalized Hypersensitivity in Patients With Fibromyalgia Syndrome
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder with unknown causes. Our previous studies showed abnormal sensations of second pain (wind-up), indicating central hypersensitivity as an important mechanism of FM.
- Trial name
- NCT04415866
- Testing
- Paced Auditory Serial Addition task (PASAT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Complex Regional Pain Syndrome Type I
Pain in Complex Regional Pain Syndrome
CRPS is a complex pain condition that usually develops in response to trauma and immobilization which is very painful and debilitating.
- Trial name
- NCT04667364
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cervicogenic Headache, Central Sensitization
Central Sensitization and Neuropathic Pain in Cervicogenic Headache
Cervicogenic headache is a type of secondary headache that originates from the structures of the neck and can spread toward the head and facial regions.
- Conditions
- Cervicogenic Headache, Central Sensitization, Neuropathic Pain
- Trial name
- NCT07292181
- Testing
- Clinical assessment with standardized questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Pain
Remote Ischemic Preconditioning Mechanism Study
This research is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury.
- Trial name
- NCT01541436
- Testing
- Remote Ischemic Preconditioning, Capsaicin, UV-B
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Rotator Cuff Tears, Central Sensitisation
Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair.
- Conditions
- Rotator Cuff Tears, Central Sensitisation, Neuropathic Pain
- Trial name
- NCT06367998
- Testing
- Pregabalin
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Carpal Tunnel Syndrome
Nociceptive Gain Processing After Physical Therapy in Carpal Tunnel Syndrome
This randomized clinical trial will investigate changes in pain intensity and nociceptive gain processing after the application of either physical therapy or surgery in women with carpal tunnel syndrome (CTS).
- Trial name
- NCT02219919
- Testing
- Surgical Group, Physical Therapy Group
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Rey Juan Carlos
Radiculopathy
Effect of Neural Mobilization on Lumbosacral Radiculopathy Patients With Peripheral Sensitization
The primary purpose of this study was to investigate the effects of slider and tensioner techniques on pain, hip and knee ROM in lumbosacral radiculopathy patients with peripheral sensitization.
- Trial name
- NCT03621878
- Testing
- Neural mobilization exercises -Tensioner technique, Neural mobilization exercises -Slider technique, Transcutaneous Electrical Nerve Stimulation (TENS)
- Volunteers
- 51 people
- Sponsor
- Mohammed Al-Ghamdi
Pain, Chronic, Pain, Acute
The Effect of Palmitylethanolamide on Central and Peripheral Sensitization After Heat-induced Hyperalgesia
This planned study is based on a randomized, placebo-controlled cross-over design. Palmityhlethanolamide (PEA) is an endogenous fatty acid amide from the group of N-Acetylethanolamides, which analgesic, anti-inflammatory and…
- Conditions
- Pain, Chronic, Pain, Acute, Central Sensitisation, Neuroinflammatory Response
- Trial name
- NCT04662827
- Testing
- Palmithylethanolamid
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Central Sensitisation, Carpal Tunnel Syndrome
Investigation of the Relationship Between Pain Sensitization and Diagnostic Parameters in Carpal Tunnel Syndrome
The aim of this observational, cross-sectional study is to investigate the relationship between pain sensitization and ultrasonographic and nerve conduction studies in patients diagnosed with carpal tunnel syndrome (CTS).
- Trial name
- NCT06043141
- Testing
- Nerve ultrasound, Nerve conduction studies, Pressure pain threshold
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Neuropathic Pain, Central Sensitization
Neuropathic Characteristics of Subacromial Pain Syndrome
This single-center observational study aims to investigate neuropathic pain descriptors and their relationship with central sensitization in patients diagnosed with subacromial pain syndrome (SAPS) who have had shoulder pain for…
- Conditions
- Neuropathic Pain, Central Sensitization, Subacromial Pain Syndrome
- Trial name
- NCT07057128
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Izmir City Hospital