Clinical trials: Persistent Disease
Achalasia
Achalasia: Mechanisms Underlying Treatment Failure
In patients with achalasia, the relationship between the perception of dysphagia, oesophageal emptying, lower oesophageal sphincter (LOS) distensibility and oesophageal circular and longitudinal muscle contraction is not clear.
- Trial name
- NCT02055469
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Asthma Atopic, Asthma Severe Persistent Uncontrolled
Expression of TSLP Isoforms in Asthma
Asthma is a heterogeneous disease characterized by chronic airway inflammation, leading to variable airflow obstruction, bronchial hyperresponsiveness, excessive mucus secretion, and, consequently, structural airway remodeling.
- Trial name
- NCT07786870
- Testing
- No Intervention: Observational Cohort
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Onychomycosis
Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenail
The purpose of the study is to determine whether NB002, 0.25%, and 0.5% are safe and effective in the treatment of distal subungual onychomycosis of the toenail.
- Trial name
- NCT00453271
- Testing
- NB-002, Vehicle control
- Where
- 24 sites in United States, Canada
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- NanoBio Corporation
Atrial Fibrillation
Study of the Effect of Cardioversion on Cardiac Volume in Patients With Persistent Atrial Fibrillation
The main objectives in this study were to examine the cardiac structural and functional changes in patients with persistent and permanent AF, with the aim of improving our understanding of the underlying pathophysiological…
- Trial name
- NCT00209911
- Testing
- cardioversion
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Age Related Macular Degeneration
A Pilot Study to Evaluate the Role of High-dose Ranibizumab (2.0mg) in the Management of AMD in Patients With Persistent/Recurrent Macular Fluid Less Than 30 Days Following Treatment With Intravitreal Anti-VEGF Therapy (the LAST Study)
This is a single-masked study to compare intravitreally administered 0.5 mg ranibizumab to 2.0 mg ranibizumab in subjects who manifest persistent or recurrent macular fluid less than 30 days following treatment with intravitreal…
- Trial name
- LAST (NCT01115556)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Musculoskeletal Pain
Health Complaints in Adolescence and Future Persistent Musculoskeletal Pain
Persistent musculoskeletal (MSK) pain in adolescence is associated with disability, absence from school and reduced quality of life.
- Trial name
- NCT05036746
- Testing
- No intervention
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Persistent Postural Perceptual Dizziness
Using Glialia for Treating Persistent Perceptual Postural Dizziness
This pilot study will involve 30 participants recruited from the Santa Lucia Foundation IRCCS, including 20 patients diagnosed with Persistent Perceptual Postural Dizziness (PPPD), and might or might not have previously…
- Trial name
- GLI-PPPD (NCT06741358)
- Testing
- Glialia, Control
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Atrial Fibrillation
Wide Area Circular Ablation Versus Extra-wide Area Circular Ablation in Persistent Atrial Fibrillation
Ablation of atrial fibrillation is an established method for treatment of subjects with atrial fibrillation with goal of restoration of sinus rhythm.
- Trial name
- WACAvsEWACA (NCT02814136)
- Testing
- Ablation
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Mosaic Life Care
Mental Disorders
Efficacy of the Recovery Workbook as a Psychoeducational Tool for Facilitating Recovery
The present study will determine if Spaniol and colleague's (1994) Recovery Workbook group intervention is an effective clinical tool to move a person with SMI along in their journey of recovery.
- Trial name
- NCT00375167
- Testing
- Recovery Workbook Training (psychoeducational training), ACT as usual
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Queen's University
HIV-1 Infection
Pilot Trial of the Effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection
The purpose of this research study is to 1) evaluate the safety of a series of injections with the AGS-004 product in combination with a series of Vorinostat doses and 2) to help scientists evaluate ways of reactivating latent…
- Trial name
- VORVAX (NCT02707900)
- Testing
- Vorinostat, AGS-004
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Meningococcal Meningitis, Meningococcal Infections
Persistence of Protective Antibody Titers 12-24 Months After NmVac4-A/C/Y/W-135-DT Vaccination: Follow Up Study
To determine the persistence of protective antibody levels for subjects who seroconverted after vaccination with NmVac4-A/C/Y/W-135-DT™ Participants in trial # JN-NM-002, who seroconverted for serogroups A and C will be contacted…
- Trial name
- NCT02500511
- Testing
- NmVac4-A/C/Y/W-135-DT™
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- JN-International Medical Corporation
Persistent Atrial Fibrillation
A Study on the Therapeutic Value of Additional Left Atrial Posterior Wall Isolation Guided by Voltage Mapping in Persistent Atrial Fibrillation.
This prospective, multicenter, randomized controlled study was designed to investigate the feasibility, efficacy and safety of pulsed field ablation (PFA) strategies for persistent atrial fibrillation.
- Trial name
- NCT07590661
- Testing
- superior vena cava isolation, Abnormal left atrial substrate
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Hangzhou Dinova EP Technology Co., Ltd
SARS-CoV-2, COVID-19
Rapid Diagnostic Profiling of SARS-CoV-2 (COVID-19)
The investigators will evaluate the profile of the immune response of Ethiopian population and examine its relationship with the noted low CD4+ T-cell count and underlying immune activation status among participants with COVID-19…
- Trial name
- Profile-Cov (NCT04473365)
- Testing
- Intestinal parasite
- Where
- Ethiopia
- Volunteers
- 838 people, healthy volunteers welcome
- Sponsor
- Mekelle University
Persistent Atrial Fibrillation
Liner Ablation Using Contact-force in Atrial Fibrillation
Linear ablation is frequently used in the procedure for persistent atrial fibrillation. However, it has a limitation because of technical difficulty. Incomplete block is common and an important cause of atrial tachycardia.
- Trial name
- LIBCAAF (NCT03091972)
- Testing
- Pulmonary vein isolation, Contact force assisted left atrial linear ablation, left atrial linear ablation without contact force monitoring
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Major Depressive Episode, Covid19
Neuroinflammation in COVID-19 and Depression
The purpose of this study is to use state of the art brain imaging technology to investigate neuroinflammation in participants with depression after the respiratory symptoms of coronavirus disease 2019 (COVID-19) have passed.
- Trial name
- NCT04854785
- Testing
- [18F]FEPPA PET scan, [11C]SL25.1188 PET scan
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Soil-transmitted Helminthiasis, Schistosomiasis
Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders
NIDIAG is an international collaboration on integrated diagnosis-treatment platforms, funded by the European Commission (EC). NIDIAG aims to develop an improved, patient-centred system for delivering primary health care in…
- Conditions
- Soil-transmitted Helminthiasis, Schistosomiasis, Strongyloidiasis, Shigellosis
- Trial name
- NIDIAGDigest (NCT02105714)
- Testing
- Stool culturing for pathogenic bacteria, Kato-Katz technique, Baermann technique
- Where
- 7 sites in Côte d’Ivoire, Indonesia and 2 more
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Pregnancy Related, Fetal; Circulation
Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes
The aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at…
- Trial name
- NCT04686240
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Preeclampsia Severe or Mild, Cardiac Complication
Persistent Postpartum Cardiovascular Dysfunction in Patients With Preeclampsia
The investigators plan to enroll women with PE prospectively to evaluate incremental cardiovascular risk in those who have PE with severe features. This study includes detailed echocardiographic evaluation at several time points.
- Trial name
- ECHO (NCT04063397)
- Testing
- Echocardiogram, Blood draw
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Atrial Fibrillation, Atrial Fibrillation, Persistent
Ivabradine for Rate Control in Permanent Atrial Fibrillation
Ivabradine may be useful as a rate controlling agent in atrial fibrillation without negative effects on hemodynamics and inotropy.
- Trial name
- NCT03987204
- Testing
- Ivabradine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University