Clinical trials: Pharmacogenomic Testing
CDK4/6 Inhibitor, Breast Cancer
Pharmacogenomic and Circulating Biomarkers for CDK4/6 Inhibitors
The goal of this research study is to reduce adverse effects of anti-cancer medications known as kinase inhibitors, while preserving their therapeutic benefits. There have been major advances in the way cancers are treated.
- Conditions
- CDK4/6 Inhibitor, Breast Cancer, CYP3A4 Protein, Human, Drug Interaction
- Trial name
- NCT07100054
- Testing
- Whole gene sequencing, Drug-drug interaction analysis, Biomarker analysis
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Pharmacogenomics in Pulmonary Arterial Hypertension
Our goal is to determine clinically in Pulmonary Arterial Hypertension patients if associations exist between the efficacy and toxicity of sitaxsentan, bosentan, and ambrisentan and several gene polymorphisms in several key…
- Conditions
- Pulmonary Arterial Hypertension, Pulmonary Hypertension, PAH WHO Group I
- Trial name
- NCT00593905
- Testing
- Sitaxsentan, Bosentan, Ambrisentan
- Where
- United States
- Sponsor
- West Penn Allegheny Health System
Major Depressive Disorder (MDD)
Genomics Used to Improve DEpression Decisions
Evaluate the impact of GeneSight Psychotropic on response to psychotropic treatment as judged by the mean change in the 17-item Hamilton Depression (HAM-D17) score from baseline to end of Week 8 of the study.
- Trial name
- GUIDED (NCT02109939)
- Testing
- GeneSight Psychotropic
- Where
- 61 sites in United States
- Volunteers
- 1,398 people
- Sponsor
- Assurex Health Inc.
DPYD Gene Mutation, Gastrointestinal Cancer
Nudge Strategies for DPYD Testing in Patients With Gastrointestinal Cancers Treated With Fluoropyrimidines
5-fluorouracil and capecitabine, sometimes called 5-FU, fluoropyrimidines, or Xeloda are a type of chemotherapy. Many people have side effects from these drugs like nausea, diarrhea, or blood problems.
- Conditions
- DPYD Gene Mutation, Gastrointestinal Cancer, Health Care Seeking Behavior
- Trial name
- DPYD Nudges (NCT06559462)
- Testing
- Focus Group, Discrete Choice
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pediatric Cancer
Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients
Pharmacogenomic (PGx) testing involves analyzing variants of genes associated with drug metabolism, transport and medication targets.
- Trial name
- NCT06744712
- Testing
- Pharmacogenomic Testing
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Wake Forest University Health Sciences
Gastroesophageal Reflux
Implementation of PPI Medication PGX Testing
Using genetic information about the individual to pick the right drug for the right disease at the right dose defines personalized medicine.
- Trial name
- PGX (NCT02794844)
- Testing
- Genotype Guided PPI Dosing
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Nemours Children's Clinic
Pain
Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes
Opioid analgesics are the most common postoperative pain medications used among dentists in the United States.Although these medications are highly effective in the postoperative dental pain management, not all patients optimally…
- Trial name
- NCT02932579
- Testing
- Pharmacogenomic Testing, Ibuprofen, hydroxycontin/acetominophen
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Pharmacogenomic Testing
VICE-MPRINT: Maternal and Pediatric Pharmacogenetics Survey
The field of pharmacogenetics has progressed from the discovery of genetic variants that cause variable function of drug metabolism enzymes to a cornerstone of clinical precision medicine.
- Trial name
- MPRINT (NCT05037305)
- Testing
- Educational video
- Where
- 2 sites in United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Heart Failure With Reduced Ejection Fraction
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics.
- Trial name
- NCT07490067
- Testing
- Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Cancer, Gastrointestinal Cancer
Evaluating Microarray Pharmacogenetic Testing in Cancer Patients
The purpose of this research is to evaluate the impact of a microarray PGx test on prescribing/dosing of drugs and cancer treatments in patients with cancer who are currently eligible for single-gene DPYD testing.
- Trial name
- NCT06489041
- Testing
- Pharmacogenomic Testing with the "Global Diversity Array with Enhanced PGx"
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wake Forest University Health Sciences
Pharmacogenomics and Cardiovascular Events
Pharmacogenomics and Effective Treatment With Clopidogrel
The aim of this biospecimen repository is to evaluate an individual's genotype, identify the variances, and understand how they relate to treatment with clopidogrel.
- Trial name
- NCT01611545
- Testing
- Pharmacogenomics
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Fall, Fall Accident
The Geriatric Emergency Department Pharmacologic Harm Prevention Project
The goal of this project is to determine whether pharmacogenomic testing (using participants' DNA) can help optimize medication prescribing and reduce side effects in older adults taking five or more medications.
- Conditions
- Fall, Fall Accident, Poly Pharmacy, Adverse Drug Events
- Trial name
- GREAT PHARM (NCT07216846)
- Testing
- DNA care pathway
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Florida Atlantic University
Pharmacogenetic Testing
Pilot of Preemptive Pharmacogenetics in Medically Underserved Patients
This is a pragmatic clinical trial of 100 patients who self-identify as black or Latino. Patients with active prescriptions for at least 3 medications and a medication change within the past 6-months will be recruited from the…
- Trial name
- NCT04630093
- Testing
- Panel-based pharmacogenetic genotyping
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Major Depressive Disorder
Pharmacogenomic Testing in Major Depressive Disorder
This is a two-arm double-blind prospective randomized controlled trial (RCT) to evaluate clinical impact of pharmacogenomic testing on the treatment of major depressive disorder.
- Trial name
- NCT03228953
- Testing
- Pharmacogenomic testing
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Columbia University
Major Depressive Disorder 1
Evaluation of Pharmacogenetic Testing In a Mental Health Population and Economic Outcomes
This is a non-randomized, single-case design of pharmacogenetic implementation in a mental health patient population of subjects taking antipsychotics and/or antidepressants.
- Trial name
- PGx-TIME (NCT02474680)
- Testing
- Pharmacogenetic testing
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Gastrointestinal Diseases
Utility of Pharmacogenomic Testing in Patients With Gastrointestinal Disorders
Researchers are trying to learn more about how individuals break down and process specific medications based on their genes. Pharmacogenomics (PGx) is a new, specialized field within individualized medicine.
- Trial name
- NCT05572593
- Testing
- Pharmacogenomics (PGx) genetic testing
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Mayo Clinic
Major Depressive Disorder
Comparative Effectiveness of Pharmacogenomics for Treatment of Depression
The overall goal of this study is to assess the effectiveness of a widely available and widely used combinatorial pharmacogenomic (PGx) test for the treatment of major depressive disorder.
- Trial name
- CEPIO-D (NCT03749629)
- Testing
- GeneSight Psychotropic test, Canadian Network for Mood and Anxiety Treatment (CANMAT) Best Practice Guidelines
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Massachusetts General Hospital
Adverse Drug Reaction (ADR)
Integrating Pediatric Pharmacogenomic Testing Into the Canadian Health Care System
This project addresses the problem of adverse drug reactions in the three most frequently prescribed therapeutic classes of drugs in children: antibiotics, analgesics, and mental health medications.
- Trial name
- NCT04249375
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University of British Columbia
Gastrointestinal Cancer, Head and Neck Cancer
The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care
Doctors leading this study hope to find out if giving study participants' genetic information to cancer care providers will help personalize chemotherapy dosing decisions and decrease common chemotherapy side effects.
- Conditions
- Gastrointestinal Cancer, Head and Neck Cancer, Dihydropyrimidine Dehydrogenase Deficiency, UGT1A1 Gene Mutation
- Trial name
- NCT04541381
- Testing
- Availability of clinical decision support based on pharmacogenomic results.
- Where
- United States
- Volunteers
- 860 people
- Sponsor
- University of Chicago
Hypercholesterolemia
Pharmacogenomic Informed Statin Prescribing
Statins are the most cost-effective medications to lower cholesterol and cardiovascular disease (CVD) risk. However, many patients at high-risk for CVD do not accept or adhere to statins.
- Trial name
- NCT06568601
- Testing
- Pharmacogenetic and polygenic risk testing, Active control
- Where
- 2 sites in United States
- Volunteers
- 410 people
- Sponsor
- VA Office of Research and Development