Clinical trials: Persons With Psychiatric Disorders
Major Depressive Disorder, Mild Neurocognitive Disorder
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with…
- Conditions
- Major Depressive Disorder, Mild Neurocognitive Disorder, HIV
- Trial name
- NCT06705478
- Testing
- Pramipexole ER, Escitalopram
- Where
- 41 sites in United States, Botswana and 12 more
- Volunteers
- 186 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis
Current evidence suggests that cigarette smoke increases disease progression in people with multiple sclerosis (PwMS) and worsen their symptoms. 70% of PwMS report sleep disturbances that negatively affects their quality of life.
- Trial name
- Smoke-MS (NCT05046535)
- Testing
- Sleep quality and physical activity, Nicotine dependence, Nicotine and cotinine serum levels
- Where
- Jordan
- Volunteers
- 72 people
- Sponsor
- University of Jordan
Depression, Anxiety Disorders
Impact of a Mental Health Support Program on of Medical Residents' Stigmatization Towards People With Lived Experience
The program, called the Mental Health Practice Support Program, is designed to teach new tools and skills for working with patients with mental health concerns in a family practice setting.
- Trial name
- NCT05057026
- Testing
- Training Program Adult Mental Health Practice Support Program
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Bianca Horner
Hyperkinetic Disorder, Depressive Disorder
Mindfulness and Relaxation Interventions in Individual Psychotherapies for Children and Adolescents
The study 'Mindfulness and Relaxation interventions in Individual Training Psychotherapies for Children and Adolescents' (MARS-CA) aims to examine the effects of short session-introducing interventions with mindfulness elements…
- Conditions
- Hyperkinetic Disorder, Depressive Disorder, Anxiety Disorder
- Trial name
- MARS-CA (NCT04034576)
- Testing
- Cognitive behavior therapy of trainee therapists
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Heidelberg University
Autism Spectrum Disorder (ASD), Relative (Related Person)
Developing an Intervention Facilitating the Use of Eye Contact in Adults With Autism
The aim of this study is to develop a methodological intervention for adults with autism that will help them reduce problems arising from eye contact.
- Conditions
- Autism Spectrum Disorder (ASD), Relative (Related Person), Care Giver
- Trial name
- NCT06924008
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Mental Health Conditions, Developmental Disability
Evaluation of Telehealth Services on Mental Health Outcomes for People With Intellectual and Developmental Disabilities
Roughly 40% of those with intellectual and developmental disabilities (IDD) have mental health needs, which is twice the national average.
- Trial name
- NCT05336955
- Testing
- Intake and quarterly assessment:, Consultation & coping skills coaching:, 24-hour urgent crisis response and intervention:
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- University of New Hampshire
Psychiatric Disorder
Familial and Functional Study of Genetic Variants Identified in People With Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder or Resistant Depression
Genetic analyses conducted on patient with psychiatric disorders assessed at the expert centres resulted in the identific action of genetic variants associated with psychiatric disorders (Courtois, 2020).
- Trial name
- GENI (NCT05480826)
- Testing
- study of the transmission of genetic variants
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Depression, Major Depressive Disorder
eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk
This pilot randomized controlled trial seeks: (1) to determine the preliminary efficacy of our modernized collaborative care intervention for depression in improving the diabetes risk markers of hemoglobin A1c and insulin…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT04437485
- Testing
- Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Indiana University
COPD (Chronic Obstructive Pulmonary Disease)
Internet-Based Cognitive Behavioral Therapy and Educational Program for People Living With Chronic Obstructive Pulmonary Disease (COPD)
The goal of this clinical trial is to learn if an internet-based cognitive behavioral therapy (CBT) and education program can help improve mental health, disease knowledge, and quality of life in adults with chronic obstructive…
- Trial name
- COPD BALANCE (NCT06891677)
- Testing
- Internet-Based Cognitive Behavioral Therapy (CBT) with ACT and COPD Education
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Jonas Agholme
Personality Disorders
The Effectiveness of a Creative Arts en Psychomotor Therapy Intervention for People With Personality Disorders. From Negative Thinking to Positive Acting.
Mental health consists of the absence of mental disorders and the presence of mental well-being. However; mental health care currently focuses mainly on mental disorders and less on promoting mental well-being.
- Trial name
- NDPD (NCT06219122)
- Testing
- Creative arts and psychomotor therapies intervention for people with personality disorders
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- Suzanne Haeyen
Alzheimer Disease or Associated Disorder
Evaluation of the Effects of Serious Cognitive Games on a Digital Tactile Table for Elderly People with Alzheimer's Disease or Related Disorders
Alzheimer's disease and related disorders are chronic, progressive diseases that have a major impact on the lives of sufferers and their families.
- Trial name
- NCT06781645
- Testing
- The system involves a digital table with a tactile and interactive surface, providing several play areas. It simulates a village and offers different types of serious cognitive games: semantic memory
- Volunteers
- 46 people
- Sponsor
- RIVAGES
Vision Disorders, Stress, Psychological
Effectiveness of a Cognitive-behavioral Program of Coping With Psychological Stress in People With Retinitis Pigmentosa
The aim of this study is to evaluate the efficacy of cognitive - behavioral therapy for the control of psychopathological stress and the disease of people with Retinitis Pigmentosa (RP).
- Conditions
- Vision Disorders, Stress, Psychological, Psychopathy, Self Efficacy
- Trial name
- RCT (NCT03368027)
- Testing
- A cognitive-behavioral intervention program, Standard intervention
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Schizophrenia, Schizoaffective Disorder
Reducing Internalized Stigma in People With Serious Mental Illness
The purpose of this study is to determine if Ending Self-Stigma (ESS), a 9-session group intervention designed to assist veterans with serious mental illness to develop skills (SMI) to effectively cope with stigma and minimize…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression With Psychotic Features
- Trial name
- ESS (NCT01259427)
- Testing
- Ending Self Stigma (ESS), Health and Wellness Group
- Where
- 3 sites in United States
- Volunteers
- 252 people
- Sponsor
- VA Office of Research and Development
Dementia, Pain
Aggression Prevention Training for Caregivers of Persons With Dementia (APT)
This study will evaluate whether a home-based targeted education and skill training (Aggression Prevention Training or APT) will reduce aggression in persons with dementia (PWD) and pain/pain-related features more than usual care…
- Conditions
- Dementia, Pain, Alzheimer's Disease, Aggression
- Trial name
- APT (NCT02380703)
- Testing
- Aggression Prevention Training (APT), Enhanced Usual Primary Care (EU-PC)
- Volunteers
- 239 people
- Sponsor
- Baylor College of Medicine
Schizophrenia
A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia
An exploratory, double-arm, 4-week study to explore the feasibility and acceptability of abbreviated treatment with CT-156 for people with Schizophrenia.
- Trial name
- NCT06136936
- Testing
- CT-156-C-001
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Click Therapeutics, Inc.
Severe Mental Illness
Physical Activity for People With Behavioral Diagnoses
Our aims are to 1) test that our intervention that can be measured with high fidelity. 2) determine the feasibility of the intervention including recruitment, procedures, measures, intervention acceptability and resources .
- Trial name
- NCT05041634
- Testing
- IHOPE
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Oklahoma
Alzheimer's Disease, Capacity to Consent to Treatment
Capacity Assessment in Persons With Alzheimer's Disease
The purpose of this study is to assess decision-making capacity in persons with Alzheimer's disease. First, our goal is to validate four French capacity assessment tools for persons with Alzheimer's Disease : a French version of…
- Conditions
- Alzheimer's Disease, Capacity to Consent to Treatment, Capacity to Vote, Capacity to Design a Proxy
- Trial name
- MACAP (NCT01190800)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in people with HIV who are…
- Trial name
- PRISM (NCT07756736)
- Testing
- Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicky Mehtani, MD, MPH
Suspected Chronic Traumatic Encephalopathy (CTE) or Traumatic Encephalopathy Syndrome (TES), Suspected Alzheimer's Disease (AD)
FDDNP Protocol for Visualizing Brain Proteinopathies to Assist in the Diagnosis of Persons With Suspected CTE and AD
The primary objective of this study is to demonstrate the safety and efficacy of positron emission tomography (PET) imaging with a radioactive compound called [F-18]FDDNP in subjects with suspected Alzheimer's disease or…
- Trial name
- FDDNP (NCT04311281)
- Testing
- [F-18]FDDNP-PET
- Sponsor
- University of California, Los Angeles
HIV/AIDS, Cardiovascular Risk Factors
Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV
"Healing our Minds and Bodies" (HHMB) uses a a hybrid type II effectiveness/implementation study design to increase both patient and organizational readiness to address trauma and CVD risk among African American and Latino…
- Conditions
- HIV/AIDS, Cardiovascular Risk Factors, Trauma, Psychological
- Trial name
- HHMB (NCT04025463)
- Testing
- HHMB
- Where
- 2 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
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