Clinical trials: Persian Gulf Syndrome
Gulf War Syndrome, Gulf War Illness
Confirmation of Diet as a Treatment for Gulf War Illness
This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention.
- Trial name
- NCT05675878
- Testing
- Dietary Intervention
- Where
- 3 sites in United States
- Volunteers
- 111 people
- Sponsor
- American University
Gulf War Syndrome
Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness
The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage.
- Trial name
- NCT07266571
- Testing
- Pycnogenol, 100mg, Pycnogenol, 200mg, Pycnogenol, 400mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Syndrome
Clinical Evaluation of Montelukast in Veterans With Gulf War Illness
The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI).
- Trial name
- (GWI) (NCT05992311)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Gulf War Syndrome, Adult Growth Hormone Deficiency
Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)
The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD).
- Trial name
- GWIT (NCT05355272)
- Testing
- Recombinant human growth hormone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Gulf War Illness
Resistant Potato Starch to Alleviate GWI
Gulf War Illness (GWI) affects an estimated 25-32% of the over 700,000 coalition troops deployed to the Persian Gulf as part of the First Gulf War.
- Trial name
- NCT05820893
- Testing
- Resistant Potato Starch
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Gulf War Syndrome, Persian Gulf Syndrome
Coenzyme Q10 for Gulf War Illness: A Replication Study
The purpose of this study is to assess whether a high quality preparation of ubiquinone (coenzyme Q10) benefits symptoms, function, and quality of life in veterans with Gulf War illness.
- Conditions
- Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorder, Respiratory Chain
- Trial name
- NCT06515184
- Testing
- PharmaNord Bio-Quinone Active CoQ10 Gold 100mg
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of California, San Diego
Gulf War Syndrome
Cranial Electrotherapy Stimulation and Brain Imaging for Gulf War Syndrome
The main goal of the proposed study is to critically evaluate a nonpharmacological and readily available therapy, cranial electrical stimulation (CES) using Alpha-Stim™, and to discover the brain function mechanisms underlying…
- Trial name
- NCT07151248
- Testing
- Cranial electrical/electrotherapy stimulation (CES)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Persian Gulf Syndrome, Gulf War Syndrome
Confirming the Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness
This unblinded Phase II clinical trial will test the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners will have had at least 5 years of experience plus…
- Conditions
- Persian Gulf Syndrome, Gulf War Syndrome, Multiple Chronic Illnesses, Occupational Diseases
- Trial name
- CARE (NCT06716411)
- Testing
- Acupuncture
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Gulf War Syndrome, Gulf War Illness
Validating Gulf War Illness Blood Biomarkers
The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI.
- Trial name
- NCT05736146
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Gulf War Syndrome
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum…
- Trial name
- NAC (NCT04987775)
- Testing
- N-Acetyl Cysteine
- Where
- 7 sites in United States
- Volunteers
- 170 people
- Sponsor
- Nova Southeastern University
Gulf War Syndrome
Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness.
The goal of this study is to investigate long-term modulation of pain pathways leading to a suppression of pain symptoms in Gulf War Illness patients by applying transcranial direct current stimulation.
- Trial name
- NCT03547869
- Testing
- Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas at Dallas
Gulf War Illness
Effects of Botanical Microglia Modulators in Gulf War Illness
The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic inflammation that cannot be measured with typical techniques.
- Trial name
- NCT02909686
- Testing
- Boswellia Serrata, Curcumin, Epimedium
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Syndrome
Assessing Neuroinflammation in GWI Using MRS
The primary aim of this study is to determine if Gulf War Illness (GWI) likely involves neuroinflammation. The investigators hypothesize that GWI involves neuroinflammation.
- Trial name
- NCT04638998
- Testing
- Magnetic Resonance Spectroscopic Imaging, Blood draw
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Persian Gulf Syndrome, Mycoplasma Infections
Antibiotic Treatment of Gulf War Veterans' Illnesses
In 1990 and 1991, the U.S. deployed approximately 700,000 troops to the Persian Gulf to liberate Kuwait from Iraqi occupation. While there were few casualties associated with the Gulf War, many individuals returned from this…
- Trial name
- NCT00007735
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Gulf War Syndrome, Gulf War Illness
Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms
This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.
- Conditions
- Gulf War Syndrome, Gulf War Illness, Headache, Muscle Pain
- Trial name
- NCT04182659
- Testing
- Transcranial Magnetic Stimulation
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Veterans Medical Research Foundation
Gulf War Syndrome, Persian Gulf Syndrome
Mitochondrial Cocktail for Gulf War Illness
The purpose of this study is to develop preliminary evidence, such as effect size and variance estimates, to guide successful conduct of a properly-powered clinical trial to assess the benefit of a mitochondrial cocktail…
- Conditions
- Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorders
- Trial name
- NCT02804828
- Testing
- Individualized mitochondrial cocktail
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Diego
Gulf War Syndrome
Ketamine in Veterans With Gulf War Illness
Up to one third of the 700,000 U.S. military veterans of the 1990-91 Gulf War have Gulf War Illness (GWI), a symptom complex characterized by a combination of chronic pain, cognitive impairment, debilitating fatigue…
- Trial name
- NCT04712071
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Gulf War Syndrome
Glutamate Neuro-Excitotoxicity in GWI
The objective of the proposed research is to examine whether dietary exposure to food additives containing glutamate may be contributing to symptoms in Gulf War Illness (GWI).
- Trial name
- GWI (NCT03342482)
- Testing
- Low-glutamate diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- American University
Gulf War Illness, Persian Gulf Syndrome
Understanding GWI: Integrative Modeling
The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness.
- Conditions
- Gulf War Illness, Persian Gulf Syndrome, Occupational Diseases
- Trial name
- NCT04255498
- Testing
- Etanercept, Mifepristone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- South Florida Veterans Affairs Foundation for Research and Education
Gulf War Syndrome
Glutathione vs. Curcumin Clinical Trial
The investigator proposes to perform a phase I/II study comparing two nutraceuticals and placebo that target mediators identified in the investigator's prior dynamic modeling study of Gulf War Illness (GWI).
- Trial name
- Glutathione (NCT02848417)
- Testing
- Curcumin, Glutathione
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- South Florida Veterans Affairs Foundation for Research and Education