Clinical trials: Pharmacokinetics After Oral Intake
Healthy
Oral Bioavailability of GLPG0555 in Different Solid Formulations
The purpose of the study is to compare the pharmacokinetics of a solid capsule formulation of GLPG0555 with a nanosuspension, and to assess safety and tolerability of a single dose of GLPG0555.
- Trial name
- NCT01278095
- Testing
- GLPG0555 solid dispersion, GLPG0555 nanosuspension
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Safety After Oral Intake, Pharmacokinetics After Oral Intake
Bioavailability of Resveratrol From Vineatrol30 Extract Incorporated Into Micelles
To enhance the oral bioavailability of the antioxidants trans-resveratrol and trans-ε-viniferin from Vineatrol30 grapevine-shoot extract, the native powder was incorporated into micelles.
- Trial name
- NCT02944097
- Testing
- Vineatrol 30 native powder, Vineatrol 30 micelles
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Normal Healthy Volunteer, Safety After Oral Intake
A Research Study to Evaluate BLX-7006 in Healthy Adults
This study will test an oral medicine called BLX-7006, which acts like the hormone Glucagon-like Peptide-1 (GLP-1) to help control blood sugar and body weight. Current GLP-1 medicines are given by injection.
- Trial name
- NCT07140055
- Testing
- BLX-7006
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics
Safety After Oral Intake
Single Ascending Dose and Multiple Ascending Dose Evaluation of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MDI-2517 in Healthy Participants
The goal of this clinical trial is to learn if drug MDI2517 is safe and to learn more about its drug effects in healthy participants.
- Trial name
- NCT07220889
- Testing
- MDI-2517 800mg, MDI-2517 1600mg, MDI-2517 2400mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- MDI Therapeutics, Inc.
Safety After Oral Intake, Pharmacokinetics After Oral Intake
Comparison of Curcumin Bioavailability
The curcuminoids curcumin, demethoxycurcumin and bisdemethoxycurcumin can be found in the rhizome of turmeric (Curcuma longa). Curcumin is widespread used for colouring foods.
- Trial name
- NCT03530436
- Testing
- Native turmeric extract, Native turmeric extract with 7-9% volatile turmeric oils, Turmeric extract plus mixture of phytochemicals
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Healthy
Safety and Tolerability of CFTX-1554 in Healthy Subjects
The study will consist of 2 parts, i.e. a single ascending dose part with integrated food effect assessment and assessment of relative bioavailability (Part A), and a multiple ascending dose part (Part B).
- Trial name
- NCT05260658
- Testing
- CFTX-1554
- Where
- Netherlands
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Confo Therapeutics
Healthy
GLPG0259 Solid Formulation Bioavailability and Food Effect
The purpose of the study is to compare the pharmacokinetics of GLPG0259 as a solid dosage formulation (with and without food)and an oral solution, and to assess its safety and tolerability.
- Trial name
- NCT01024517
- Testing
- GLPG0259 solution, GLPG0259
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Safety After Oral Intake, Pharmacokinetics After Oral Intake
Oral Bioavailability and Bioactivity of Prenylflavonoids From Hops
The prenylflavonoids 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN) are secondary plant substances, almost exclusively found in hops (Humulus lupulus).
- Conditions
- Safety After Oral Intake, Pharmacokinetics After Oral Intake, Immune Cells Activity
- Trial name
- NCT03140397
- Testing
- 6-prenylnaringenin, 8-prenylnaringenin
- Where
- 2 sites in Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Safety After Oral Intake, Pharmacokinetics After Oral Intake
Absorption and Excretion Kinetics of the Bioactive Ingredients of Rice Bran Extract
The oral absorption and urinary excretion kinetics of the bioactive ingredients from rice bran (gamma-oryzanol, tocotrienols, tocopherols and ferulic acid esters) after incorporation into an oat porridge (oat porridge) compared…
- Trial name
- NCT02944084
- Testing
- Rice bran extract, Porridge in water, Porridge in milk
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Healthy Participants
A Study to Evaluate the Effect of Food on the Level of Circulating Elafibranor in Healthy Participants After Intake of a Single Tablet
This study will evaluate the effects of food on how much test drug is able to access the circulation and reach the target area (known as bioavailability).
- Trial name
- NCT05564208
- Testing
- elafibranor
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ipsen
Obesity & Overweight, Bariatric Surgery
Rosuvastatin and Losartan Pharmacokinetics After Bariatric Surgery
This prospective, open-label, non-randomized pharmacokinetic study will evaluate how Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy affect systemic exposure to single oral test doses of rosuvastatin and losartan.
- Conditions
- Obesity & Overweight, Bariatric Surgery, Pharmacokinetics After Oral Intake, Drug Absorption
- Trial name
- BARI-PK (NCT07748273)
- Testing
- Rosuvastatin, Losartan (Control)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Healthy
Oral Bioavailability of Two Solid Formulations of GLPG0259.
The purpose of the study is to evaluate the relative bioavailability of two solid oral formulations of GLPG0259 administered after a meal.
- Trial name
- NCT01322451
- Testing
- GLPG0259 fumarate, GLPG0259 free base
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Pharmacokinetics After Oral Intake
Pharmacokinetics of Sulopenem Etzadroxil Plus Probenecid in Adolescents
The goal of this clinical trial is to evaluate the use of sulopenem etzadroxil plus probenecid in adolescent patients being treated for bacterial infection.
- Trial name
- NCT07092813
- Testing
- sulopenem etzadroxil and probenecid
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Iterum Therapeutics, International Limited
Bioavailability and Pharmacokinetics, Safety After Oral Intake
Chrysin Bioavailability and Safety
This study seeks to evaluate and compare the pharmacokinetics of a micellar chrysin formulation (LipoMicel Chrysin) with that of a non-micellar chrysin formulation as well as a standard/unformulated chrysin supplement.
- Trial name
- NCT07066839
- Testing
- LipoMicel Chrysin, Non-Micellar Chrysin, Standard/Unformulated Chrysin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Isura
Safety of Native vs. Micellar 6-PN After Oral Intake, Pharmacokinetics of Native vs. Micellar 6-PN After Oral Intake
Increasing the Oral Bioavailability of 6-prenylnaringenin by Micellar Solubilization
Micellar encapsulation will be tested to increase the oral bioavailability in humans of 6-prenylnaringenin (6-PN) from hops (Humulus lupulus).
- Conditions
- Safety of Native vs. Micellar 6-PN After Oral Intake, Pharmacokinetics of Native vs. Micellar 6-PN After Oral Intake, PBMC Activity After Native vs. Micellar 6-PN Oral Intake
- Trial name
- NCT03286777
- Testing
- Native 6-prenylnaringenin, Micellar 6-prenylnaringenin
- Where
- 2 sites in Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Healthy Volunteer, Pharmacokinetics After Oral Intake
A Comparison of the Pharmacokinetic Properties of ARN-75039 Tablets With Excipients to Neat ARN-75039 in Hydroxypropyl Methylcellulose (HPMC) Capsules in Healthy Adult Participants Under Fed Conditions
ARN-75039-103 is a comparative, randomized, single-dose, cross-over study to assess the PK, safety, and tolerability of neat ARN-75039 in hydroxypropyl methylcellulose (HPMC) capsules compared with ARN-75039 with excipients in…
- Trial name
- NCT06911242
- Testing
- ARN-75039
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Arisan Therapeutics, Inc.
Healthy, Plasma Concentration Change of Quetiapine
Study to Evaluate the Effect of Food Intake on the Plasma Concentration Changes of Quetiapine After Oral Administration of FK949E in Healthy Volunteers
A study to evaluate the effect of food on the plasma concentration changes of quetiapine after oral administration of FK949E (extended release formulation of quetiapine) in healthy male subjects.
- Trial name
- NCT01871987
- Testing
- FK949E
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc