Clinical trials: Phenylephrine
Healthy, Drug Abuse
Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users
The purpose of this study is to assess the abuse potential of single doses of pitolisant relative to phentermine HCl and placebo, when administered to healthy, non-dependent, recreational stimulant users.
- Trial name
- NCT03152123
- Testing
- Pitolisant, Phentermine
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bioprojet
Alzheimer's Disease
AZD3293 Thorough QT Study in Healthy Male Volunteers
A thorough QT study of AZD3293
- Trial name
- AZD3293TQT (NCT02040987)
- Testing
- AZD3293, Moxifloxacin
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects
This study will evaluate pharmacokinetics (PK) of four different formulations with different release profiles of AZD9977 (PART A) in the fasted state, and one of the formulation will be selected for further development (Part B).
- Trial name
- NCT03450759
- Testing
- AZD9977 Oral suspension (reference), AZD9977 capsule, AZD9977 ER capsule (fastvrate)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypotension, Fluid Therapy
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
A prospective, double-blinded study. The present study consisted in applying Stroke volume variation fluid guided therapy to old patients (65 years old) undergoing radical resection of colon surgery.
- Trial name
- NCT03215797
- Testing
- phenylephrine, Norepinephrine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Healthy
T/QT Study to Investigate the Effect of Relacorilant on Cardiac Repolarization in Healthy Volunteers
This dedicated T/QT study will investigate the effect of relacorilant on cardiac repolarization in healthy participants.
- Trial name
- NCT04795479
- Testing
- Relacorilant, Moxifloxacin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Dermatitis, Atopic
A Pharmacokinetic Study to Evaluate BBI-5000 Capsules and Food Effect in Healthy Adult Subjects
To assess the pharmacokinetics of 3 doses and the food effect of a single high dose of BBI-5000 capsules in healthy adult subjects.
- Trial name
- NCT02590289
- Testing
- BBI-5000
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fresh Tracks Therapeutics, Inc.
Anesthetic Complication Spinal
Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
Rapid administration of crystalloid immediately after induction of spinal anesthesia (coload) to be more effective in terms of managing hypotension as compared to administering crystalloid before spinal anesthesia (preload).
- Trial name
- NCT01378325
- Testing
- Phenylephrine, saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Healthy
A Pharmacokinetic Study of Three Different Particle Sizes of PH-797804
The purpose of this study is to investigate the effects of varying particle size on the pharmacokinetics of PH-797804
- Trial name
- NCT01924650
- Testing
- PH-797804
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Pulmonary Disease, Chronic Obstructive
An Investigation of the Pharmacokinetics of GSK961081 and Fluticasone Propionate in Healthy Volunteers
In the current study GSK961081 and fluticasone propionate will be administered in a blended formulation from a single device and compared with GSK961081 and fluticasone propionate administered alone and concurrently.
- Trial name
- NCT01449799
- Testing
- GSK961081 800 microgram dose, Fluticasone Propionate 500 microgram dose, GSK961081 800 microgram and Fluticasone Propionate 500 microgram separately
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Systemic Exposure, Systemic Pharmacodynamics and Safety and Tolerability of FluticasoneFuroate, Umeclidinium and Vilanterol in Healthy Subjects
This is a double-blind, single dose (four inhalations), four-way cross over study in healthy subjects that will assess the systemic pharmacokinetics (PK) and systemic pharmacodynamics (PD) of Fluticasone Furoate, (FF)…
- Trial name
- NCT01691547
- Testing
- UMEC /VI, UMEC, VI
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants
The purpose of this study is to assess potential effects of enpatoran on cardiac repolarization (i.e. prolongation of QT interval).
- Trial name
- NCT06589726
- Testing
- Moxifloxacin, Enpatoran low dose, Enpatoran high dose
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Healthy Participants
A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult Participants
The purpose of this study is to assess the effects of loperamide on QT/ QT interval corrected for heart rate (QTc) intervals and electrocardiogram (ECG) morphology at therapeutic and supratherapeutic exposures in healthy…
- Trial name
- NCT04225078
- Testing
- Loperamide, Moxifloxacin
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Mydriasis, Dilation
Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects
The objectives of this study are: To evaluate the safety of Nyxol in pediatric subjects To evaluate the efficacy of Nyxol to expedite the reversal of pharmacologically induced mydriasis in pediatric subjects The Sponsor intends…
- Trial name
- MIRA-4 (NCT05223478)
- Testing
- Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Hypotension
Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IV
The primary objective of this study is to evaluate the dose effect of Phenylephrine Hydrochloride Injection on the treatment of clinically relevant decreased blood pressure in the pediatric population, ≥12 to 16 year old patients…
- Trial name
- NCT02323399
- Testing
- Phenylephrine
- Where
- 10 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West-Ward Pharmaceutical
Healthy
Comparative Bioavailability Study of Two Prototypes of Trazodone Controlled-release Products and Two Marketed Reference Products in Healthy Volunteers
The objectives of this study were: to compare the pharmacokinetic profiles of two prototype controlled-release (CR) trazodone hydrochloride (HCl) 300 mg tablets versus two reference products: Trittico® AC (2 x 150 mg CR tablets)…
- Trial name
- NCT01121913
- Testing
- Trazodone HCl
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Labopharm Inc.
Blood Pressure, Human Experimentation
Safety Study Comparing Phenylephrine HCL Extended Release Tablets 30 mg and Placebo (Study CL2007-07)(P07529)(COMPLETED)
Randomized, placebo-controlled double-blind, crossover design study; 116 subjects randomized on Day 1 to obtain 98 completed subjects.
- Trial name
- NCT00874120
- Testing
- Phenylephrine Hydrochloride (HCl) Extended-Release tablets 30 mg
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Bayer
Assess Pharmacokinetics of Ketorolac Tromethamine Intranasal and Assess Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
Study to Assess the PK of Ketorolac Tromethamine Intranasal and to Assess the Effects of a Oxymetazoline Hydrochloride on the PK of Ketorolac Tromethamine
This was an open label, two way crossover study in healthy male subjects. Two treatments were administered to each subject, one treatment per study period, in a randomized manner.
- Trial name
- NCT01363089
- Testing
- Ketorolac tromethamine, Oxymetazoline hydrochloride
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Egalet Ltd
Mydriasis
Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation
This study evaluated pupil dilation after administration of fixed combination tropicamide-phenylephrine (TR/PE) vs. phenylephrine (PE) alone and tropicamide (TR) alone. Participants attended 3 visits.
- Trial name
- MIST-1 (NCT03751631)
- Testing
- Tropicamide 1%-Phenylephrine 2.5% ophthalmic solution (TR/PE), Tropicamide 1% ophthalmic solution (TR), Phenylephrine 2.5% ophthalmic solution (PE)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Drug Overdose
Bioavailability of Nasal Naloxone and Injected Naloxone Compared
Opioid overdoses have in the last decade counted for about 230 untimely deaths annually in Norway. The government is currently implementing a strategy for combating this epidemic.
- Trial name
- OPI-15-002 (NCT02598856)
- Testing
- Intranasal (IN) naloxone 1x, Intranasal (IN) naloxone 2, Intravenous (IV) naloxone
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Food-drug Interaction
Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects.
to evaluate the comparative bioavailability of valproate from Orfiril long 500 mg prolonged release minitablets and Ergenyl chrono 500 mg prolonged-release tablets in healthy, male volunteers under fasting and fed conditions.
- Trial name
- NCT06211283
- Testing
- Sodium valproate
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Desitin Arzneimittel GmbH