Clinical trials: Persistent Vegetative State
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Persistent Vegetative State
Emotion Assessment to Study Consciousness in Awakening Patients
After a coma, one important challenge is the detection of awareness with patients with disorders of consciousness. For some patients, the only behavioral manifestation indicative of awareness is an appropriate emotional response.
- Trial name
- EmotiCones (NCT03706170)
- Testing
- Physiological recording in response to different types of stimuli, EEG recording in response to different types of stimuli
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Chronic Consciousness Disorders, Vegetative State
Vagal Nerve Stimulation in Coma Patients
Minimally Conscious (MCS) or Vegetative State (VS) are disorders of consciousness which often occur following traumatic brain injury or ischemia.
- Conditions
- Chronic Consciousness Disorders, Vegetative State, Minimally Conscious State, Akinetic Mutism
- Trial name
- SNV (NCT02591069)
- Testing
- stimulation device
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Hospices Civils de Lyon
Consciousness Disorder, Brain Injuries
Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility Study
This study evaluates the feasibility of an experimental protocol that combines advanced multi-modal imaging of the brain with clinical and behavioural scales to characterise the neural, behavioural, and clinical effects of…
- Conditions
- Consciousness Disorder, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- RAINDROP (NCT04248946)
- Testing
- Transcranial direct current stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Birmingham
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Auditory Processing in DOC Patients
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe…
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- AUD-DOC (NCT07455682)
- Testing
- Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Disorders of Consciousness, Minimally Conscious State
Aiming for a Better Understanding and Improvement of the Diagnosis and Prognosis of Patients With Disorders of Consciousness Through Multimodal Observations
Improved treatment of severe brain injuries has resulted in increased survival rates. While some of these patients regain consciousness after a transient state of coma, others may develop a disorder of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Caregivers
- Trial name
- PerBrain (NCT04798456)
- Testing
- Coma scales, Imaging, electrophysiology, body signals, and brain stimulation, Questionnaires
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Paris Brain Institute (ICM)
Vegetative State, Minimally Conscious State
Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders. Notably, transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal cortex has proved…
- Conditions
- Vegetative State, Minimally Conscious State, Disorder of Consciousness
- Trial name
- NCT03823508
- Testing
- anodal tDCS
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University of Liege
Consciousness Disorder, Minimally Conscious State
Transcutaneous Auricular Vagal Nerve Stimulation for Post-coma Patients With Disorders of Consciousness
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders of consciousness. Notably, a case reported improvement of level of consciousness using transcutaneous auricular vagal…
- Conditions
- Consciousness Disorder, Minimally Conscious State, Vegetative State
- Trial name
- NCT04065386
- Testing
- Active taVNS
- Where
- 2 sites in Belgium
- Volunteers
- 44 people
- Sponsor
- University of Liege
Disorder of Consciousness, Minimally Conscious State
Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Cognitive Impairment
- Trial name
- STIMCOM (NCT03007784)
- Testing
- transcranial direct current stimulation (tDCS) / Comparison of current intensities
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Brain Injury
Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury
The purpose of this study is to test the drug apomorphine in subjects who are in a Vegetative State or a Minimally Conscious State.
- Trial name
- NH001-2 (NCT00761228)
- Testing
- Apomorphine
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.
Vegetative State, Minimally Conscious State
Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Previous studies showed that transcranial direct current stimulation (tDCS) transiently improves performance of motor function in stroke patients, as well as decrease muscle hypertonia.
- Conditions
- Vegetative State, Minimally Conscious State, Spasticity, Muscle, Disorder of Consciousness
- Trial name
- NCT03797573
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- University of Liege
Disorders of Consciousness
Window On the Brain
Disorders of consciousness (DOC) diagnosis suffers from the difficulty to measure the level of consciousness due to the variability associated with behavioural assessments and the difficulty in detecting the residual level of…
- Trial name
- WOB (NCT06693492)
- Testing
- Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Minimally Conscious State, Vegetative State
The Effects of Olfactory Stimulation on Diagnosis and Prognosis of DOC Patients
Analyze the behavioral response of patients with disorders of consciousness through olfactory stimulation, compare the response of olfactory stimulation in patients with different consciousness, and analyze the impact of…
- Trial name
- NCT03732092
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jing Wang
Traumatic Brain Injury
Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness
The purpose of this study is to examine the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with Amantadine relative to rTMS Alone and Amantadine Alone for persons in chronic states of…
- Trial name
- NCT02025439
- Testing
- rTMS, Amantadine
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Edward Hines Jr. VA Hospital
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acquired Brain Injury, Coma
Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study
This is a pilot study. The objective is to further understand the mechanism by which amantadine improves function in patients with persistent vegetative state and minimally conscious state.
- Conditions
- Acquired Brain Injury, Coma, Persistent Vegetative State, Minimally Conscious State
- Trial name
- NCT02566720
- Testing
- Amantadine, MRI Tractography Study
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Hamilton Health Sciences Corporation
Minimally Conscious State, Vegetative State
Reliability and Validity of the NCS (NCS-R)-Chinese Version
The aim of this study was to translate the NCS from English into Chinese and determine the validity of this Chinese version.
- Trial name
- NCT03494218
- Testing
- Nociception Coma Scale (NCS)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Hangzhou Normal University
Disorder of Consciousness, Minimally Conscious State
Spinal Cord Stimulation in Patients With Disorders of Consciousness
Disorders of consciousness(DOC) is the most serious complications and has been widely paid attention to by the government. DOC patients cause large social and economic burden to our society for there has no effective cure so far.
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT04010838
- Testing
- spinal cord stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huashan Hospital