Clinical trials: Pervasive Development Disorders
Autism Spectrum Disorder, High-functioning Autism
Neuralized1 and RGS14 Genes
Autism is a broad spectrum neurodevelopmental disease. Some individuals with ADS by high cognitive functions are diagnosed with High Functioning Autism (HFA).
- Conditions
- Autism Spectrum Disorder, High-functioning Autism, Healthy
- Trial name
- NCT04865198
- Testing
- Neurl1 gene expression, RGS14 gene expression
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Autism Spectrum Disorder, Parent-Child Relations
Pilot Testing of a Mobile Phone App-based Intervention for Parents of Children With Autism Spectrum Disorder (ASD)
The objective of this study is to conduct a pilot randomised controlled trial (RCT) evaluating the feasibility, acceptability, and preliminary efficacy of a 6-week mobile app-based intervention in empowering and supporting…
- Trial name
- NCT05927207
- Testing
- TRIP
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
ASD
Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD
The incidence of autism spectrum disorders is increasing, about 1 / 36. Neural cadherin (NCAD) is closely related to synaptic structure and function.
- Trial name
- NCT07400484
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Chen Li
Autism Spectrum Disorders
A Study of a Developmental,Individual-Difference,Relationship-Bases/Floortime Intervention for Children With Autistic
Thirty eight autistic spectrum disorder children age 2-6 years recruited into the study. The new treatment intervention is based on the DIR Model. Parents will be coached at the start and then every 3-4 months for 1 year.
- Trial name
- DIR (NCT00954213)
- Testing
- DIR/Floortime parent intervention
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Parent-Child Relations, Meals
Parent-Mediated Intervention for Families With Children With Autism and Feeding Challenges
The goal is to pilot a parent-mediated intervention for feeding challenges in children with autism building on recent research and current successful models already being used.
- Conditions
- Parent-Child Relations, Meals, Autism Spectrum Disorder
- Trial name
- NCT03071120
- Testing
- Parent-Mediated Intervention
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Autism Spectrum Disorders
Emotion Regulation in Preschoolers With Autism and Their Parents
In the proposed study, the investigators would like to investigate the emotion regulation (ER) strategies children with Autism Spectrum Disorders (ASD) demonstrate, and the influence parents have on their children's ER.
- Trial name
- NCT01643720
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Communication Disorder, Childhood, Autism
Evaluating Georgia Part C Implementation Outcomes
This study aims to answer the question: What is the best way to help Early Intervention (EI) providers deliver high-quality services to children with communication delays for autism? The primary goal of this project is to examine…
- Trial name
- NCT07148258
- Testing
- Project ImPACT Training As Usual, Project ImPACT Training Plus Co-Production, Routine Project ImPACT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Autism Spectrum Disorder
Early, Objective Detection of Autism.
1- To test the hypothesis that using the SensoDetect Brainstem Evoked Response Audiometry (BERA) technology may be an effective support tool for pediatricians to detect autism.
- Trial name
- NCT06447285
- Testing
- SensoDetect BERA technology
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SensoDetect
Autistic Disorder
Proteomic Biomarker Tests in Blood Samples from Children with Autism Spectrum Disorder (ASD)
Behavioral testing is the gold standard for diagnosing autism spectrum disorder (ASD). These tests, including ADOS and ADI-R, are subjective, require trained staff to administer, are time-consuming, and can only be administered…
- Trial name
- NCT02168868
- Testing
- Blood draw, Stool Sample Collection, Urine Sample Collection
- Where
- Israel
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Benjamin Gesundheit
Autism Spectrum Disorder, Parental Stress
The Effect of a Micro-Appreciation Intervention (Three-Things Journal Application) on Caregiver Burden, Family Functioning, and Happiness Levels for Mothers of Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder in which individuals experience significant difficulties in social interaction, communication, and repetitive behaviors.
- Trial name
- NCT07124091
- Testing
- Positive Event Writing Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Autism Spectrum Disorder, Autism
Faecal Microbiota Analysis in Neurotypical and Autism Syndrome Disorder Siblings
This study aims to accurately characterise the gut microbiota composition of faeces of children with ASD and compare it with the gut microbiota composition of their neurotypical siblings.
- Trial name
- FAMILY (NCT05794620)
- Testing
- Stool sample
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- East Suffolk and North Essex NHS Foundation Trust
Psychotic Disorders, Autism Spectrum Disorder
EEG Microstates Across At-Risk Mental States
The goal of this observational study is to compare subjects with at-risk-mental-state, early psychosis, schizophrenia, depression, and autism spectrum disorders, with healthy controls (N = 21 x 6).
- Conditions
- Psychotic Disorders, Autism Spectrum Disorder, Major Depressive Disorder, Schizophrenia
- Trial name
- DEMETER (NCT06045897)
- Testing
- EEG 64 channels, Polysomnography 19 electrodes, Light hypnosis
- Where
- France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Autism Spectrum Disorder, Depression
TMS for Adults With Autism and Depression
The goal of this proposal is to investigate whether a standard rTMS protocol for depression, including multiple sessions applied to left dorsolateral prefrontal cortex (DLPFC) results in reduction of depressive symptoms for adult…
- Conditions
- Autism Spectrum Disorder, Depression, Depressive Disorder, Major Depressive Disorder
- Trial name
- TAD (NCT02939560)
- Testing
- NeuroStar® TMS device (Neuronetics, Atlanta, GA)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Children With Autism Spectrum Disorder, Typical Developed Children
Investigating Handwriting Characteristics and Underlying Factor in Children With Autism Spectrum Disorder
The mechanism of the motor problem in children with autism spectrum disorder (ASD) in handwriting has been investigated in the following three aspects, including collecting dynamic handwriting performance, exploring the related…
- Trial name
- NCT06228885
- Testing
- handwriting experiment and motor ability test
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Autism Spectrum Disorder
Training Early Social Language in Autism
The aim of the study is to determine whether a targeted behavioral intervention can lead to both changes in early communication skills and in neural responses in toddlers and preschoolers with autism.
- Trial name
- TESLA (NCT03427138)
- Testing
- Jasper, Parent Education
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Autism Spectrum Disorder
Transcranial Magnetic Stimulation on Neural and Behavioral Facets of Social Cognition in Autism Spectrum Disorder
This study will evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in Autism Spectrum Disorder (ASD).
- Trial name
- TMSinASD (NCT04242355)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Autism Spectrum Disorder
Fit Families Program: Fundamental Motor Skill Intervention in Children With Autism Spectrum Disorders and Their Parents
The investigators aim to identify the effect of a 12-week fundamental motor skills (FMS) (e.g., throwing, catching, running) intervention on the active participation in physical recreation activities and a variety of other…
- Trial name
- NCT04612647
- Testing
- 12-week FMS Intervention, Physical Activities & Activity Booklets
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Brain Activity Flow Patterns Analysis Using Evoked Response Potentials in Youth With ADHD, Bipolar Disorder, or Autism Spectrum Disorders: A Preliminary Study
The study aims to evaluate whether or not an EEG (a type of brain scan) is useful in diagnosing youth with either ADHD, BPD, ASD.
- Conditions
- Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder
- Trial name
- NCT01506232
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autistic Disorder
Comparison of Applied Behavioral Analysis (ABA) Versus ABA and Risperidone
Hypotheses: 1. Preschool children with autism spectrum disorders (ASDs) who undergo ABA treatment only will demonstrate significantly better outcomes compared to an age and severity matched control group without ABA treatment. 2.
- Trial name
- NCT00374764
- Testing
- Risperidone, ABA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine