Clinical trials: Pharmacoresistant
Seizure
Study of Predictors of Response to Anti Epilepsy in Epilepsy
Pharmacoresistant epilepsy remains around 30% despite the development of 25 anti epileptic drugs. Of course, this can be explained by pharmacoresistant epileptic brain diseases, as exemplified by some genetic diseases.
- Trial name
- RESISTANT (NCT02883712)
- Where
- France
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Temporal Lobe Epilepsy
Electrical Brain Stimulation to Reduce Epileptic Seizures
OBJECTIVES: About 15% of patients suffering from focal epilepsy are refractory to available pharmacological treatments. Until now, the only hope for such patients has been the development of new pharmaceutical treatments or…
- Trial name
- NCT00344877
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Intractable Epilepsy
EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names
Neurophysiologic evaluation of disorders of consciousness (DOC) patients in intensive care unit include late auditory evoked potentials.
- Trial name
- EXPRESON-IN (NCT04810832)
- Testing
- Evoked related potentials
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier St Anne
Lennox-Gastaut Syndrome
Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot Study
Background: Lennox-Gastaut syndrome (LGS) is a severe childhood epileptic syndrome with high pharmacoresistance. The treatment outcomes are still unsatisfied.
- Trial name
- NCT02731300
- Testing
- tDCS
- Volunteers
- 22 people
- Sponsor
- Khon Kaen University
Pharmacoresistant Focal Epilepsies
Study of Interest of Stiripentol and Carbamazepine in the Treatment of Patients With Pharmacoresistant Focal Epilepsies
This is a monocentric, open-label clinical study, presenting a retrospective part and a prospective part, studying the data of patients with drug-resistant focal epilepsies and treated with the combination of stiripentol…
- Trial name
- NCT05419180
- Testing
- Stiripentol
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Biocodex
Major Depressive Disorder
Clinical, Cognitive and Neural Effects of Potentiation of ECT by rTMS in Treatment-Resistant Depression
Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression (TRD). However, due to response delay and cognitive impairment, ECT remains an imperfect treatment.
- Trial name
- STIMAGNECT2 (NCT06391723)
- Testing
- Active rTMS
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier du Rouvray
Depression
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study
This study is currently recruiting Veterans only. The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a…
- Trial name
- NCT04663841
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Interictal FDG-PET Hypometabolism Patterns
The Metabolic Characteristics in Sublobar Areas of PRE Based on FDG-PET Study
Epilepsy is a chronic brain disease that is caused by various factors and characterized by recurrent, episodic and temporary central nervous system dysfunction.
- Trial name
- NCT04642573
- Testing
- non interventional
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pharmacoresistant Neuropathic Pain
Analgesic Effect of Non Invasive Stimulation : Comparison of rTMS and tDCS Efficacy
The aim of this study is to compare analgesic efficacy of two non invasive techniques based on motor cortex stimulation in neuropathic pain patients.
- Trial name
- NI-MCS (NCT01800136)
- Testing
- Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Sleep Apnea Syndromes, Epilepsies, Partial
Study of the Efficacy of the Treatment of Sleep Apnea Syndrome by CPAP in Pharmacoresistant Epilepsy
Study of the Efficacy of the Treatment of Sleep Apnea Syndrome by CPAP in Pharmacoresistant Epilepsy. The primary goal is to evaluate the efficacity after 3 months of obstructive sleep apnea syndrome treatment by CPAP on the…
- Trial name
- SASER (NCT03200769)
- Testing
- CPAP active
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Lille
Transcranial Electric Stimulation, tDCS
Optimized and Personalized Trans-cranial Brain Stimulation in Partial Refractory Epilepsies
Epilepsy is one of the most common neurological diseases, affecting between 0.5% and 1% of the general population. Therefore, new diagnostic and treatment methods are having a big impact on society.
- Conditions
- Transcranial Electric Stimulation, tDCS, Epilepsy, Pharmacoresistant
- Trial name
- PerEpi2 (NCT06212609)
- Testing
- transcranial electrical stimulation therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Unverricht-Lundborg Disease
Intravenous Immunoglobulin for Unverricht-Lundborg Disease.
Single patient randomized double blind trial to assess whether intravenous immunoglobulin can improve the clinical outcome of a case suffering from Unverricht-Lundborg disease.
- Trial name
- NCT03351569
- Testing
- Intravenous immunoglobulin
- Volunteers
- 1 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Mantova
Neuropathic Pain
Cortical Plasticity After Motor Cortex Stimulation in Healthy Subject and Chronic Pain Patients
The primary aim of this study is to evaluate the induction of sensory-motor cortex plasticity after motor cortex stimulation in healthy subjects, using laser-evoked nociceptive cortical potentials, and in chronic neuropathic pain…
- Trial name
- NCT02849834
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Partial Epilepsy
Study Comparing Best Medical Practice With or Without VNS Therapy in Pharmacoresistant Partial Epilepsy Patients
This is a post-market medical device study. This study will compare best medical practice with or without adjunctive VNS Therapy in patients who are 16 years and older with pharmacoresistant partial epilepsy.
- Trial name
- NCT00522418
- Testing
- Vagal Nerve Simulation (VNS) Therapy, Best Medical Practive
- Where
- 48 sites in Belgium, Canada and 8 more
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Cyberonics, Inc.
Partial Epilepsy, Surgery
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy
The main objective of the study is twofold: 1. Assess the clinical efficacy of DBS on epilepsy according to their number and severity at 1 year follow up. 2.
- Trial name
- FRANCE (NCT02076698)
- Testing
- AN-DBS, Usual treatment
- Where
- 12 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Infantile Spasms
Acceptability Study of a New Paediatric Form of Vigabatrin in Infants and Children With Infantile Spasms or Pharmacoresistant Partial Epilepsy
The sponsor is developing a new paediatric formulation of vigabatrin to better adjust the dose to body weight and to limit waste of unused drug.
- Trial name
- SoluWest (NCT02220114)
- Testing
- Vigabatrin: Vigabatrin new ST formulation then Sabril®
- Where
- 12 sites in France
- Volunteers
- 38 people
- Sponsor
- Orphelia Pharma
Epilepsy
Efficacy of Modified Ketogenic Diet (Atkins) in Management of Epilepsy
The purpose of this study is to determine whether patients with uncontrolled epilepsy can follow a low carbohydrate diet long-term and if so, how will that diet affect their seizures
- Trial name
- NCT00188500
- Testing
- atkins diet, ability to follow low carbohydrate diet
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Focal Epilepsy
Cortical Excitability Assessment Using Paired Pulses
The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG).
- Trial name
- PP (NCT02245061)
- Testing
- paired pulses cortical electrical stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Pharmacoresistant Depression
Efficacy of Deep Transcranial Magnetic Stimulation (TMS) for Treatment-resistant Depression and Neuroanatomical Correlates: a Clinical Study Coupled With Positon Emission Tomography (PET)
Repetitive transcranial magnetic stimulation (TMS) is an emergent non-invasive treatment for treatment resistant depression (TRD).
- Trial name
- NCT02559466
- Testing
- Transcranial Magnetic Stimulation (TMS - ) - MagPro®, Positon Emission Tomography (PET) - Discovery 710®
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Epilepsy
The Modified Ketogenic Diet for the Treatment of Pharmacoresistant Epilepsy in Adults
The Modified Ketogenic Diet for the Treatment of Pharmacoresistant Epilepsy in Adults: an Observational Cohort Study
- Trial name
- NCT03425110
- Testing
- Modified Ketogenic Diet
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Birmingham and Solihull Mental Health NHS Foundation Trust