Clinical trials: Persistent Vegetative State
Disorder of Consciousness, Vegetative State
Cerebellar iTBS in Patients With Disorders of Consciousness
Previous studies showed the excitatory effect of cerebellar transcranial magnetic stimulation(TMS) on motor cortex.Investigator evaluate the effects of bilateral cerebellar TMS on Coma Recovery Scale-Revised (CRS-R) scores in…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- CTPDOC (NCT05558930)
- Testing
- iTBS stimulation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital
Brain Injury
Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury
The purpose of this study is to test the drug apomorphine in subjects who are in a Vegetative State or a Minimally Conscious State.
- Trial name
- NH001-2 (NCT00761228)
- Testing
- Apomorphine
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.
Brain Injury
A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness
This is a study to evaluate the safety and efficacy of the IBRF ACP/MCP intervention protocol in patients with severe disorders of consciousness (SDOC).
- Trial name
- NCT02696512
- Testing
- Polypharmacy using FDA-approved products, Median Nerve Stimulation (MNS), Nutraceutical Supplementation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- International Brain Research Foundation
Disorders of Consciousness
Window On the Brain
Disorders of consciousness (DOC) diagnosis suffers from the difficulty to measure the level of consciousness due to the variability associated with behavioural assessments and the difficulty in detecting the residual level of…
- Trial name
- WOB (NCT06693492)
- Testing
- Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Disorder of Consciousness
Clinical Validity of the Minimally Conscious State "Plus" and "Minus"
The goal of this observational retrospective study is to investigate and compare the clinical evolution of a sample of patients with the diagnosis of MCS+ versus MCS- according to the CRS-R.
- Trial name
- NCT05954650
- Testing
- Rehabilitation
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Hospitales Nisa
Disorders of Consciousness
Beneficial Effects of Preference on Behavior in DOC Patients (COGNICOMA)
Preferred music improves cognitive function in patients with disorders of consciousness (DOC). However, it is still unknown whether it is a general effect of music (because of its acoustic features) or an autobiographical effect…
- Trial name
- COGNICOMA (NCT02759068)
- Testing
- sounds and odors
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Minimally Conscious State, Vegetative State
Reliability and Validity of the NCS (NCS-R)-Chinese Version
The aim of this study was to translate the NCS from English into Chinese and determine the validity of this Chinese version.
- Trial name
- NCT03494218
- Testing
- Nociception Coma Scale (NCS)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Hangzhou Normal University
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Vegetative State, Minimally Conscious State
Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal (DLPF) cortex transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- tDCS in DOC (NCT01673126)
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- University of Liege
Chronic Vegetative State
The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI Study
The aim is to evaluate the impact of RPh201 on brain activity in chronic vegetative state patients. The assessment will be done using clinical measurements and functional MRI studies.
- Trial name
- RPh-in-CVS (NCT01438684)
- Testing
- RPh201, Saline
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Disorder of Consciousness, Minimally Conscious State
Diagnostic Accuracy of the Vegetative and Minimally Conscious State
The aim of this study was to investigate diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment
- Trial name
- NCT04139239
- Testing
- Coma Recovery Scale-revision
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hangzhou Normal University
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Vegetative State, Minimally Conscious State
Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Previous studies showed that transcranial direct current stimulation (tDCS) transiently improves performance of motor function in stroke patients, as well as decrease muscle hypertonia.
- Conditions
- Vegetative State, Minimally Conscious State, Spasticity, Muscle, Disorder of Consciousness
- Trial name
- NCT03797573
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- University of Liege
Disorder of Consciousness
Treating Severe Brain-injured Patients With Apomorphine
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness. Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical options.
- Trial name
- NCT03623828
- Testing
- Apomorphine Hydrochloride 50Mg/10mL Prefilled Syringe
- Where
- 2 sites in Belgium
- Volunteers
- 8 people
- Sponsor
- University of Liege
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Coma
The Efficacy of Familiar Voice Stimulation During Coma Recovery
The purpose of the study is to determine whether familiar vocal stimulation, provided during coma recovery, improves outcomes for persons who are unconscious after severe TBI.
- Conditions
- Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
- Trial name
- FAST (NCT00557076)
- Testing
- Familiar Auditory Sensory Training
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Disorders of Consciousness, Vegetative State
AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness
Disorders of consciousness (DoC) are severe neurological conditions characterized by impaired awareness and reduced interaction with the environment.
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- AI-HBOT-DoC (NCT07855848)
- Testing
- AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Disorder of Consciousness
A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness
The research contains two parts. Part 1: To explore whether EEG responses to zolpidem can assess consciousness circuit integrity and predict the evolution of consciousness in patients with prolonged disorders of consciousness…
- Trial name
- NCT02948660
- Testing
- Zolpidem Tartrate Tablets
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital