Clinical trials: Phase III
Staphylococcal Infections
Evaluation of Consistency of StaphVAX Manufacturing Lots
This study answers a U.S. Food and Drug Administration requirement for evaluation in people of the consistency of manufacturing of a vaccine. Subjects are randomized to one of three lots of vaccine.
- Trial name
- NCT00211991
- Testing
- S. aureus Type 5 & 8 Capsular Polysaccharide Conjugate
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Nabi Biopharmaceuticals
Meningitis, Meningococcal
A Phase III Clinical Trial of the Group A and C Meningococcal Polysaccharide Vaccine
This study is a randomized, double-blinded, and controlled phase III clinical trial of the Group A and C meningococcal polysaccharide vaccine to evaluate the safety and immunogenicity of the vaccine in healthy infants aged 2-6…
- Trial name
- NCT04689191
- Testing
- Experimental Group A and C meningococcal polysaccharide vaccine, Control Group A and C meningococcal polysaccharide vaccine
- Where
- China
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Influenza
A Phase III, Open-Label, Single-Dose Study to Evaluate the Safety and Immunogenicity of Fluviral® Vaccine
Vaccination is currently the most effective means of controlling influenza and preventing its complications and mortality in persons at risk.
- Trial name
- NCT00505453
- Testing
- Fluviral®
- Where
- 2 sites in Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza, Seasonal Influenza
Yearly Strain Variation Study, 2010/2011
The purpose of the study is to verify the immunogenicity and tolerance of a trivalent seasonal influenza vaccine with strain composition according to WHO/EU recommendation for the 2010/2011 season for yearly licensing application.
- Trial name
- NCT01157702
- Testing
- Inactivated influenza vaccine (split virus, Vero cell-derived)
- Where
- Austria
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
HIV-1 Infection
DOR/ISL in HIV-1 Antiretroviral Treatment-naïve Participants (MK-8591A-053)
This is a randomized, active-controlled, double-blind clinical study designed to evaluate the antiretroviral activity, safety, and tolerability of doravirine/islatravir (DOR/ISL [MK-8591A]) in treatment-naïve participants with…
- Trial name
- NCT05705349
- Testing
- DOR/ISL, BIC/FTC/TAF
- Where
- 131 sites in United States, Argentina and 19 more
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Malaria, Malaria,Falciparum
Attractive Targeted Sugar Bait Phase III Trial in Zambia
The trial will evaluate the efficacy of ATSB deployment plus universal coverage of a WHO core vector control (VC) interventions over two transmission seasons on a minimum 30% reduction in cohort clinical disease incidence…
- Conditions
- Malaria, Malaria,Falciparum, Vector-Borne Transmission of Infection
- Trial name
- NCT04800055
- Testing
- Attractive Targeted Sugar Bait
- Where
- Zambia
- Volunteers
- 3,480 people, healthy volunteers welcome
- Sponsor
- PATH
Microscopic or Gross Hematuria
Hematuria Evaluation Trial for Subjects With Microscopic or Gross Hematuria to Determine the Absence or Presence of Bladder Cancer
The purpose of the study is to evaluate subjects with gross or microscopic hematuria undergoing scheduled cystoscopy to determine the absence or presence of bladder cancer.
- Trial name
- NCT00975455
- Where
- 13 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Predictive Biosciences
Smoking Cessation
Smoking Cessation Programme in Workplaces in Hong Kong (Phase III)
Smoking causes cardiovascular and respiratory diseases, cancers and diabetes, and it has been a leading risk factor for death globally.
- Trial name
- NCT03142555
- Testing
- Health talk plus intensive social media intervention, Health talk plus less intensive social media intervention
- Where
- Hong Kong
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pneumococcal Vaccines
13vPnC Multidose Vial Safety, Tolerability and Immunogenicity Study in Healthy Infants.
This study will compare the immune responses of the infants who have been given 13vPnC in the mutidose vial formulation to the immune reponses of the infants who have been given 13vPnC in the single-dose syringe formulation.
- Trial name
- NCT01964716
- Testing
- 13-valent pneumococcal conjugate vaccine
- Where
- 2 sites in The Gambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Pfizer
Prevention, Family Function
Familias Unidas: Preventing Substance Abuse in Hispanic Youth
The focus of this study will be to test the Familias Unidas Intervention program among Hispanic 8th graders in the Miami-Dade County Public School System.
- Conditions
- Prevention, Family Function, Substance Use, Sexual Behavior
- Trial name
- NCT01038206
- Testing
- Familias Unidas
- Where
- United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Miami
COVID-19, SARS-COV-2 Infection
A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That Are Considered at Higher Risk of Severe COVID-19
The purpose of this study is to learn about the safety, tolerability, and immunogenicity of an updated vaccine against COVID-19, called BNT162b2 (2025/2026 formulation).
- Trial name
- NCT07222384
- Testing
- BNT162b2 (2025/2026 formulation)
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Allergic Rhinitis
Non-inferiority, Open-label, Multicenter and Randomized Clinical Trial About the Treatment of Mild to Moderate Persistent Allergic Rhinitis
To assess the efficacy of the study product Noex in the treatment of allergic rhinitis by means of the Nasal Index Score (NIS) after 4 weeks of treatment with the drug.
- Trial name
- NOEX (NCT01022047)
- Testing
- Noex, Budecort Aqua
- Where
- Brazil
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Infection, Human Immunodeficiency Virus
Relative Bioavailability Study of Phase III Tablet Formulation of Cabotegravir
This study is a single-center, randomized, open-label, two cohorts, 3-way cross-over design in 36 subjects to assess the oral bioavailability of four new cabotegravir (CAB) sodium salt tablet formulations relative to the current…
- Trial name
- NCT02345707
- Testing
- Cabotegravir 30 mg current formulation, Cabotegravir 30 mg micronized new formulation 500 M, Cabotegravir 30 mg unmicronized new formulation 500 U
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Dengue
Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Administered With a Yellow Fever Vaccine in Adults
The main purpose of this study is to assess the immunogenicity and safety of the concomitant and sequential administration of yellow fever (YF) vaccine and tetravalent dengue vaccine (TDV) in healthy participants aged 18 to 60…
- Trial name
- NCT03342898
- Testing
- YF-17D, TDV
- Where
- 11 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Takeda
Intermittent Preventive Treatment In Pregnancy (IPTp)
Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa
The primary objective is to establish superiority of AZCQ over SP in protective efficacy for IPTp as measured by the proportion of subjects with sub-optimal pregnancy outcome.
- Trial name
- NCT01103063
- Testing
- Azithromycin plus chloroquine, sulfadoxine-pyrimethamine
- Where
- 9 sites in Benin, Kenya and 3 more
- Volunteers
- 2,891 people, healthy volunteers welcome
- Sponsor
- Pfizer
COVID-19
A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa
This is a multi-centre, double-blind, phase 3 study to observe the effectiveness, safety, and tolerability of molnupiravir 800 mg administered 12-hourly for five days in adult patients with mild COVID-19 at the time of enrolment…
- Trial name
- CoTeT (NCT05459532)
- Testing
- Molnupiravir 200 mg
- Where
- 4 sites in South Africa
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
COVID-19
Phase 3 Lot Consistency Study of Trivalent Hemagglutinin Nanoparticle Influenza Vaccine
Phase 3 Study Comparing Safety and Immune Response of Three Batches of Novavax Flu Vaccine in older adult participants
- Trial name
- NCT06485752
- Testing
- tNIV 1 and Matrix-M Adjuvant
- Volunteers
- healthy volunteers welcome
- Sponsor
- Novavax
Postoperative Nausea and Vomiting
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
The goal of this Interventional study is to evaluate the efficacy and safety of Aprepitant Injection(QLG2174) for preventing PONV in Chinese patients.
- Trial name
- NCT06932107
- Testing
- Aprepitant Injection
- Where
- China
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Breast Neoplasm Female, Symptom Cluster
Somatic Acupressure for Symptom Cluster Management in Breast Cancer Survivors
This study is designed following the updated Medical Research Council (MRC) Framework for Developing and Evaluating Complex Interventions.
- Trial name
- NCT06412107
- Testing
- True acupressure, Usual care
- Where
- 2 sites in China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Charles Darwin University
Gingivitis
A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
The purpose of this study is to evaluate and compare the gingival health of a test dentifrice (0.454% weight by weight [w/w] stannous fluoride) to a negative control dentifrice by comparing modified gingival index, bleeding index…
- Trial name
- NCT04123665
- Testing
- Stannous fluoride, Sodium monofluorophosphate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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