Clinical trials: Pharmakokinetic
Renal Failure
The Pharmacologic Profile of Sodium Thiosulfate in Renal Failure and Healthy Volunteers
The pharmacokinetics of sodium thiosulfate in humans with different degrees of renal failure and in healthy volunteers will be after two single shot applications.
- Trial name
- NCT01008631
- Testing
- Sodium thiosulfate
- Where
- Switzerland
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy
Bioequivalence Evaluation of Two Film-Coated Formulations of Valsartan 160 mg
This was a randomized, single-blind, two-period, two sequence cross-over study under fasting condition, with a one-week wash-out period, to compare the pharmacokinetic profiles and bioavailability of two formulations (the test…
- Trial name
- NCT02518451
- Testing
- Valsartan 160 mg film-coated caplets (test formulation), Valsartan 160 mg film-coated caplets (reference formulation)
- Where
- Indonesia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dexa Medica Group
Pain
Single Dose Pharmacokinetics of Egalet® Hydrocodone
The purpose of the study is to evaluate the pharmacokinetic profile of different Egalet® hydrocodone formulations and compare to a marketed hydrocodone drug.
- Trial name
- NCT00802087
- Testing
- hydrocodone, hydrocodone & acetaminophen combination
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Healthy Volunteers
Influence on Erythropoetin-level by Xenon
The purpose of this study is to analyze the effect of xenon-inhalation on erythropoetin-level in blood of healthy volunteers and to determine the efficient time of inhalation.
- Trial name
- XEPO (NCT02129400)
- Testing
- Xenon pro Anaesthesia 100 % (V/V), Aer medicinalis Linde 100%
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Orphan Cholestatic Liver Diseases, Primary Biliary Cirrhosis
A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384
The primary objectives of the study are to evaluate the safety, tolerability and pharmacokinetics of A4250 after single or multiple oral doses in healthy subjects.
- Conditions
- Orphan Cholestatic Liver Diseases, Primary Biliary Cirrhosis, Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome
- Trial name
- NCT02963077
- Testing
- A4250, CRC (A3384), Questran
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Albireo
Periodontitis
A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva
This exploratory study is the first study in a clinical program where the overall objective is to develop a novel pharmaceutical therapy comprising local administration of GM-CSF for the treatment of periodontitis.
- Trial name
- NCT00689143
- Testing
- sargramostim
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Innoventus Project AB
Healthy Volunteers
Bioavailability, Pharmacokinetics and Tissue Distribution of R-flurbiprofen Capsules in Healthy Subjects
For previous clinical trials, R-flurbiprofen has been prepared in tablet form. In this study R-flurbiprofen, will be available as gelatine capsules.
- Trial name
- NCT02206854
- Testing
- R-flurbiprofen
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gerd Geisslinger
Pharmakokinetic
A Drug-Drug Interaction Study to Study the Effect of AZD1981 on Warfarin
The primary purpose of this study is to determine whether the treatment with AZD1981 affect the exposure of Warfarin.
- Trial name
- NCT01199341
- Testing
- AZD1981, Warfarin
- Where
- Sweden
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pharmakokinetic, Open Label
A Phase 1, Open-Label, Parallel-Group, Single-Dose Study To Compare The Pharmakokinetics Of TNX-102 SL (Cyclobenzaprine Hydrochloride Sublingual Tablet) In Non-Elderly Versus Elderly Participants
TNX-102 SL has recently been approved by the United States (US) Food and Drug Administration (FDA) under the brand name TONMYA for the treatment of fibromyalgia.
- Conditions
- Pharmakokinetic, Open Label, Phase 1
- Trial name
- NCT07413367
- Testing
- TNX-102 SL Tablet
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tonix Pharmaceuticals, Inc.