Clinical trials: Perthes Disease
Necrosis
Treatment of Osteonecrosis of the Femoral Head by Bone Marrow Transplantation
Aseptic non traumatic osteonecrosis (ON) is a painful disorder of the hip which often leads, in its final stage, to femoral head collapse and subsequent total hip replacement.
- Trial name
- NCT00821470
- Testing
- core decompression, Bone marrow implantation into the necrotic lesion
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Erasme University Hospital
Osteoarthritis, Avascular Necrosis
Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient Population
Evaluate E1 wear, Clinical Performance of E1 liner in THA in Korean Patient Population
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- E1Hip (NCT02087449)
- Testing
- E1-Hip Bearing
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Osteonecrosis of the Femoral Head
PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells
The purpose of this study is to analyze the safety and feasibility of direct administration intrafemoral mesenchymal stem cells (MSCs) in vitro expanded autologous treatment of patients with femoral osteonecrosis.
- Trial name
- CSM/ON/2011 (NCT01700920)
- Testing
- bone marrow aspirate
- Where
- Spain
- Volunteers
- 3 people
- Sponsor
- Red de Terapia Celular
Osteonecrosis of the Femoral Head
RAB001（LLP2A-Ale） in Healthy Subjects
This trial is a single center, randomized, double-blind, placebo-controlled dose escalation study aimed at examining the safety, tolerability, and pharmacokinetics/pharmacodynamics of single and multiple injections of RAB001 in…
- Trial name
- LLP2A-Ale (NCT07545018)
- Testing
- RAB001 400 μg/kg group, RAB001 750 μg/kg group, Normal saline
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Hip Osteoarthritis, Osteonecrosis of the Femoral Head
Comparison of the Efficacy of Pericapsular Nerve Group Block Alone Versus Pericapsular Nerve Group Block Combined With Superior Cluneal and Superior Gluteal Nerve Blocks in Patients Undergoing Hip Surgery
In the clinic, total hip arthroplasty is a frequently performed surgical procedure that often results in moderate to severe postoperative pain.
- Conditions
- Hip Osteoarthritis, Osteonecrosis of the Femoral Head, Avascular Necrosis of Femur Head, Dysplasia of Hip Joint
- Trial name
- NCT07255768
- Testing
- 15 ml Bupivacaine Hcl 0.25% injection, 20 mL bupivacaine 0.25% injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Avascular Necrosis of Femur Head
Mesenchymal Stem Cells in Osteonecrosis of the Femoral Head
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in osteonecrosis of the femoral head in comparison to the standard treatment of isolated core decompression.
- Trial name
- NCT01605383
- Testing
- XCEL-MT-OSTEO-ALPHA, Standard treatment
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Banc de Sang i Teixits
Osteonecrosis
Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head
Femoral head avascular necrosis is a relatively common disease (10,000 - 20,000 yearly new United States of America cases) characterized by ischemic cell necrosis in a hip proximal epiphysis area frequently requiring total Hip…
- Trial name
- AVN-13 (NCT01892514)
- Testing
- core decompression
- Where
- 3 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteonecrosis, Avascular Necrosis
Effect of HBOT on Femoral Head Avascular Necrosis (AVN)
The primary objective of this study is to determine whether the Hyperbaric Oxygen Therapy (HBOT) conducted under the Marx Protocol improves pain outcomes when combined with core decompression with autologous bone marrow aspirate…
- Trial name
- NCT06931301
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Yale University
Non Traumatic Osteonecrosis of the Femoral Head (Hip)
Controlled Study of Stage 3 Osteonecrosis Treatment by Bone Marrow
In stage 3 Osteonecrosis (ON) of the femoral head, a beneficial effect of bone marrow grafting was reported with a reduction of the functional evolution and the necessity of a total prosthesis placement in a non-controlled…
- Trial name
- NCT01544712
- Testing
- core decompression with autologous bone marrow implantation, core decompression of the femoral head
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Osteochondritis of the Femoral Head
Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head
Mesenchymal Stem Cells (MSCs) have been shown to have immunosuppressive and repairing properties. Bone marrow mononuclear cells (BMMNCs) have revascularization properties and complimentary effects to MSCs.
- Trial name
- NCT00813267
- Testing
- mesenchymal stem cell infusion, bone marrow mononuclear cell infusion
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Jianming Tan
Osteonecrosis of the Femoral Head
Screening for Biomarkers of Osteonecrosis of the Femoral Head
Osteonecrosis of the femoral head (ONFH) presents a rapidly progressive natural disease course. Femoral head collapse may occur within two years, ultimately necessitating total hip arthroplasty and imposing a heavy medical and…
- Trial name
- NCT07545616
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Vertebral Fracture, Osteonecrosis
Vertebral Fracture and Osteonecrosis Associated With High-dose Glucocorticoid
Osteoporotic vertebral fracture (VF) and osteonecrosis of the femoral head (OFH) are major concerns in patients with systemic rheumatic diseases treated with high-dose glucocorticoids (GCs).
- Conditions
- Vertebral Fracture, Osteonecrosis, Rheumatic Diseases
- Trial name
- NCT00679978
- Volunteers
- 60 people
- Sponsor
- Saitama Medical University
Osteonecrosis
Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral Head
The purpose of this study is to determine if Ixmyelocel-T grafting with demineralized bone matrix bound in autologous plasma after core decompression surgery is superior to core decompression with demineralized bone matrix bound…
- Trial name
- ON-CORE (NCT00505219)
- Testing
- Ixmyelocel-T, Standard of Care Only
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Vericel Corporation
Legg-Calvé-Perthes Disease
WOMAC Hip Score in Children and Adolescents With Perthes Disease
Patient oriented clinical outcomes have increased in use and popularity and provide a comprehensive assessment of the level of symptoms and function experienced by a patient.
- Trial name
- WOMAC (NCT02795494)
- Testing
- WOMAC questionnaire at baseline, ASK-P questionnaire at baseline, WOMAC questionnaire at 2 weeks
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- British Columbia Children's Hospital
Osteonecrosis of the Femoral Head
Study on Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral Head
Non-traumatic osteonecrosis is a painful disorder of the hip characterized by a necrosis of the osteomedullary tissue, which leads to subchondral bone collapse and joint destruction.
- Trial name
- NCT01529008
- Testing
- Core decompression/PREOB® implantation
- Volunteers
- 68 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Osteonecrosis of the Femoral Head, Avascular Necrosis of the Femoral Head
Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis
Osteonecrosis of the femoral head (ONFH) is a debilitating musculoskeletal disease that is characterized by localized death of bone cells and associated cellular elements within the subchondral bone.
- Trial name
- BATON (NCT06123481)
- Testing
- Core Decompression, Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate
- Where
- 10 sites in United States
- Volunteers
- 192 people
- Sponsor
- Johns Hopkins University
Osteoarthritis, Post-traumatic Arthritis
A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement
This post-market clinical follow-up study was designed to compare hip replacement outcomes of the European Hip against 3 controls (Omniflex, Zweymuller, and Spotorno), however Omniflex did not end up being used.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders, Avascular Necrosis
- Trial name
- NCT00208468
- Testing
- European Hip, Zweymüller, CLS Spotorno
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 317 people
- Sponsor
- DePuy International
Osteonecrosis
Core Decompression With or Without Cement Packing for ONFH
Osteonecrosis of the femoral head (ONFH) is difficult to treat as collapse frequently occurs after core decompression (CD). This may be due to the failure to provide structural support during revascularization and healing.
- Trial name
- NCT04233125
- Testing
- Core Decompression, PMMA augmentation
- Volunteers
- 37 people
- Sponsor
- University of Minnesota
Predictors of Osteonecrosis of the Femoral Head After Treatment of the Dislocated Hip
Predictive Factors for the Development of Osteonecrosis After the Treatment of the Developmental Dislocated Hip
Several risk factors for the development of osteonecrosis of the femoral head following treatment of developmental dislocated hip have been reported.
- Trial name
- NCT01133938
- Where
- Austria
- Volunteers
- 79 people
- Sponsor
- Orthopedic Hospital Vienna Speising