Clinical trials: Phase 2
Menstrual Cycle Phase
Menstrual Cycle and Exercise-induced Muscle Damage
The aim of the study is to investigate the effect of the different menstrual cycle phases on the recovery from exercise-induced muscle injury in eumenorrheic women.
- Trial name
- MC-EIMD (NCT07322874)
- Testing
- Exercise during follicular phase, Exercise during luteal phase
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chariklia K. Deli
American Society of Anesthesiologists (ASA) I-II Risk Groups, the Follicular (Days 1-12 From Last Menstruation) or Luteal (Days 20-24) Phase of the Menstrual Cycle
Menstrual Cycle Phase and Virtual Reality on Preoperative Anxiety
This study aims to examine the effects of menstrual cycle phase and a virtual reality (VR) intervention on preoperative anxiety in female patients scheduled for septorhinoplasty surgery.
- Conditions
- American Society of Anesthesiologists (ASA) I-II Risk Groups, the Follicular (Days 1-12 From Last Menstruation) or Luteal (Days 20-24) Phase of the Menstrual Cycle, Aged 18-55
- Trial name
- NCT07337941
- Testing
- 15-minute video providing a visual and auditory experience (Training Video), State-Trait Anxiety Inventory (STAI I-II), The decision for a 15-minute preoperative observation without visual and auditory experience depends on the phase of the menstrual cycle and group assignment.
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Early-phase Safety and PK Study of a Vaginal Gel
FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL
The goal of this clinical trial is to assess the safety and pharmacokinetics of YASO GEL in healthy adult participants. This is a first-in-human study designed to understand how the gel is absorbed and distributed in plasma and…
- Trial name
- PPCM-01 (NCT07281404)
- Testing
- YASO GEL
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yaso Therapeutics Corporation
Cesarean Delivery, Cervical Ripening
Latent Phase Membrane Stripping for Caesarean Section Reduction
In the Hospital Escuela, the availability of beds and criteria for admission to the intensive care unit ICU are not the same, the use of this marker is questionable, as it is affected by the level of complexity of care provided…
- Conditions
- Cesarean Delivery, Cervical Ripening, Latent Phase Labour
- Trial name
- DEMEM (NCT06809985)
- Testing
- Hamilton maneuver
- Where
- Honduras
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
Functional Dyspepsia, BIA
Bio-electrical Impedance Analysis in Patients With Functional Dyspepsia
The primary objective of this study is to compare the BIA parameters, including Phase Angle, Fat Free Mass and Fat Mass, between women with functional dyspepsia and healthy women.
- Conditions
- Functional Dyspepsia, BIA, Fat Free Mass, Fat Mass
- Trial name
- NCT07196735
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Pregnancy, No Pregnancy Complications
Effect of Maryam Plant and Surah on Birth Pain, Anxiety and Satisfaction
This randomized controlled trial was conducted to determine the effects of spiritual support provided by Virgin Mary's hand plant and Surah Maryam on labor anxiety, labor pain, and satisfaction.
- Conditions
- Pregnancy, No Pregnancy Complications, Cervical Dilatation of 4-6 cm (Early Active Phase), Muslim
- Trial name
- NCT07175337
- Testing
- Surah Maryam group, Virgin Mary's Hand Plant Group
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Delayed Sleep Phase
Delayed Sleep Timing in Teens Study
This study will (1) comprehensively characterize the substance use disorder (SUD) risk profile associated with adolescent Delayed Sleep Phase (DSP), and (2) probe whether SUD risk is diminished by altering sleep/circadian timing.
- Trial name
- NCT03806296
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep scheduling
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm
Biomarkers for Circadian Timing in Healthy Adults
Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.
- Conditions
- Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT03956745
- Testing
- sleep-wake timing, constant routine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder
Breath Biomarkers for Sleep Loss and Circadian Timing
Insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency.
- Conditions
- Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic
- Trial name
- NCT03980340
- Testing
- Short Nap Intervention, No Nap Intervention
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pregnancy, Latent Phase
Hydrotherapy in Labor: Outcomes for Pain, Birth, and Breastfeeding
Warm showers are increasingly gaining attention for their positive impact on labor, yet studies on this topic in Turkey remain limited.
- Trial name
- HYDROTHERAPY (NCT07031635)
- Testing
- Hydrotherapy (Warm Shower)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Selcuk University
This is a Phase I Study Conducted in Healthy Volunteers
AVT03 With Xgeva in Healthy Male Subjects
This study has been designed as a randomized, double-blind, parallel-group study and in healthy adult male subjects of age 28 years to 55 years old.
- Trial name
- NCT05876949
- Testing
- AVT03, Denosumab
- Where
- 3 sites in Poland, South Africa and 1 more
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Alvotech Swiss AG
Accelerated/Blast-phase Myeloproliferative Neoplasm, Chronic-phase Myelofibrosis
Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation
The presence of IDH mutation is associated with worse survival in patients with myelofibrosis. Moreover IDH mutations are among the most frequently encountered events in MPNs that have progressed to acute myeloid leukemia.
- Conditions
- Accelerated/Blast-phase Myeloproliferative Neoplasm, Chronic-phase Myelofibrosis, IDH2 Mutation
- Trial name
- NCT04281498
- Testing
- Ruxolitinib, Enasidenib
- Where
- 11 sites in United States, Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- John Mascarenhas
Menstrual Cycle Phase, Muscle Protein Synthesis
The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis
The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been…
- Trial name
- NCT06268678
- Testing
- Phase of the menstrual cycle
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy Adults (Full Study and Extension Phase), Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
The MedSeq™ Project seeks to explore the impact of incorporating information from a patient's whole genome sequence into the practice of clinical medicine.
- Trial name
- NCT01736566
- Testing
- Family History + Whole Genome Sequencing, Family History Only
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dysphagia After Stroke, Cortical Swallowing Network
To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling
Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity.
- Conditions
- Dysphagia After Stroke, Cortical Swallowing Network, Functional Magnetic Resonance Imaging, Oral Phase
- Trial name
- NCT06564688
- Testing
- Swallowing function test
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fujian University of Traditional Chinese Medicine
Baseline/Control Phase, Intervention Phase
City For All Ages: Elderly-friendly City Services for Active and Healthy Ageing
Many city-dwelling elderly people can be greatly affected after a minor change in their living or health conditions. Mild Cognitive Impairment (MCI), early dementia and frailty are among the most common risks with deep…
- Trial name
- NCT06486935
- Testing
- IoT sensors, Traditional/Manual elderly monitoring
- Where
- 2 sites in France, Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Double Vaccinated for COVID-19 (For Phase 1 of the Study), Acute Respiratory Syndrome Coronavirus 2 (For Phase 2 Exploratory Group)
Clinical Trial to Study the COVAC-2 Booster Dose (for COVID-19) in Generally Healthy Adults.
VIDO has developed a vaccine called COVAC-2. The COVAC-2 study vaccine contains a portion of the SARS-CoV-2 spike protein, called S1.
- Trial name
- NCT05226702
- Testing
- COVAC-2
- Where
- 3 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Assessing Interest in a Platform for Early Phase Clinical Trial Recruitment
Assessing Interest in Web/App Platforms for Early Phase Clinical Trial Recruitment
Study objective: To assess whether the different stakeholders (volunteers, patients, doctors and industry) involved in early phase trials would be interested in using a platform to facilitate recruitment and engagement in this…
- Trial name
- NCT06302647
- Testing
- Questionnaires
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Phase 1
A Study to Examine the Effect of Tesofensine and Metoprolol on the 24-hour Mean Heart Rate
A Phase 1 Study to Examine Pharmacodynamic Interaction Between Tesofensine and Metoprolol on 24-hours Mean Heart Rate
- Trial name
- NCT03488719
- Testing
- Metoprolol Succinate 25 MG, Metoprolol Succinate 50 MG, Metoprolol Succinate 100 MG
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Saniona
Phase 1
The Safety, Tolerability, Pharmacokinetics and Food Effects of SHEN211 Tablet in Healthy Subjects
This is a study to evaluate the safety, tolerability, pharmacokinetics, and food effects of SHEN211 tablet in healthy subjects after fasting single or multiple oral administration
- Trial name
- NCT06214858
- Testing
- SHEN211 tablets
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- JKT Biopharma Co., Ltd.