Clinical trials: Peroperative Complication
Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy
Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy
The purpose of this is study is to assess the efficacy of pre-operative intravitreal bevacizumab (IVB) (Genentech, South San Francisco CA) in improving visual acuity, reducing operative time, complications, intra-operative and…
- Trial name
- NCT01976923
- Testing
- Intravitreal bevacizumab, Small-gauge pars plana vitrectomy
- Where
- Saudi Arabia
- Volunteers
- 224 people
- Sponsor
- J. Fernando Arevalo, MD FACS
Blood Loss, Surgical
Prospective, Multicenter, Multidisciplinary, Controlled Clinical Investigation Evaluating the Safety and Efficacy of PerClot® Polysaccharide Hemostatic System
This is a prospective, multicenter, multidisciplinary, controlled clinical investigation evaluating the safety and efficacy of PerClot in achieving intraoperative hemostasis compared to a similar marketed hemostatic device.
- Trial name
- CLOT (NCT02359994)
- Testing
- PerClot Polysaccharide Hemostatic System, Arista AH
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Artivion Inc.
Intraoperative Bleeding
Lidocaine in ERAS for FESS
Functional endoscopic sinus surgery (FESS) is a commonly performed procedure. It is known that bleeding during FESS can affect directly to the visibility of safe landmarks and surgical outcomes.
- Trial name
- NCT03047070
- Testing
- Lidocaine, Normal saline
- Where
- 2 sites in Egypt
- Volunteers
- 43 people
- Sponsor
- Assiut University
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Liver Transplant; Complications, Surgical Injury
Magnetic Spiderman for Preparation of Liver Donation
Due to many vascular branches on the supra-hepatic vena cava (SHVC) and infra-hepatic vena cava (IHVC), in the whole procedures of preparation of liver donation, preparation of hepatic vena cava (HVC) is the most key and…
- Trial name
- MSPLD (NCT04182256)
- Testing
- MS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Intraoperative Awareness
Effect of Remifentanil on the Bispectral Index in Women Undergoing Caesarean Delivery Under General Anaesthesia
Patients undergoing caesarean delivery under inhalation anaesthesia are at a high risk of awareness, especially in the period before delivery.
- Trial name
- NCT03508102
- Testing
- remifentanil
- Volunteers
- 60 people
- Sponsor
- West China Second University Hospital
Anesthesia
Decision Support System for Anesthetists
The balanced anesthesia process contains three main parts: the control of hypnosis, analgesia, and neuromuscular blockade. For the induction phase, the anesthesiologist performs protocols based on prior planning specific to each…
- Trial name
- Serenity (NCT04079036)
- Where
- Brazil
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Blood Loss, Surgical
Safety and Immunogenicity Study of Recombinant Thrombin (rThrombin) in Pediatric Participants
The objective of this study is to assess the safety and immunogenicity of recombinant thrombin (rThrombin) administered as an aid to hemostasis during burn wound excision and skin grafting in pediatric patients, newborn through…
- Trial name
- NCT00859547
- Testing
- rThrombin, 1000 IU/mL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ZymoGenetics
Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery
Diagnostic Efficacy of CNN in Predicting Intraoperative Complications and Postoperative Outcomes in SMILE
To evaluate the diagnostic efficiency of the neural network in predicting complications of Small Incision Lenticule Extraction in a multi-center cross-sectional study.
- Conditions
- Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery, Intraoperative Complications, Postoperative Outcomes
- Trial name
- NCT06204926
- Testing
- AI diagnostic algorithm
- Where
- China
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Laparoscopic Technique no Switch to Open, Duration of Surgery
Clinical Trial Comparing Conventional and Robot-assisted(Da Vinci®)Laparoscopic Interventions for Hysterectomy
The aim of this study is to compare conventional with robot-assisted (Da Vinci®) laparoscopic hysterectomy regarding operating time peri-operative outcome and costs.
- Conditions
- Laparoscopic Technique no Switch to Open, Duration of Surgery, Intraoperative Complications, Postoperative Complications
- Trial name
- NCT00683293
- Testing
- Conventional Laparoscopic Hysterectomy, Robot-assisted (Da Vinci®) laparoscopic hysterectomy
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Aarau
Chronic Rhinosinusitis (CRS) with and Without Nasal Polyps
Correlation of Preoperative Indices (serum Vit D, Calcium, Phosphorus, FAR, PLR, SII) on Intraoperative Bleeding in CRS
The purpose of this observational study was to examine whether preoperative indicators correlate with intraoperative bleeding to facilitate control of intraoperative bleeding.
- Trial name
- NCT06737198
- Testing
- without interventios.
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Blood Loss, Surgical, Fluid Retention
Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement
Fluid intravascular replacement is usually performed with either balanced crystalloids or iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin).
- Trial name
- VASCALB (NCT05391607)
- Testing
- Hyperoncotic Albumin 20%, Isooncotic Albumin 5%, Ringer's Lactate Crystalloid Solutions (control group)
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intraoperative Complications, Respiratory Complication
Lower Inspiratory Oxygen Fraction for Preoxygenation
During the induction period of general anesthesia, surgical patients are inevitably experienced a short period of apnea for endotracheal intubation or other airway manipulation.
- Conditions
- Intraoperative Complications, Respiratory Complication, Oxygen Toxicity, Oxygen Deficiency
- Trial name
- NCT03665259
- Testing
- Pure oxygen group, Lower oxygen group
- Where
- Taiwan
- Volunteers
- 304 people
- Sponsor
- E-DA Hospital
Hypothermia; Anesthesia, Hyperthermia, Anesthesia Related
Inadvertent Hypothermia or Hyperthermia in Pediatric Radiotherapy Practices Under Anesthesia
In prospective, observational cohort study, changes in body temperature will be investigated before the procedure and during recovery in Radiotherapy patients aged 0-18 years who need sedation due to childhood malignancies.
- Conditions
- Hypothermia; Anesthesia, Hyperthermia, Anesthesia Related, Radiotherapy Side Effect, Childhood Cancer
- Trial name
- NCT05478850
- Testing
- radiotherapy under anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people
- Sponsor
- Ankara City Hospital Bilkent
Blood Loss, Surgical, Postpartum Hemorrhage
Ideal Time of Oxytocin Infusion During Cesarean Section
This study will evaluate if the timing of oxytocin administration in cesarean deliveries will affect the amount of maternal blood loss.
- Conditions
- Blood Loss, Surgical, Postpartum Hemorrhage, Bleed Pregnancy, Pregnancy Related
- Trial name
- I-TOPICS (NCT03246919)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Loyola University
Blood Loss, Surgical
Effect of Aprotinin on Transfusion Requirements and Blood Loss in Patients Undergoing Elective Primary Total Hip Replacement
The purpose of this study is to assess if aprotinin (BAY A0128), given intravenously during surgery, is safe and can help reduce the amount of bleeding and the need for a blood transfusion during hip replacement surgery.
- Trial name
- NCT00668031
- Testing
- Trasylol (Aprotinin, BAYA0128)
- Where
- 40 sites in United States, Canada and 1 more
- Volunteers
- 359 people
- Sponsor
- Bayer
Neurocognitive Disorder, Dexmedetomidine Infusion
Effects of Dexmedetomidine on Postoperative Neurocognitive Disorder
This prospective study involves assessing neurocognitive function in patients undergoing laparotomic gastrointestinal surgery. Mini Mental state Assessment test and Mini-Cog tests will be conducted at multiple intervals…
- Conditions
- Neurocognitive Disorder, Dexmedetomidine Infusion, Postoperative Cognitive Dysfunction, Postoperative Cognitive Dysfunction(POCD)
- Trial name
- NCT06689137
- Testing
- mini mental state assessment test, mini-cog test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital
Blood Loss, Surgical, Second Trimester Abortion
MisOpRostol Effect on Second Trimester Abortion Blood Loss
Although serious complications from second trimester abortion are rare hemorrhage is the most common cause of procedural abortion related morbidity and mortality.
- Trial name
- MORESTABL (NCT06078501)
- Testing
- Misoprostol 400mcg buccal
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University
Pheochromocytoma, Paraganglioma
Prospective Cohort Study of Pheochromocytoma/Paraganglioma
The study will enroll patients scheduled for PPGL removal surgery at Peking Union Medical College Hospital. Before surgery, researchers will use a 6-variable model to predict the patient's risk of experiencing severe blood…
- Conditions
- Pheochromocytoma, Paraganglioma, Hemodynamic Instability, Intraoperative Complications
- Trial name
- NCT07516275
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Cesarean Section Complications, Blood Loss, Surgical
Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida
The aim of the work is to compare the efficacy of preoperative IV tranexamic acid and rectal misoprostol in reducing blood loss in the elective cesarean section.
- Conditions
- Cesarean Section Complications, Blood Loss, Surgical, Misoprostol, Tranexamic Acid
- Trial name
- NCT04635007
- Testing
- Tranexamic acid, Misoprostol 200mcg Tab
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University