Clinical trials: Personalized Medicine
Coronary Heart Disease
Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease
Cardiometabolic diseases are major causes of morbidity and mortality in the state of Wisconsin and are expected to pose an increasing burden over the next few decades.
- Trial name
- RESPOND (NCT07260552)
- Testing
- Polygenic risk score
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Parkinson Disease
Developing Personalized Medicine Strategies to Increase Physical Activity in Parkinson's Disease (PD) Through Digital Health Technology
Under a grant from the Department of Defense's PD program, Dr. Morley's is investigating new approaches that 1) use "gamification"- applying rules of games like point scoring, achieving silver, gold or platinum levels and…
- Trial name
- NCT05529121
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Hematopoietic Cell Transplantation, Oncology
Pharmacogenomic-Guided Supportive Care in Hematopoietic Cell Transplantation
Hematopoietic cell transplantation (HCT) is the only curative treatment modality for many hematologic malignancies. Morbidity and mortality rates have declined drastically over the years, secondary to improvements in both…
- Trial name
- IMPPACT (NCT04727827)
- Testing
- Pharmacogenomic-guided supportive care
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy Volunteers, Liver Cancer
4D-MRI for Precision Medicine
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI).
- Conditions
- Healthy Volunteers, Liver Cancer, Lung Cancer
- Trial name
- NCT04657042
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Wheezing
PREcision Medicine Directed Corticosteroids In Children With preSchool Wheeze
Young children frequently attend the emergency department (ED) with wheeze which is usually triggered by a virus infection, such as the common cold.
- Trial name
- PRECISE (NCT06580600)
- Testing
- Point of care respiratory virus testing
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Primary Prevention, Healthy Aging
Personalized Disease Prevention
This study will evaluate whether patients and their providers benefit from an evidence-based decision tool to help prioritize preventive (and select chronic disease management) services based on their potential to improve…
- Conditions
- Primary Prevention, Healthy Aging, Quality of Life, Decision Support Techniques
- Trial name
- PDP (NCT05463887)
- Testing
- Individualized preventive care recommendations (decision tool)
- Where
- United States
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- Glen Taksler
Depression - Major Depressive Disorder
Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine
This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan.
- Trial name
- NCT07500714
- Testing
- Internet Cognitive-Behavioral Therapy
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Science and Technology Council, Taiwan
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Alzheimer Disease, Cognitive Decline
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Alzheimer's disease (AD) neuropathology is characterized by deposits of insoluble amyloid β-peptide (Aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles.
- Trial name
- (PENSA) (NCT03978052)
- Testing
- EGCG, Healthy lifestyle recommendations, Multimodal lifestyle intervention
- Where
- 2 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Obesity, Rhinitis
Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application
The purpose of this study is to study interactions between genes, lifestyle environmental factors like foods, nutritional supplements and non-invasive medical devices and health factors that can be measured without specialized…
- Conditions
- Obesity, Rhinitis, Rhinitis, Allergic, Respiratory Sounds
- Trial name
- NCT02758990
- Testing
- Vitamin A, Vitamin B6, Vitamin C
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Verifomics LLC
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA)
Identification of Biomarkers of Obstructive Sleep Apnea.
Obstructive sleep apnea (OSA) is a common sleep disorder associated with intermittent hypoxia, systemic inflammation, oxidative stress, and an increased risk of cardiovascular and metabolic diseases.
- Conditions
- Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA), Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS)
- Trial name
- NCT07723144
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Health, Subjective, Gastrointestinal Dysfunction
Personal Lifestyle Engine (PLX) - Personal Lifestyle Medicine Center (PLMC)
It has been suggested that the best medicine should include four principles (4P) - Medicine should be personalized, predictive, preventative and participatory.
- Conditions
- Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases
- Trial name
- NCT04007939
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Dilated Cardiomyopathy
Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study
The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is an ancillary study from the parent study, DCM Precision Medicine Study.
- Trial name
- NCT04638621
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Individuality, Healthy
Vaccination Responses in Young and Older Adults
To follow longitudinally healthy and immune-compromised responses to pneumococcal vaccination, in 60+ individuals towards the development of personalized medicine implementation (minimum enrollments in 2 age categories: young…
- Conditions
- Individuality, Healthy, Asthma, Immune System and Related Disorders
- Trial name
- NCT02654704
- Testing
- Pneumococcal Vaccination
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Cancer, Gastric
Gastric Cancer Risk Factors Associated With EU and CELAC Populations
The study uses a case-control design that examines the differences in types of exposures between cases defined with a pathological confirmation of GC diagnosis, and controls, defined as patients to whom a gastroscopy was…
- Trial name
- LEGACY-1 (NCT03957031)
- Where
- 8 sites in Argentina, Chile and 5 more
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Alzheimer Disease
Alzheimer's Disease and Precision Medicine Research Among Native People
This project intends to address the gaps in Alzheimer's disease (AD) and precision medicine (PM) research in American Indian and Alaska Native (AI/AN) populations by comparing written and video-based materials for recruitment…
- Trial name
- NCT03448601
- Testing
- Culturally tailored brochure intervention group, Culturally tailored video intervention group
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Respiratory Depression
Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression
The concept of precision medicine - taking individual variability into account when planning preventions and interventions - is not new but is quickly gaining attention in this age of powerful methodology of patient…
- Trial name
- NCT03441282
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham