Clinical trials: Pervasive Development Disorders
Autistic Disorder, Pervasive Developmental Disorder
Advanced Grandparental Age as a Risk Factor for Autism
The Division of Medical Genetics at the University of Mississippi Medical Center is recruiting parents of children with a pervasive developmental disorder (including autism, autistic spectrum disorder, PDD-NOS, Asperger syndrome…
- Conditions
- Autistic Disorder, Pervasive Developmental Disorder, Asperger Syndrome, Childhood Disintegrative Disorder
- Trial name
- NCT00464477
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Mississippi Medical Center
Autism
Testing the Efficacy of 100mg Vitamin-B6 Daily for Sensory Reactivity in Autism
This clinical trial aims to explore the effect of Vitamin B6 supplementation on anxiety sensory hyperreactivity in autistic adults.
- Trial name
- NCT06234501
- Testing
- Pyridoxal 5'-Phosphate (100 mg)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Reading
ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder (ASD)
Biomarkers of ASD/ADHD and Factors Affecting Anxiety and Depression in Children and Young Adults
The PUREMIND OS1/OS2 study is a multinational, prospective, longitudinal observational study designed to identify early neurophysiological, biological, environmental, and psychosocial markers associated with neurodevelopmental…
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder (ASD), Developmental Coordination Disorder (DCD)
- Trial name
- PUREMIND-OS (NCT07570381)
- Where
- United Kingdom
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Implementation Research
Implementation of Naturalistic Developmental Behavioral Intervention (NDBI) Through Coaching Caregivers of Young Autistic Children
Naturalistic developmental behavioral interventions (NDBIs) are a newer class of evidence-based interventions for young autistic children to promote their positive developmental or behavioral outcomes.
- Trial name
- NCT06923553
- Testing
- NDBIs
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Autism Spectrum Disorder
Virtual Reality-Based Self-Modeling Intervention for Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication and interaction, as well as restricted and repetitive behaviors.
- Trial name
- OSB-VR (NCT07505901)
- Testing
- Virtual Reality Self-Modeling Training, Conventional Behavioral Rehabilitation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Inonu University
Autistic Children With Sensory Processing Abnormalities
Comparison of Effectiveness of Home Based Sensory Interventions Along With Standard Therapy Versus Standard Therapy Alone in Autistic Children With Sensory Processing Abnormalities
Around 69-95% of children with Autistic Spectrum Disorder are known to have sensory processing abnormalities .Tackling these problems would help in better quality of life, both for the parents and the children.
- Trial name
- NCT02491645
- Testing
- Sensory interventions
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Autism Spectrum Disorder
AI-Based Reflective Parenting Simulation for Parents of Autistic Children
This randomized controlled trial evaluates an AI-based parental simulation designed to support reflective parenting, emotional regulation, and parent-child communication among parents of autistic children aged 3 to 12 years.
- Trial name
- NCT07687381
- Testing
- AI-Based Reflective Parenting Simulation
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Autism Spectrum Disorder
Comparative Efficacy of Self-directed & Therapist-assisted Telehealth Parent Training Intervention for Children With ASD
The specific objectives of this project are to conduct a randomized control trial to examine the effect of a novel, telehealth parent training intervention for children with autism spectrum disorder (ASD), ImPACT Online, on…
- Trial name
- NCT02721381
- Testing
- ImPACT Online
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Michigan State University
Autism
Centering Autistic Perspectives in Behavioral Intervention Discussions
The Centering Autistic Perspectives for Behavioral Interventions Discussions (CAPBID) PCORI Science of Engagement Award will examine different community engagement approaches for bringing together autistic people, Applied…
- Trial name
- CAPBID SoE (NCT07165522)
- Testing
- Transformative and Restorative Engagement Circle (TREC), Stakeholder Engagement in quEstion Development and prioritization (SEED)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Drexel University
Autism Spectrum Disorder
Cognoa Autism Spectrum Disorder (ASD) Digital Therapeutic Engagement and Usability Study
Cognoa will measure usability, engagement with the device, and changes in parent-reported socialization during a 4-week period of intervention at home with the Cognoa ASD therapeutic device.
- Trial name
- NCT04326231
- Testing
- Usability assessment of Cognoa ASD Therapeutic Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cognoa, Inc.
Autism Spectrum Disorder, Developmental Delay
Improving Autism Screening With Brain-Related miRNA
The goal of this project is to identify specific miRNAs that are increased or decreased in the saliva of children with developmental delay and are useful for screening toddlers for ASD.
- Trial name
- NCT02712853
- Testing
- Saliva collection, Vineland Adaptive Behavior Scale-II Assessment
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Intellectual Disability, Cerebral Palsy
Oral Health Promotion Among Preschool Children With Special Needs
Establishing good oral health-related habit is challenging among younger children, especially for preschool children with special needs, as they have physical, mental, sensory, behavioural, emotional, and chronic medical…
- Conditions
- Intellectual Disability, Cerebral Palsy, Developmental Disorders, Developmental Delay
- Trial name
- NCT03522337
- Testing
- Visual pedagogy (social stories), Conventional leaflets
- Where
- China
- Volunteers
- 306 people
- Sponsor
- The University of Hong Kong
Autism Spectrum Disorder
Comprehensive Communication Intervention for Minimally Verbal Children With Autism
Overview The goal of Comprehensive Communication Intervention for Minimally Verbal Children with Autism is to conduct an efficacy study of a promising intervention to increase spoken language in preschool children who are…
- Trial name
- NCT02291172
- Testing
- Intervention JEP
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Autism Spectrum Disorder
Diagnostic Performance of Exome Sequencing in Autism Spectrum Disorders
Evaluation of the diagnostic performance of exome sequencing in a prospective series of patients with autism spectrum disorders (ASD).
- Trial name
- REDIA (NCT04043351)
- Testing
- blood test
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Sleep Problems
Assessment of the Pharmacokinetics of Circadin® in Children With Neurodevelopmental Disorders and Sleep Disturbances
There is increasing evidence that chronic sleep disorders in children with autism spectrum disorder (ASD), Angelman Syndrome (AS) and Smith-Magenis syndrome (SMS) are associated with disturbed melatonin secretion and melatonin…
- Trial name
- NCT01903681
- Testing
- Circadin 2 mg, Circadin 10 mg
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Developmental Disabilities, Autistic Spectrum Disorder
"Family-centered" Pediatric Rehabilitation Services in Children With Developmental Disabilities
Developmental disability is a severe chronic disabled condition caused by mental or physical impairments. Children with developmental disabilities may face life-long difficulties in motor functioning, self-care, condition…
- Trial name
- NCT02057809
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Chang Gung University
Autism Spectrum Disorder
Autism & Anesthetic Exposure Study
As anesthesia is often needed for childhood surgery and procedures, researchers have examined the potential effects of anesthesia on neurodevelopment.
- Trial name
- NCT03514498
- Testing
- Dental surgery
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Autism Spectrum Disorder
Intranasal Oxytocin for the Treatment of Children and Adolescents With Autism Spectrum Disorders (ASD)
We are studying an investigational drug called intranasal oxytocin (Syntocinon®). Syntocinon® has been approved by the U.S. Food and Drug Administration for use in helping women breastfeed, but it has not been approved for use in…
- Trial name
- OXY-R (NCT01908205)
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorder
Effect of Nutrition and Oral Hygiene Education Using Telehealth on Diet Diversity, Nutrition Literacy and Oral Hygiene Practices in Children With Autism: A Mixed-method Study
The goal of this interventional study is to assess the knowledge of caregivers of children with Autism Spectrum Disorder (ASD) regarding oral and nutritional health and the burdens they encounter in dealing and caring for these…
- Trial name
- NCT05860829
- Testing
- Educational
- Where
- 2 sites in Pakistan
- Volunteers
- 123 people
- Sponsor
- Dow University of Health Sciences
Autism, Autism Spectrum Disorder
Exploring Theatrical Expressive Tasks for Children With ASD
Autism Spectrum Disorder (ASD), according to the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders- V Edition (DSM-5), is a disorder involving (a) persistent deficits in social communication, social…
- Trial name
- NCT06468072
- Testing
- Expressivity protocol for children with autism, Expressivity protocol for non-autistic children
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
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