Clinical trials: Peripheral Vascular Disease (PVD)
Peripheral Arterial Disease, Claudication, Intermittent
Arterial Imaging of Inflammation and Resolution After Endovascular Surgery
This study evaluates the local inflammatory and resolution response of patients undergoing peripheral vascular intervention like an angioplasty of the superficial femoral artery (SFA) or popliteal artery, or stenting of the iliac…
- Conditions
- Peripheral Arterial Disease, Claudication, Intermittent, Claudication, PAD
- Trial name
- AIIRES (NCT03590769)
- Testing
- 18F-FDG
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Peripheral Artery Disease
AcoArt Ⅱ/ BTK China: Drug-eluting Balloon for Below-The-Knee Angioplasty Evaluation in China
The purpose of this study is to determine whether DEB is more effective than common PTA balloon using under in long-term vessel patency and inhibiting restenosis in the infrapopliteal artery.
- Trial name
- NCT02137577
- Testing
- DEB catheter, common PTA balloon catheter
- Where
- 11 sites in China
- Volunteers
- 120 people
- Sponsor
- Acotec Scientific Co., Ltd
Intermittent Claudication
Invasive Revascularization or Not in Intermittent Claudication
Peripheral arterial disease (PAD) often causes exertion pain in the legs, intermittent claudication (CI) affecting> 10% of individuals> 65 years.
- Trial name
- IRONIC (NCT01219842)
- Testing
- INVASIVE (INV) treatment, Best medical treatment (BMT)
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Sahlgrenska University Hospital
Peripheral Arterial Disease
POWER: Pulse Intravascular Lithotripsy (Pulse IVL) to Open Vessels With Calcific Walls and Enhance Vascular Compliance and Remodeling
The POWER-PAD-1 Study is a first-in-human evaluation of the safety and performance of the Pulse Peripheral Intravascular Lithotripsy (IVL) Balloon Catheter to enroll up to twenty (20) subjects.
- Trial name
- POWER-PAD-1 (NCT05192473)
- Testing
- Pulse Intravascular Lithotripsy System
- Where
- 3 sites in Australia, Dominican Republic and 1 more
- Volunteers
- 9 people
- Sponsor
- Amplitude Vascular Systems, Inc.
Peripheral Arterial Disease, Lower Extremity Arterial Disease
Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries
This study will test whether using ultrasound imaging within blood vessels during minimally invasive treatment of leg arteries in patients with peripheral artery disease leads to better clinical outcomes.
- Trial name
- INVIGOR (NCT07353905)
- Testing
- Intravascular Ultrasound (IVUS), Angiographic-guided Intervention
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- Baylor Research Institute
Cardiovascular Diseases, Acute MI
Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population
The main objective of this project is to evaluate the genomic information previously associated with cardiovascular diseases (CVD) and its importance as an independent risk predictor (expressed in Odds Ratio) when adjusted for…
- Conditions
- Cardiovascular Diseases, Acute MI, Stroke, Peripheral Arterial Disease
- Trial name
- CV-GENES (NCT05515653)
- Testing
- Exposure to genetics (polygenic)
- Where
- 41 sites in Brazil
- Volunteers
- 3,974 people, healthy volunteers welcome
- Sponsor
- Hospital Alemão Oswaldo Cruz
Post Thrombotic Syndrome, Venous Thromboses
Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome
Post-thrombotic syndrome (PTS) is the most frequently observed chronic complication of deep vein thrombosis (DVT), with an estimated cumulative incidence of 20-50%.
- Conditions
- Post Thrombotic Syndrome, Venous Thromboses, Claudication, Intermittent
- Trial name
- ETERecaVSPT (NCT05794932)
- Testing
- Stress test
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Montpellier
Peripheral Arterial Disease
Stimulation TcPO2 Test in the PAD Diagnosis in Diabetic Foot
All diagnostic procedures of peripheral arterial disease (PAD) in the diabetic foot (DF) are limited due to diabetes mellitus and its late complications.
- Trial name
- stimTcPO2 (NCT04404699)
- Testing
- Stimulation TcPO2 test
- Where
- Czechia
- Volunteers
- 79 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions, Moderate or Severe Claudication (Rutherford Category 2 or 3)
Korean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease (K-ELUVIA Registry)
Prospective, multi-center single-arm observational study A total of 100 subjects with femoropopliteal artery disease who meet all inclusion and exclusion criteria will be included.
- Conditions
- Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions, Moderate or Severe Claudication (Rutherford Category 2 or 3), Critical Limb Ischemia (Rutherford Category 4 or 5)
- Trial name
- NCT03505931
- Testing
- Implantation of Eluvia stent
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Peripheral Arterial Disease
Belgian Study to Assess the Efficacy and Safety of the RESTORER Iliac Stent for Treatment of Aorto-iliac Lesions.
The BARISTA study tests the safety and efficacy of the Restorer stent from the company iVascular. This stent is a medical device that is already approved for use in Europe, to treat stenotic (narrowed) iliac arteries.
- Trial name
- BARISTA (NCT05293002)
- Testing
- Restorer Iliac Stent System
- Where
- 14 sites in Belgium
- Volunteers
- 131 people
- Sponsor
- ID3 Medical
Peripheral Arterial Disease
Safety and Effectiveness of Jetstream Atherectomy System (J-SUPREME)
The purpose of this study is to evaluate the safety and effectiveness of the Jetstream Atherectomy System for the treatment of Japanese patients with symptomatic occlusive atherosclerotic lesions in native superficial femoral…
- Trial name
- NCT02733653
- Testing
- Jetstream Atherectomy System
- Where
- 10 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Deep Vein Thrombosis
Catheter-Directed Venous Thrombolysis in Acute Iliofemoral Vein Thrombosis
Deep vein thrombosis (DVT) is a severe disease, and conventional treatment with low molecular weight heparin (LMWH) and warfarin is associated with some degree of long-term sequelae, i.e. post-thrombotic syndrome (PTS).
- Trial name
- CaVenT (NCT00251771)
- Testing
- catheter-directed venous thrombolysis
- Where
- Norway
- Volunteers
- 209 people
- Sponsor
- Oslo University Hospital
Peripheral Artery Disease
Ankle-foot Orthoses for Peripheral Artery Disease
The primary aim of this study is to investigate the effect of an ankle foot orthoses (AFO) on the primary outcome of peak walking time (PWT) in patients with peripheral artery disease (PAD).
- Trial name
- NCT02280200
- Testing
- AFO to improve outcomes
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Minnesota
Peripheral Artery Disease
Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis
This study will determine whether an ankle foot orthosis (AFO) improves walking performance in participants with PAD from its first use.
- Trial name
- NCT02902211
- Testing
- Ankle foot orthosis, Control/standard of care
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Arterial Disease
Debulking Atherectomy Versus Stent Angioplasty for Limb Ischaemia of Diabetic Lower Limb Atherosclerosis-occlusive Disease.
In order to assessment the safety and efficacy of debulking atherectomy versus stent angioplasty for limb ischaemia of diabetic lower limb atherosclerosis-occlusive disease, we intend to conduct a prospective, multicenter…
- Trial name
- NCT05670171
- Testing
- Debulking Atherectomy, Stent Angioplasty
- Where
- 10 sites in China
- Volunteers
- 244 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease, Paclitaxel Adverse Reaction
Safety Assessment of Femoropopliteal Endovascular Treatment With PAclitaxel-coated Devices (SAFE-PAD Study)
The SAFE-PAD Study aims to evaluate the long-term safety of paclitaxel-coated devices compared with non-paclitaxel-coated devices for femoropopliteal artery revascularization among a broad, real-world population of patients with…
- Conditions
- Peripheral Arterial Disease, Paclitaxel Adverse Reaction, Safety Issues
- Trial name
- SAFE-PAD (NCT04496544)
- Testing
- Retrospective data collection
- Where
- United States
- Volunteers
- 168,553 people
- Sponsor
- Beth Israel Deaconess Medical Center
Peripheral Arterial Disease, Aortoiliac Occlusive Disease
Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study
Peripheral arterial disease involving the iliac arteries is a common manifestation of systemic atherosclerosis and a major cause of lifestyle-limiting claudication and chronic limb-threatening ischemia.
- Conditions
- Peripheral Arterial Disease, Aortoiliac Occlusive Disease, Chronic Limb-Threatening Ischemia, Intermittent Claudication
- Trial name
- PREMISE-ILIAC (NCT07672249)
- Testing
- Iliac stenting
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Iliac Artery Disease
Korean Multicenter Registry of EPIC Stent for Iliac Artery Disease: (K-EPIC Registry)
Prospective, single-arm, multi-center registry study A total of 150 subjects with iliac artery disease who meet all inclusion and exclusion criteria will be included.
- Trial name
- NCT02698358
- Testing
- Epic stent (Boston Scientific)
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Yonsei University
Critical Limb Ischemia
Autologous Stem Cells for the Treatment of No Option Critical Limb Ischemia
The trial is a phase 1b, open label, uncontrolled, non-randomized dose-escalation study of autologous bone marrow-derived MSCs. Following informed consent, patients who meet the criteria will be screened and enrolled.
- Trial name
- NCT03455335
- Testing
- 20 million hMSCs, 40 million hMSCs, 80 million hMSCs
- Where
- Ireland
- Volunteers
- 12 people
- Sponsor
- National University of Ireland, Galway, Ireland
Peripheral Arterial Diseases
EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study
The purpose of this study is to collect acute confirmatory data to evaluate technical success and acute safety of the EverFlex™ self-expanding peripheral stent with Entrust™ delivery system.
- Trial name
- NCT02066740
- Testing
- EverFlex™ stent with Entrust™ delivery system
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Medtronic Endovascular
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