Clinical trials: Phase 1
Rabies Human, Antibody
Prevention of Rabies With Four Doses of Rabies Vaccine
To evaluate the non inferiority of the immunogenicity of the test vaccine inoculated according to the four dose immunization program over the five dose immunization program and the batches consistency of immunogenicity according…
- Trial name
- NCT05545371
- Testing
- immunization procedures
- Where
- China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Changchun Zhuoyi Biological Co., Ltd
Pharmacokinetics of ASP015K, Bioavailability of ASP015K
A Single Oral Dose Study to Compare the Bioavailability Between Two Different Tablet Formulations and Assess if There is a Food Effect With the New Formulation
The purpose of this study is to determine the bioavailability and pharmacokinetics between two different formulations of ASP015K tablets and determine the food effect on the absorption of the new formulation.
- Conditions
- Pharmacokinetics of ASP015K, Bioavailability of ASP015K, Healthy Subjects
- Trial name
- NCT01484964
- Testing
- ASP015K
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Volunteers
Double-blind, Randomized, Placebo-controlled Study of the Safety, Tolerability and Pharmacokinetics of Ascending Doses of XC243 After Single and Multiple Oral Administration in Healthy Volunteers.
A double-blind, randomized, placebo-controlled, Phase I clinical study of the safety, tolerability and pharmacokinetics (PK) of ascending doses of XC243 after single and multiple oral administration in healthy volunteers.
- Trial name
- NCT05628116
- Testing
- XC243 50 mg single, XC243 100 mg single, XC243 200 mg single-dose food effect
- Where
- Russia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- PHARMENTERPRISES LLC
Healthy Volunteer
A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects
This study is a Phase 1, randomized, double-blind, placebo-controlled study of multiple doses of SAGE-718 using ketamine challenge to evaluate the electrophysiology, safety, tolerability, and pharmacokinetics in healthy subjects.
- Trial name
- NCT03844906
- Testing
- SAGE-718
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Healthy Volunteers
A Study to Assess Safety, Tolerability, PK and PD of AZD2373 in Healthy Male Participants of Sub-Saharan West African Ancestry
This is a Phase 1 study to assess the the safety, tolerability and pharmacokinetics (PK) of AZD2373, following subcutaneous (SC) administration of multiple ascending doses (MAD) of AZD2373 in healthy male participants of…
- Trial name
- NCT05351047
- Testing
- AZD2373 subcutaneous injection
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Study to Evaluate the Effects of Single and Multiple Doses of Hemay005 Tablets in Health Caucasian Adult Volunteers
The purpose of the study is to assess the safety and tolerability of single and multiple oral doses of Hemay005 tablets in healthy Caucasian adult volunteers.
- Trial name
- NCT05941247
- Testing
- Hemay005 60 mg
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ganzhou Hemay Pharmaceutical Co., Ltd
Influenza
Safety of Synbiotics as Adjuvant to Influenza Vaccine in Elderly
Probiotics are viable commensal microorganisms that promote the establishment of beneficial microflora. Animal and human studies demonstrate that probiotics can enhance body's immune response to stimuli.
- Trial name
- NCT01304771
- Testing
- Synbiotic AKSB
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COVID-19
SAD Study of APR002 Investigating the Safety/Tolerability, Pharmacokinetics/Pharmacodynamics in Healthy Subjects
This study will investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single ascending doses of APR002 in healthy subjects.
- Trial name
- NCT05268198
- Testing
- APR002
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Global Health Drug Discovery Institute
Hepatic Impairment (HI)
A Study to Evaluate EDG-7500 in Adults With Hepatic Impairment
The purpose of this Phase 1 study is to understand and compare the amount of EDG-7500 in the blood after a single dose in participants with different levels of liver function impairment versus participants with normal liver…
- Trial name
- NCT07324616
- Testing
- EDG-7500
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Edgewise Therapeutics, Inc.
Influenza
H5N1 Vaccine Intramuscular Versus Intradermal in Healthy Adults
The purpose of this research study is to compare how the body reacts to different strengths of an H5N1 flu vaccine when given by different routes of injection (injection into the skin or into the muscle).
- Trial name
- NCT00310206
- Testing
- Inactivated Influenza A Vaccine A/H5N1
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes
The Metabolite Identification and Material Balance Study of SP2086
The purpose of the study is to investigate the Metabolite identification and material balance of SP2086 in healthy adult volunteers.
- Trial name
- NCT02815748
- Testing
- SP2086
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy
Phase I Single and Multiple Escalating Dose Study of RGN1016 in Healthy Male Subjects
This is a double-blind, randomized, placebo-controlled, dose-escalating, single dose and multiple dose study.
- Trial name
- NCT02820155
- Testing
- RGN1016
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy
A Food Effect Study of CT-L01 After Oral Administration in Healthy Volunteers
This is a phase 1, randomized, open-label, single-dose, crossover, single-center study to evaluate food effect on the pharmacokinetics and safety of CT-L01 after oral administration in healthy volunteers.
- Trial name
- NCT05364164
- Testing
- CT-L01 12.5/1,000 mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Celltrion
Healthy Volunteer
A Phase 1 SAD/MAD Study of RLS-0071 in Healthy Volunteers in Support of a COVID-19 Development Program
This is a Phase 1, single-center, randomized, double-blind, placebo-controlled, adaptive-design study to assess the safety, tolerability, PK, and PD of single- and multiple-ascending doses of RLS-0071 in healthy adult subjects.
- Trial name
- NCT05298787
- Testing
- RLS-0071
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- ReAlta Life Sciences, Inc.
EC905, Pharmacokinetics
A Study to Compare the Amount of Drug in the Blood After a Single Tablet EC905 Containing Solifenacin and Tamsulosin is Taken by Healthy Males Compared to Separate Tablets of Solifenacin and Tamsulosin
A study to assess the amount of drug in the blood of young to middle aged, healthy, male subjects after they received the final formulation of EC905 compared to solifenacin (Vesicare®) and tamsulosin OCAS (Omnic OCAS®).
- Conditions
- EC905, Pharmacokinetics, Healthy Subjects
- Trial name
- NCT01953887
- Testing
- EC905, solifenacin, tamsulosin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Pertussis, Whooping Cough
Study of BPZE1 Intranasal Pertussis Vaccine (Administered Via VaxINator(TM)), Prime + Boost, in Healthy Adults
This study evaluates the safety and immunogenicity of the BPZE1 live attenuated pertussis vaccine, intended to prevent nasopharyngeal colonization and pertussis disease, and compares a single (prime) BPZE1 dose or BPZE1 2-dose…
- Trial name
- NCT03942406
- Testing
- BPZE1 pertussis vaccine and VaxINator(TM) Atomization Device
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ILiAD Biotechnologies
Liver Cancer, Hepatocellular Carcinoma
Application of mRNA Immunotherapy Technology in Hepatitis B Virus-related Refractory Hepatocellular Carcinoma
The purpose of this study is to evaluate the efficacy and safety of mRNA vaccine for HBV-positive Advanced Hepatocellular Carcinoma.
- Trial name
- NCT05738447
- Testing
- HBV mRNA vaccine
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Healthy Volunteers
Single/ Multiple-Dose Study of E6007 in Healthy Japanese Male Subjects
This is a single-center, placebo-controlled, randomized, ascending dose, double-blind study. This study will be evaluating ascending doses of 50, 100, 200, and 400 mg of E6007. This study consists of 5 steps, 1 to 5.
- Trial name
- NCT02268838
- Testing
- E6007
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eisai Co., Ltd.
Phase 1
The Safety, Tolerability, Pharmacokinetics and Food Effects of SHEN211 Tablet in Healthy Subjects
This is a study to evaluate the safety, tolerability, pharmacokinetics, and food effects of SHEN211 tablet in healthy subjects after fasting single or multiple oral administration
- Trial name
- NCT06214858
- Testing
- SHEN211 tablets
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- JKT Biopharma Co., Ltd.
Healthy Volunteers
Phase 1 Safety and PK Study of OLT1177 Capsules
This study is a randomized, placebo-controlled, sequential ascending-dose study of healthy volunteers after administration of single or multiple dose(s) of investigational drug (OLT1177 Caps or Placebo Caps).
- Trial name
- NCT02134964
- Testing
- OLT1177 Capsules
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Olatec Therapeutics, Inc.
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