Clinical trials: Personalized Medicine
Healthy Volunteers, Liver Cancer
4D-MRI for Precision Medicine
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI).
- Conditions
- Healthy Volunteers, Liver Cancer, Lung Cancer
- Trial name
- NCT04657042
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Schizophrenia
Program for the Introduction Into Clinical Practice of the Principles of Personalized and Preventive Medicine Based on the Isolation of Gene Polymorphism in Schizophrenia in People of the Kazakh Ethnic Group
This is a GWAS study that aims to identify possible candidate genes associate to schizophrenia by exploring single nucleotide polymorphism (SNP) in a group of schizophrenia, in the Kazakh population.
- Trial name
- NCT05090644
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
IVF
Opt-IVF Multi-center Trial 2 Including All Protocols
A multi-center randomized clinical trial is proposed to study the effectiveness of the advanced decision support tool Opt-IVF for ALL PROTOCOLS in reducing medication, testing, and improving outcomes.
- Trial name
- NCT05981898
- Testing
- OPTIVF dosage, traditional Dosage
- Where
- India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Stochastic Research Technologies LLC
PARKINSON DISEASE (Disorder), Alzheimer s Disease
Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease.
In recent decades, advances in medicine have significantly improved both quality of life and life expectancy. However, these positive effects are also associated with a considerable increase in the prevalence of age-related…
- Conditions
- PARKINSON DISEASE (Disorder), Alzheimer s Disease, Diabete Type 2
- Trial name
- NEUROTECHNO (NCT07467460)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Individuality, Healthy Subjects
Milieu Intérieur Collection - Genetic & Environmental Determinants Of Immune Phenotype Variance
The purpose of this study is to assess the determinants of immunologic variance within the general healthy population.
- Trial name
- MI (NCT03905993)
- Volunteers
- 956 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma
Liver Cancer and Immunotherapy in the Liquid Biopsy Era
The goal of this prospective clinical trial is to identify a predictive biomarker in patients with advanced HCC (stage B and C) using a combinatorial approach of the liquid biopsy.
- Conditions
- Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma, BCLC Stage C Hepatocellular Carcinoma, Immune Checkpoint Inhibitor
- Trial name
- LILIPSY (NCT05810402)
- Testing
- Liquid Biopsy
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Hereditary Cancer Syndromes
Increasing Uptake of Cascade Testing in Families With Familial Cancer Syndromes: A Randomized Controlled Trial of a Registry-aided Model.
The purpose of this study is to compare the uptake rates of a patient-initiated model of cascade testing with a registry-aided model amongst relatives of patients identified to have a particular cancer predisposition gene.
- Trial name
- NCT07626814
- Testing
- Proband-dependent approach, Combination of the proband-dependent approach with additional registry-aided testing reminders
- Where
- Singapore
- Volunteers
- 545 people, healthy volunteers welcome
- Sponsor
- National Cancer Centre, Singapore
Healthy
Effect of Pharmacist Initiated Recommendations On Prescribing For Participants In the Senior MEDS Personalized Medication Review
What are the demographic and medication utilization characteristics of participants in the Senior MEDS personalized medication review compared to other community-dwelling elderly, what is the level of satisfaction with Senior…
- Trial name
- NCT00205140
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Macular Degeneration
MacuTest Website for Personalized AMD Risk Prediction and Prevention
LEHA team of Bordeaux University has developed an Age-related Macular Degeneration (AMD) prediction algorithm (taking into account age, 49 genetic variants, the presence of early retinal abnormalities, tobacco consumption, food…
- Trial name
- MACUTEST (NCT05675917)
- Testing
- MacuTest platform
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Rheumatoid Arthritis
PRECISion medicinE Across the Disease Continuum to Prevent and Treat Rheumatoid Arthritis
The study will recruit patients referred to the Rheumatology Out-patient departments. Patients will be recruited to the study or control groups (healthy or disease controls who will be age and sex-matched) as needed.
- Trial name
- PRECISE-RA (NCT04482335)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Healthy Adults, Genetic Predisposition to Disease
Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force
The MilSeq Project is a nonrandomized, prospective pilot study of whole exome sequencing (WES) in the U.S. Air Force. The purpose of this study is to explore the implementation of WES into clinical medical care in the military…
- Trial name
- MilSeq (NCT03276637)
- Testing
- Whole exome sequencing
- Where
- 3 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mild Traumatic Brain Injury
Behavioral Profile Matching: A Precision Medicine Approach to Concussion Rehabilitation
At least 1 in 5 people who sustain a concussion will have persistent symptoms and difficulties with daily activities. The researchers have identified two unhelpful coping styles following a concussion - avoidance and endurance.
- Trial name
- NCT03972579
- Testing
- Graded exposure therapy, Pacing + mindfulness
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes, Congenital Heart Disease
The Roles of Trust and Respect in Patient Reactions to Race-based and Personalized Medicine Vignettes: An Experimental Study
Background: Genetic research has implications for drug development and marketing. Race-based medicine may be able to provide specific treatment for populations with increased disease-specific morbidity and mortality.
- Conditions
- Diabetes, Congenital Heart Disease, Hypertension
- Trial name
- NCT00911833
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)