Clinical trials: Pharyngeal Diseases
Nasopharyngeal Neoplasms
Gemcitabine and Oxaliplatin (GEMOX) in First Line Metastatic or Recurrent Nasopharyngeal Carcinoma
Primary objective: To evaluate the response rate of biweekly gemcitabine and oxaliplatin (the GEMOX regimen) in the first line treatment of metastatic or recurrent nasopharyngeal carcinoma.
- Trial name
- NCT00436800
- Testing
- Gemcitabine, Oxaliplatin
- Where
- Hong Kong
- Volunteers
- 41 people
- Sponsor
- Sanofi
Oropharyngeal Dysphagia
Investigation of a Free Water Protocol
Hypothesis: Use of a Free Water Protocol (FWP) will improve patient satisfaction scores (Dysphagia Handicap Index), will not increase the risk of aspiration pneumonia/pneumonitis, and will result in improved oral hygiene (as…
- Trial name
- NCT06309602
- Testing
- Free Water Protocol, Control / Standard Care
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Poudre Valley Health System
Nasopharyngeal Carcinoma
Phase Ⅲ Trial of Adjuvant Chemotherapy in Patients With N2-3 Nasopharyngeal Carcinoma
To see the effect if a combination of concurrent chemoradiotherapy followed by different adjuvant chemotherapy in treating patients with N2-3 nasopharyngeal carcinoma(NPC).
- Trial name
- NCT03321539
- Testing
- CCRT+GP, CCRT+PF
- Where
- 4 sites in China
- Volunteers
- 216 people
- Sponsor
- Sun Yat-sen University
Dysphagia, GERD
Does Use of Topical Lidocaine in EGD Reduce Amount of IV Midazolam and Fentanyl Required and Shorten Recovery Time
Patients will be randomized to a placebo or study group who will receive topical lidocaine prior to EGD. Amount of medication used, recovery time, patient/endoscopist satisfaction will then be assessed.
- Conditions
- Dysphagia, GERD, Abdominal Pain
- Trial name
- NCT02620501
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Brooke Army Medical Center
Nasopharyngeal Carcinoma
Neoadjuvant Therapy of GP Chemotherapy Combined With Tislelizumab in Locoregionally Advanced NPC
The purpose of this study is to explore the efficacy and safety of a combination of GP chemotherapy and tislelizumab in neoadjuvant therapy of locoregionally advanced nasopharyngeal carcinoma patients.
- Trial name
- NCT04833257
- Testing
- GP combine with Tislelizumab neoadjuvant therapy+CCRT
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Sun Yat-sen University
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Postoperative Complications
Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat
A prospective randomized double-blind study including patients ASA I-II, aged more than 18 years undergoing surgery under general anesthesia (GA) and endotracheal intubation.
- Trial name
- NCT04705948
- Testing
- Magnesium sulfate versus ketamine
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Tunis El Manar
Nasopharyngeal Carcinoma
Hypoxia Imaging -Guided Radiotherapy of Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) differs from other head and neck malignancies in terms of its epidemiology, pathology, and treatment outcome . It is endemic in China and is one of the major public health problems.
- Trial name
- NCT02089204
- Testing
- FMISO-PET/CT, FDG-PET/CT, contrast-enhanced CT
- Volunteers
- 300 people
- Sponsor
- Xuzhou Medical University
Streptococcus Group A
Mol Epi GrAS in Nicaragua
The purpose of this study is to determine the epidemiology of throat isolates of group A streptococci among 3-15 year-old children with pharyngitis (sore throat) living in Leon, Nicaragua.
- Trial name
- NCT00170521
- Where
- Nicaragua
- Volunteers
- 13,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dysphagia
Measuring Pharyngeal Muscle Improvements Following Behavioral Swallowing Exercises
The purpose of this study is to learn more about how exercise and protein supply affect swallow muscles. Twenty healthy older adults will be recruited from local community centers, physician offices, and retirement communities…
- Trial name
- NCT05080725
- Testing
- TelePEPP intervention
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Caregiver Burden, Alzheimer Disease
Reducing Burden in Care Partners of Community-Dwelling Persons With Dementia and Oropharyngeal Dysphagia
The goal of this clinical trial is to learn if a newly-created website tool, called WeCareToFeedDysphagia, helps to reduce feelings of burden in care partners of patients with Alzheimer's disease and related dementias (AD/ADRD)…
- Conditions
- Caregiver Burden, Alzheimer Disease, Dementia, Oropharyngeal Dysphagia
- Trial name
- NCT06557863
- Testing
- WeCareToFeedDysphagia web tool
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Tonsillitis
Airway Management in Children Undergoing Adenotonsillectomies
Secure airway management is the basis of all anesthesiological practice. Of particular importance is the securing of patients' airway passages when the surgical procedure itself poses a threat to a patient's airway, as is the…
- Trial name
- NCT00570414
- Testing
- Laryngeal mask airway, Endotracheal tube
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Sykehuset Telemark
Dysphagia
External Pharyngeal Exerciser and Dysphagia
The goal of this a clinical trial is to test the effect of a pharyngeal exerciser in rehabilitation of pharyngeal phase of swallowing in patients with dysphagia.
- Trial name
- NCT05708898
- Testing
- Pharyngeal exerciser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Dysphagia, Oropharyngeal
Oral Screens in Post Stroke Training
Stroke is a common disease in older people, and often leads to various degrees of disability. Dysphagia is one such consequence which is associated with aspiration pneumonia and malnutrition.
- Trial name
- NCT03167892
- Testing
- Oral screen
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Dysphagia, Laryngeal Edema
Corticosteroids for Post-Extubation Dysphagia
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal…
- Trial name
- COPED (NCT06670521)
- Testing
- Methylprednisolone, Normal Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Dysphagia, Heart Transplant Recipients
Respiratory Strength Training in Heart Transplant Recipients
This research study is investigating whether completing breathing exercises before surgery helps heart transplant patients recover after surgery.
- Trial name
- NCT06190171
- Testing
- Active respiratory muscle strength training
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Human Papilloma Virus, Cervical Cancer
M7824 in Subjects With HPV Associated Malignancies
Background: In the United States, each year there are more than 30,000 cases of human papillomavirus (HPV) associated cancers. Some of these cancers are often incurable and are not improved by standard therapies.
- Conditions
- Human Papilloma Virus, Cervical Cancer, Oropharyngeal Cancer, Anal Cancer
- Trial name
- NCT03427411
- Testing
- M7824
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Oropharynx Cancer
Adaptative Radiotherapy to Decrease Xerostomia in Oropharynx Carcinoma
The Phase III study will include 174 patients with locally advanced oropharynx carcinoma, receiving all arc-IMRT (Intensity-Modulated Radiation Therapy) (70 Gy) with concomitant systemic therapy.
- Trial name
- ARTIX (NCT01874587)
- Testing
- adaptative radiotherapy
- Where
- 11 sites in France
- Volunteers
- 132 people
- Sponsor
- Center Eugene Marquis
Head and Neck Cancer
Acute and Longlasting Side Effects Caused by Radiotherapy in the Head and Neck Area
The purpose of this clinical investigation is to evaluate acute and longlasting side effects in patients undergoing radiotherapy for cancer treatment in the head and neck area.
- Trial name
- NCT00995319
- Where
- Norway
- Volunteers
- 58 people
- Sponsor
- Norwegian University of Science and Technology
Deglutition Disorders, Stroke
Computerized Acoustic Swallowing Evaluation
It is the purpose of this study to determine if a commercially available electronic stethoscope synchronized with an smart phone or iPad application can be used as an accurate and objective screening tool for measuring dysphagia.
- Trial name
- CASE (NCT02925507)
- Testing
- Swallowing Screen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
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