Clinical trials: Personalized Medicine
PreDiabetes
Precision Medicine for Preventing Type 2 Diabetes: a Step Forward
The prevalence of type 2 diabetes (T2D) has been rising rapidly with an increased burden to the healthcare system. As such T2D prevention is highly recommendable, and, theoretically, it can definitely be successful.
- Trial name
- PRE-MED2 (NCT05147961)
- Testing
- Digital Health, Standard care
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Microbial Colonization
Microbiome Derived Metabolism and Pharmacokinetics
The investigators will perform single-dose pharmacokinetic (PK) studies in humans following administration of drugs with known microbiome derived metabolism (MDM) in parallel with preclinical studies.
- Trial name
- MDM-PK (NCT05065671)
- Testing
- Tolcapone 100 MG, Duloxetine 20 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Diabetes Mellitus, Type 2
Effect of Type 2 Diabetes Genetic Risk Information on Health Behaviors and Outcomes
The primary objective of the study is to assess the clinical utility of a genetic test for Type 2 diabetes risk in combination with standardized risk assessment compared with standardized risk assessment alone, and to measure…
- Trial name
- TDE (NCT00849563)
- Testing
- Standardized Risk Assessment
- Where
- 2 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Duke University
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Individuality, Healthy
Vaccination Responses in Young and Older Adults
To follow longitudinally healthy and immune-compromised responses to pneumococcal vaccination, in 60+ individuals towards the development of personalized medicine implementation (minimum enrollments in 2 age categories: young…
- Conditions
- Individuality, Healthy, Asthma, Immune System and Related Disorders
- Trial name
- NCT02654704
- Testing
- Pneumococcal Vaccination
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Breast Cancer, BRCA1 Mutation
Decision Support for BRCA Testing in Ethnically Diverse Women
The objective of this study is to expand genetic testing for hereditary breast and ovarian cancer syndrome to a broader population of high-risk women by prompting appropriate referrals from the primary care setting with the use…
- Conditions
- Breast Cancer, BRCA1 Mutation, BRCA2 Mutation, Ovarian Cancer
- Trial name
- NCT03470402
- Testing
- RealRisks, BNAV, iNYP
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Columbia University
Heart Attack
The Role of Genetic Factors in the Development of Myocardial Infarction in the Kazakh Population
This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population.
- Trial name
- NCT05090618
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
Parkinson Disease
Developing Personalized Medicine Strategies to Increase Physical Activity in Parkinson's Disease (PD) Through Digital Health Technology
Under a grant from the Department of Defense's PD program, Dr. Morley's is investigating new approaches that 1) use "gamification"- applying rules of games like point scoring, achieving silver, gold or platinum levels and…
- Trial name
- NCT05529121
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Healthy Subjects
Right Drug, Right Dose, Right Time - Using Genomic Data to Individualize Treatment
This study is being done to better understand how genetic information related to drug dosing and use can affect medical care of patients.
- Trial name
- NCT03803293
- Testing
- Pharmacogenomic testing
- Volunteers
- 11,098 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2 Diabetes
The Hong Kong Diabetes Biobank
Asia is in the midst of an epidemic of diabetes. Epidemiological figures suggest that there are more than 110 million people affected by diabetes in China, with a significant proportion of young adults already affected.
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Diabetic Nephropathies
- Trial name
- HKDB (NCT05282680)
- Testing
- prospective observational study
- Where
- Hong Kong
- Volunteers
- 48,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Healthy, Immune System and Related Disorders
The Healthy Human Global Project - Hong Kong (HHGP-Hong Kong)
The Healthy Human Global Project-Hong Kong aims to elucidate the heritable and non-heritable factors that drive immunological variance within a healthy population in Hong Kong.
- Trial name
- NCT05174624
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,026 people, healthy volunteers welcome
- Sponsor
- Centre for Immunology & Infection
Epilepsy
Precision Medicine in the Treatment of Epilepsy
Primary objectives: The purpose of this study is to identify single and composite biomarkers (from neuroimaging, electrophysiological, and non-imaging biological measures), clinical measures (from cognitive, psychometric, and…
- Trial name
- BDE (NCT05450822)
- Testing
- Levetiracetam, Levetiracetam Tablets, Lamotrigine tablet
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Any Disease Condition and Reportedly-healthy Subjects
Precision Genomics Medicine Biobank
The immediate goal of this study is to collect biological samples (i.e., tissue and/or fluid), clinical information, and laboratory data from disease and non-disease subjects seen at Intermountain Healthcare affiliated…
- Trial name
- PRECISE (NCT04187729)
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Shoulder Pain
Biopsychosocial Influence on Shoulder Pain
Chronic shoulder pain is a common, costly, and disabling problem for society. The identification of factors predictive of the development of chronic shoulder pain is necessary to develop innovative and effective treatments to…
- Trial name
- BISP (NCT02620579)
- Testing
- Propranolol LA (60 mg), Shoulder Anatomy Education, Pain Processing Education
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Duke University
Chest Pain, Coronary Artery Disease
A Registry to Evaluate Patterns of Care Associated With the Use of Corus CAD (or ASGES) in Primary Care Settings
The PRESET Registry--A Registry to Evaluate Patterns of Care Associated With the Use of Corus CAD (Age/Sex/Gene Expression score - ASGES) in Real World Clinical Care Settings (PRESET)--was designed as an observational…
- Conditions
- Chest Pain, Coronary Artery Disease, Cardiovascular Diseases, Coronary Heart Disease
- Trial name
- PRESET (NCT01677156)
- Testing
- CORUS CAD (ASGES)
- Where
- 13 sites in United States
- Volunteers
- 713 people, healthy volunteers welcome
- Sponsor
- CardioDx
Obesity, Rhinitis
Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application
The purpose of this study is to study interactions between genes, lifestyle environmental factors like foods, nutritional supplements and non-invasive medical devices and health factors that can be measured without specialized…
- Conditions
- Obesity, Rhinitis, Rhinitis, Allergic, Respiratory Sounds
- Trial name
- NCT02758990
- Testing
- Vitamin A, Vitamin B6, Vitamin C
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Verifomics LLC
Poor Quality Sleep
A Novel Strategy to Develop a Rapid Screen, Simple Subgrouping and Precise Intervention Model for Older Adults With Poor Sleep Quality
Poor sleep quality is a major issue of public health in older adults. However, the underlying cause of poor sleep quality in older adults is multifactorial and complex.
- Trial name
- NCT04033601
- Testing
- Non-pharmacological intervention
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
This observational study compares the phenotypic variability (clinical and biological) in treatment response to systemic corticosteroids according to the blood eosinophil count and FeNO in physician-diagnosed ≥12-year-old…
- Trial name
- PRISMA (NCT05870215)
- Testing
- Visit 1: Clinical exam and questionnaires, Visit 1: Respiratory physiology, Visit 1: Inflammometry
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Respiratory Disease
Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for the Characterization of Volatolome in Clinical Studies
A major obstacle in precision medicine is the unavailability of biomarkers that are easy to access, non-invasive, measurable with high-performance techniques, fast, easy to use, reproducible, inexpensive and easily deployable on…
- Trial name
- VOC-COMPARE (NCT06020521)
- Testing
- Three spectrometry differents technics
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hopital Foch