Clinical trials: Pervasive Development Disorders
Phelan-McDermid Syndrome, Autism Spectrum Disorder
Mapping the Phenotype in Adults With Phelan-McDermid Syndrome
The protocol aims to comprehensively define the phenotype of Phelan-McDermid Syndrome and to identify potential genetic factors, which may play a role in the variability of the disease's outcomes.
- Conditions
- Phelan-McDermid Syndrome, Autism Spectrum Disorder, Intellectual Disability
- Trial name
- NCT03426059
- Testing
- No Intervention
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- Boston Children's Hospital
Autism Spectrum Disorder
Tool for Evaluating the Effectiveness of the DENVER Protocol
Early remediation of the communicative and social difficulties of children with autism spectrum disorders (ASD) is central. However, from the age of 6-8 months, children with ASD show a lack of attention to social stimuli such as…
- Trial name
- FACECOM (NCT06253793)
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Autism
Study of Peer Relationships at School
The goal of this study is to compare the effects of two separate, manualized group interventions designed to improve social outcomes for young children with autism.
- Trial name
- HRSAII (NCT01011764)
- Testing
- SKILLS vs ENGAGE
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Health Resources and Services Administration (HRSA)
Autism Spectrum Disorder
Pivotal Response Treatment (PRT) Telemedicine
The purpose of this study is to evaluate the application of a modified version of PRT designed specifically as a parent-training model via telemedicine, with the goal of increasing access to empirically validated care.
- Trial name
- PRT (NCT03045263)
- Testing
- Pivotal Response Treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Autism Spectrum Disorder
Targeting Repetitive Behaviors in Autism Spectrum Disorder Via Transcranial Direct Current Stimulation
Repetitive behaviors (RBs) are a prevalent feature of Autism Spectrum Disorder (ASD). There are two groups of RBs: lower-order (e.g. motor stereotypies) and higher-order RBs (e.g.
- Trial name
- NCT06645587
- Testing
- Active HD-tDCS over pre-SMA, Active HD-tDCS over left DLPFC
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Autism Spectrum Disorder, Depression
Feasibility and Efficacy of rTMS in Depression in Patients With Autism Spectrum Disorder (ASD)
Depression is a common complication of Autism Spectrum Disorder (ASD): it is four times more prevalent in people with ASD than in the general population.
- Conditions
- Autism Spectrum Disorder, Depression, Major Depressive Episode (MDE)
- Trial name
- DEPASS'R (NCT07258914)
- Testing
- rTMS, rTMS treatment with intermittent Theta Burst (ITBS)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Hospital Center Guillaume Régnier
Autism, Autism Spectrum Disorder
Word Learning From Parentese in Autistic Children
The overall objective of this research is to determine whether parentese delivered in the video format (Aim 1) and in live interaction (Aim 2) facilitates novel word learning in autistic children and to investigate if there are…
- Conditions
- Autism, Autism Spectrum Disorder, Neurodevelopmental Disorders
- Trial name
- NCT06649916
- Testing
- Parentese Speech, Adult Registered Speech
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Autism Spectrum Disorder
Social Cognitive Development in Young Children With Autism
Through the development of a novel treatment targeting core Autism Spectrum Disorder (ASD) social deficits and studying the efficacy of this intervention, the investigators hope to provide a means for children with ASD to more…
- Trial name
- NCT01425918
- Testing
- Social Enhancement Intervention, Parent Education
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Autism Spectrum Disorder, Healthy
Investigating the Clinical Utility of the Oxford Virtual Autism Assessment Tool (OVAAT)
The goal of the study is to evaluate a new Autism Spectrum Disorder (ASD) diagnostic tool (Oxford Virtual Autism Assessment Tool (OVAAT)) to see whether it can: Be able to identify autistic traits Be able to distinguish between…
- Conditions
- Autism Spectrum Disorder, Healthy, Neurotypical
- Trial name
- NCT06582290
- Testing
- Oxford Virtual Autism Assessment Tool (OVAAT)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oxford Health NHS Foundation Trust
Autism
Using Serious Game Technology to Improve Sensitivity to Eye Gaze in Autism
The investigators hypothesize that this serious game (designed to provide a learning environment that maximizes opportunities for adolescents with autism to discover the functional utility of eye gaze) will improve sensitivity to…
- Trial name
- SAGA (NCT02968225)
- Testing
- Computer Game
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Penn State University
Autism Spectrum Disorder
Effectiveness of Parent-Mediated Intervention Combined With Positive Behavioral Support on Challenging Behaviors and Parenting Stress Among Children With Autism.
This study aims to evaluate the effectiveness of a parent-mediated intervention combined with Positive Behavioral Support (PBS) in reducing challenging behaviors among children with autism and decreasing parenting stress in South…
- Trial name
- NCT07570550
- Testing
- Parent-Mediated Intervention + Positive Behavioral Support (PMI + PBS)
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Islamia University of Bahawalpur
Pediatric Autism, Developmental Delay (Disorder)
Animal-Assisted Therapy in Pediatric Autism Spectrum Disorders
The purpose of this research is to evaluate the effect of animal-assisted therapy (AAT) on prosocial behavior and emotional regulation in children with developmental delay, behavioral concerns, or autism spectrum disorder.
- Conditions
- Pediatric Autism, Developmental Delay (Disorder), Behavioral Concerns
- Trial name
- NCT06687850
- Testing
- animal assisted therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Arkansas, Fayetteville
Autism Spectrum Disorder, Autism
Adia Med of Winter Park LLC Autism Spectrum Disorder Research Study
This 12-month study tests whether AdiaVita (umbilical cord blood-derived stem cells and exosomes) plus glutathione improves autism symptoms more than glutathione alone in children ages 3-12.
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autism Spectrum Disorder (ASD)
- Trial name
- NCT07304440
- Testing
- Umbilical Cord Blood-Derived Stem Cells and Exosomes, Glutathione
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Adia Med of Winter Park LLC
Autism Spectrum Disorders
Neural and Behavioral Effects of Oxytocin in Autism Spectrum Disorders
The current trial aims to explore the neural and behavioral effects of oxytocin in autism spectrum disorders (ASD). Oxytocin is a nonapeptide produced by the paraventricular and supraoptic nuclei of the hypothalamus and is known…
- Trial name
- NCT02940574
- Testing
- Syntocinon (Oxytocin)
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Agitation in Adolescents and Young Adults With ASD
INP105 Proof-of-concept Study for the Acute Treatment of Agitation in Adolescents and Young Adults With ASD
This is a Phase 2a, proof-of concept, 2-way, 2-period crossover, double-blind study to evaluate the safety and efficacy of INP105 as an acute treatment versus placebo in adolescents and young adults with autism spectrum disorder…
- Trial name
- CALM 201 (NCT05163717)
- Testing
- INP105
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Impel Pharmaceuticals
Social Skill Training Group
Establishment of Social Skills Training Group in Adults With Autism Spectrum Disorder and Effectiveness Analysis
This project aims to examine the effectiveness of social skill training group in adults with autism spectrum disorders.
- Trial name
- NCT05054829
- Testing
- PEERS®: program for the education and enrichment of relational skills
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Autistic Disorder
Sapropterin as a Treatment for Autistic Disorder
This study is intended to provide a definitive test of the hypothesis that elevating sapropterin (tetrahydrobiopterin, a cofactor for several key brain enzymes)concentrations in the CNS will result in measurable improvements in…
- Trial name
- NCT00850070
- Testing
- sapropterin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Children's Health Council
Fetal Growth Restriction
A Randomized Air Filter Intervention Study of Air Pollution and Fetal Growth in a Highly Polluted Community
The purpose of this study is to use an air filter intervention to evaluate the relationship between particulate matter air pollution exposure during pregnancy and fetal growth.
- Trial name
- NCT01741051
- Testing
- HEPA Filter
- Where
- Mongolia
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Autistic Disorders Spectrum
The Efficacy of Robot-enhanced Therapy for Children With Autism Spectrum Disorders
This trial will test the efficacy of robot-enhanced interventions for developing social skills in children with Autism Spectrum Disorders (ASD).
- Trial name
- DREAM-RCT (NCT03323931)
- Testing
- (2) robot--enhanced intervention, (1) discrete trial training / cognitive-behavior therapy
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Babes-Bolyai University
Autism Spectrum Disorder
Improving Social Communication in Individuals With ASD Using AI
The purpose of this study is to identify whether researched and commonly used face-to-face interventions can be effectively implemented through artificial intelligence (AI) using an application on the phone or computer.
- Trial name
- NCT05987774
- Testing
- AI Modules for Improving Social Communication
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- Stanford University
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