Clinical trials: Persistent or Long-standing Persistent Atrial Fibrillation
Atrial Fibrillation, Persistent or Longstanding Persistent Atrial Fibrillation
Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presenting with Persistent Atrial Fibrillation or Longstanding Persistent Atrial…
- Trial name
- DEEP (NCT02393885)
- Testing
- AtriCure Bipolar System and AtriClip® PRO LAA Exclusion System, Endocardial Ablation
- Where
- 17 sites in United States, Belgium and 1 more
- Volunteers
- 90 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Dual Epicardial Endocardial Persistent Atrial Fibrillation(AF) Study (Staged DEEP)
The purpose of this study is to assess the safety and technical feasibility of treating subjects with Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation in a minimally invasive thoracoscopic ablation…
- Trial name
- Staged DEEP (NCT01661205)
- Testing
- Ablation procedure staged catheter ablation
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 30 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation, Tachycardia
Long-Standing Persistant Atrial Fibrillation-Pulmonary Vein Isolation With or Without Ablation
The chronic success rate, defined as freedom from any atrial tachyarrhythmias will increase from 35% to 60% by ablation of complex fragmented atrial electrograms potentials in addition to pulmonary vein isolation (PVI) as…
- Trial name
- Alster-Lost (NCT00820625)
- Testing
- pulmonary vein isolation, pulmonary vein isolation with additional ablation of fragmented potentials
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- Asklepios proresearch
Atrial Fibrillation
The Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation
This prospective study aims; 1. To assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome 2.
- Trial name
- IMPACT (NCT01148914)
- Testing
- Inflammatory biomarkers
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
Second Study to Assess Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Long Standing Persistent Atrial Fibrillation
Pulmonary vein isolation (PVI) combined with empiric ablation of either common sites of non-PV triggers of Atrial Fibrillation (AF) and locations that may sustain stable AF sources should be more efficacious than PVI combined…
- Trial name
- RASTA XT (NCT02019238)
- Testing
- Pulmonary Vein Isolation procedure
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Atrial Fibrillation
CONVERGE CAP Study-For The Treatment Of Symptomatic Persistent or Long-standing Persistent AF
The objective of this clinical study is to collect additional data on the safety and effectiveness of the EPi- Sense®-AF Guided Coagulation System with VisiTrax® to treat symptomatic persistent or long-standing persistent Atrial…
- Trial name
- CAP (NCT04239534)
- Testing
- Convergence Of Epicardial And Endocardial RF Ablation
- Where
- 10 sites in United States, United Kingdom
- Sponsor
- AtriCure, Inc.
Long Standing Persistent Atrial Fibrillation
Long-term Outcomes in Long Standing Persistent Atrial Fibrillation
Atrial fibrillation (AF) is a condition detected as an irregular heartbeat. It is the most common rhythm disturbance worldwide which can lead to significant symptoms and serious health problems (stroke and heart failure).
- Trial name
- LoTO_CASA_AF (NCT04280042)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Persistent Atrial Fibrillation
Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation
The purpose of this prospective randomized study is to assess whether empirical Left Atrial Appendage (LAA) isolation along with the standard approach of pulmonary vein isolation (PVI) and ablation of extra-pulmonary triggers is…
- Trial name
- BELIEF (NCT01362738)
- Testing
- RFCA of PV and extra-PV triggers, LAA isolation along with the conventional ablation strategy
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Persistent or Long-standing Persistent Atrial Fibrillation
Additional Left Atrial Appendage Isolation During Balloon Ablation for Persistent or Long-standing Persistent Atrial Fibrillation
Additional left atrial appendage isolation during balloon ablation for persistent or long-standing persistent atrial fibrillation can reduce atrial fibrillation reoccurrence within 3-12 months compared to balloon-based pulmonary…
- Trial name
- LALA-LAND-AF (NCT04240366)
- Testing
- Control intervention, Experimental intervention
- Where
- 3 sites in Germany
- Volunteers
- 350 people
- Sponsor
- University of Luebeck
Atrial Fibrillation
Ablation and Left Atrium Reduction During Mitral Valve Surgery for Atrial Fibrillation
The purpose of this study is to estimate left atrial volume reduction surgery concomitant with the maze procedure and mitral valve repair/replacement in patients with atrial fibrillation with an enlarged left atria.
- Trial name
- ALARM-vs-AF (NCT02047279)
- Testing
- maze procedure, mitral valve surgery, left atrial reduction
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Arteriosclerosis, Atrial Fibrillation
A(f)MAZE-CABG Study
Concomitant AF ablation with HIFU in patients with persistent or long standing persistent AF undergoing CABG will be superior in restoring SR, compared with patients with persistent or long standing persistent AF undergoing CABG…
- Conditions
- Coronary Arteriosclerosis, Atrial Fibrillation, Coronary Artery Bypass Graft Surgery
- Trial name
- AFMAZE-CABG (NCT00735722)
- Testing
- HIFU AF Ablation
- Where
- 10 sites in Canada, Finland and 4 more
- Volunteers
- 188 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation Chronic, Persistent Atrial Fibrillation
Comparison of Pulmonary Vein Ablation With or Without Left Atrial Posterior Wall Ablation for Persistent AF (PIVoTAL)
The purpose of this study it to learn whether pulmonary vein isolation (PVI) along with ablation of the posterior left atrial wall (PLAW) will reduce the likelihood of atrial fibrillation (AF) recurrence in patients with…
- Trial name
- PIVoTAL (NCT03057548)
- Testing
- Cryo or Radiofrequency (RF) Ablation only of Pulmonary Veins, Cryo or RF Ablation of Pulmonary Veins plus Ablation of the PLAW
- Where
- 2 sites in United States, Japan
- Volunteers
- 110 people
- Sponsor
- Arash Aryana, MD
Atrial Fibrillation
Two-stage Hybrid Ablation or Thoracoscopic Epicardial Ablation for Long-standing Persistent Atrial Fibrillation
Hybrid ablation, as an emerging strategy for atrial fibrillation (AF) in recent years, shows encouraging outcomes in many medical centers.
- Trial name
- THAT-LSPAF (NCT03708471)
- Testing
- Hybrid ablation, Thoracoscopic surgical ablation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangdong Academy of Medical Sciences
Persistent Atrial Fibrillation Longstanding
Multitarget Pulse Field Ablation Guided by Endocardial and Non-invasive Atrial Driver Mapping (PFA+ADM) Pilot Study. Development of an Ablation Strategy to Improve the Efficacy of Long Standing Atrial Fibrillation Ablation in Patients With High Comorbidity Burden or Heart Failure
To assess the efficacy and safety of a percutaneous ablation strategy that targets multiple extrapulmonary structures as the Cox-Maze IV.
- Trial name
- PFA+ADM (NCT07118488)
- Testing
- Multitarget PFA Ablation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Innovacion en Biomedicina (FIBMED)