Clinical trials: Periprosthetic Joint Infection
Infection, Surgical Site Infection
Changing of Dressing for Periprosthetic Joint Infection in Total Knee Arthroplasty
The primary aim of the study is to compare two methods for a relationship with total knee infection: regular changing of dressings and not changing dressings.
- Conditions
- Infection, Surgical Site Infection, Prosthetic Infection, Wound Infection
- Trial name
- NCT04346875
- Testing
- Regularly changing of dressing, No application
- Volunteers
- 842 people
- Sponsor
- Bezmialem Vakif University
Joint Infection
Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Occurring After Total Knee Arthroplasty (TKA)
The purpose of this study is to learn about the safety and effects of PLG0206 for treating periprosthetic joint infections (PJI) in conjunction with the DAIR (debridement, antibiotics and implant retention) surgical procedure for…
- Trial name
- NCT05137314
- Testing
- PLG0206
- Where
- 12 sites in United States
- Volunteers
- 14 people
- Sponsor
- Peptilogics
Arthropathy of Hip, Arthropathy of Knee
Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
- Trial name
- NCT03365323
- Testing
- Periprosthetic Joint Infection, Non-Periprosthetic Joint Infection
- Volunteers
- 160 people
- Sponsor
- Peking University People's Hospital
Periprosthetic Joint Infection
Use of Phage Therapy for Treatment of a Periprosthetic Joint Infection
The goal of this clinical trial is to learn about the safety, tolerability and activity or efficacy of systemic intravenous and intraarticular administration of a mono-bacteriophage (phage) peparation in a patient with…
- Trial name
- BPhage (NCT06827041)
- Testing
- Phage (Cytophage Technologies)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Ottawa Hospital Research Institute
Peri-Prosthetic Joint Infection
IP-coated Revision Hip Implants
The primary aim of the clinical investigation is to demonstrate the efficacy of a silver-based antimicrobial coating on hip implants in the reduction of periprosthetic infections in revision hip arthroplasty due to periprosthetic…
- Trial name
- HIPrevision (NCT06737809)
- Testing
- IP Plasmafit® Revision cup (and stem) system
- Where
- 2 sites in Germany, Poland
- Volunteers
- 268 people
- Sponsor
- Aesculap AG
Periprosthetic Joint Infections
Laser Disinfection in Periprosthetic Joint Infection
The eradication of biofilms from infected implants is still an unsolved challenge. The high-energy light beam of an Er:YAG laser causes rapid heating and explosive ablation of tissue.
- Trial name
- NCT06440564
- Testing
- Er:YAG Laser irradiation
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Periprosthetic Joint Infection
Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid
To demonstrate the tests' performance when compared to the detection of PJI using the Musculoskeletal Infection Society (MSIS) criteria-based definition of PJI for diagnosing PJI.1 This criteria-based definition of PJI places…
- Trial name
- NCT02868736
- Testing
- Synovasure PJI Lateral Flow test and Synovasure PJI ELISA Test
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- CD Diagnostics
Surgical Site Infection
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.
- Trial name
- NCT02734134
- Testing
- One-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Infection of Total Knee Joint Prosthesis
Comparison of Two Different Techniques of Synovial Biopsy and Resistances of Cutaneous Smears in Suspected PPI
The purpose of this study is to determine whether an undirected synovial biopsy technique has the same accuracy in detecting periprosthetic joint infection in the knee as an arthroscopic assisted directed synovial biopsy…
- Trial name
- COSPI (NCT02594930)
- Testing
- synovial biopsy of total knee arthroplasty
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Periprosthetic Joint Infection
Intraoperative Microbial Contamination
This is a randomized, controlled study which aims to show whether iodine impregnated incisional foil (IobanTM) has a place in the prevention of prosthetic joint infection (PJI).
- Trial name
- ICON (NCT03139539)
- Testing
- Ioban
- Where
- 3 sites in Denmark
- Volunteers
- 1,661 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Infections Joint Prosthetic, Overweight or Obesity
Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk…
- Conditions
- Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA
- Trial name
- NCT04297592
- Testing
- Cephalexin, Doxycycline, Cefadroxil
- Where
- 2 sites in United States
- Volunteers
- 4,618 people
- Sponsor
- Mayo Clinic
PJI
Infection Consortium Study#1
In this study, the Sponsor wants to evaluate the performance and accuracy of the PJI Panel compared to the currently used multiple-criterion scoring systems for the diagnosis of PJI.
- Trial name
- NCT06153446
- Testing
- Synovasure® Comprehensive Infection Panel
- Where
- United States
- Volunteers
- 810 people
- Sponsor
- Zimmer Biomet
Periprosthetic Joint Infection, Septic Arthritis
Arthrocentesis Study
The purpose of this study is to analyze pre- and intra-operative joint aspirates of native joints and joints with suspicion of periprosthetic joint infection (PJI) of the hip, knee and shoulder acquired in clinical routine.
- Trial name
- NCT02530229
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Charite University, Berlin, Germany
Periprosthetic Joint Infection (PJI)
Efficacy of Serum ESR, CRP, Synovial Leucocyte Esterase Dipstick Test in The Diagnosis of Chronic Infection in Total Joint Arthroplasty
aim of this study was to determine accuracy of using leucocyte esterase (LE),Erythroscyte sedimentation rates (ESR) and C- Reactive protein (CRP) for diagnosing periprosthetic joint infections (PJI)
- Trial name
- ESR/CRP/LE pji (NCT07718386)
- Testing
- CRP, ESR, Leukocyte esterase dipstick test
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Prosthetic Joint Infection
Integrated Microfluidic Systems for Diagnosis of Periprosthetic Joint Infection
Diagnosing periprosthetic joint infection (PJI) remains a major clinical challenge. The diagnosis of PJI is based on a composition of clinical judgment, serologic test from peripheral blood, synovial fluid cytology and…
- Trial name
- NCT04056780
- Testing
- Sample collection study
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
SARS CoV 2 Infection
Using Vibroacoustic Therapy in a Patient With Co-infection and COVID-19
This article describes a case of successful treatment of a 59-year-old man with sepsis as a result of periprosthetic infection against the background of severe SARS-CoV-2-19, who was hospitalized for 59 days, 57 of which were in…
- Trial name
- NCT05188482
- Testing
- vibroacoustic therapy
- Where
- Kazakhstan
- Volunteers
- 1 people
- Sponsor
- Astana Medical University
Knee; Infection, Joint
Clinical Evaluation of Infection Control to Knee Periprosthetic Joint Infection (PJI) -United Cellbrick Knee Spacer
A novel polyethylene-based knee spacer (United Cellbrick Knee Spacer), for the purpose of infection control, was developed to enhance biomechanical safety and surgical convenience of articulating knee spacers.
- Trial name
- NCT06042062
- Testing
- Novel spacer, Spacer
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Joint Infection
Or v IV Antibiotics for Infection
Management of periprosthetic joint infection (PJI) commonly includes 6 weeks of intravenous (IV) antibiotics after surgical treatment. However, there is little evidence to suggest that oral (PO) therapy results in worse outcomes.
- Trial name
- NCT04723940
- Testing
- Bactrim, Cefadroxil, Doxycycline Hcl
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Periprosthetic Fracture Around Prosthetic Joint Implant
Investigating Periprosthetic Fracture Cultures in Arthroplasty
This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment…
- Trial name
- NCT06952738
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago