Clinical trials: Photoaging
Photoaging, Hyperpigmentation
Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging
Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles.
- Conditions
- Photoaging, Hyperpigmentation, Rhytides
- Trial name
- NCT04586816
- Testing
- 1% red maple leaf extract in cream base, 5% red maple leaf extract, vehicle
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Skin Aging
Effect of Oligopin® on Skin Ageing
Extrinsic or exogenous ageing is caused by repetitive exposure of the skin to harmful agents, while primary cause the exposure to ultraviolet (UV) radiation, known as photoageing, including solar effect.
- Trial name
- OLIGOSKIN (NCT04141059)
- Testing
- Oligopin
- Where
- Spain
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Skin Health
To Determine the Activity and Mechanisms of Cranberries to Attenuate Skin Photoaging and Improve Skin Health in Women
Previous studies have shown that cranberry phytochemicals scavenge reactive carbonyls. Cranberry polyphenols have been reported to attenuate collagen degradation and inhibit oxidative stress in human cells.
- Trial name
- NCT04183920
- Testing
- Cranberry juice
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Photoaging, Lentigo
TCA 15% Chemical Peel for Improvement in Hand Lentigines
This study will evaluate the efficacy of the a 15% trichloroacetic acid + 3% glycolic acid peel combination for treatment of lentigines on the hands. This peel combination is sold over the counter.
- Trial name
- NCT05471947
- Testing
- 15% Trichloroacetic acid + 3% glycolic acid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Main Line Center for Laser Surgery
Photoaging
RFMN in Combination With 1927 nm Thulium Laser for Treating Photoaged Skin
The appearance of the aging skin is influenced by different factors including by the reduced elasticity and increased laxity of the skin, the decreasing volume as well as pigmentation disorders and dilated vascular markings.
- Trial name
- NCT06029725
- Testing
- radiofrequency microneedling combined with 1927 nm thulium laser, radiofrequency microneedling monotherapy
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Skin Photoaging, Inflammation and Skin Pathogenic Bacteria
The Effect of Pomegranate on Aging and Inflammation of the Skin
The purpose of this study is to determine the efficacy of pomegranate extract and pomegranate juice on skin inflammation and aging.
- Trial name
- PomSkin (NCT02258776)
- Testing
- Pomegranate Extract, Pomegranate Juice
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Photoaging
Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women
Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins.
- Trial name
- NCT04869852
- Testing
- Food
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Face Skin Photoaging
Face Photoaging: Efficacy and Tolerance Evaluation of an Intradermal Injective Treatment
Efficacy and tolerance evaluation of an intradermal injective treatment
- Trial name
- NCT03274232
- Testing
- SUNEKOS ® 200
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Face Photoaging
Aesthetic Performance of an Intradermal Injection Treatment for Face Photoaging: Interstitial or Cushion Technique in Comparison to Bolus Technique at Five Points (Half - Face Method Within Subjects)
Aesthetic performance of "SUNEKOS® 200" injectable treatment on main sign of face skin aging in normotypic or overweight subjects with rounded, oval or squared face and in thin subjects with oval or triangular face and "sagging"…
- Trial name
- NCT03425955
- Testing
- SUNEKOS ® 200, "SUNEKOS® 1200" and "SUNEKOS® 200"
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Collagen Degeneration, Wrinkle
The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal…
- Conditions
- Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
- Trial name
- NCT06571721
- Testing
- Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Photoaging
The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging
Our study involves the evaluation of a high potency peel in its efficacy for skin rejuvenation in the treatment of photoaging. This chemical peel regime is a high potency peel 70% glycolic acid combined with vitamin C that is…
- Trial name
- NCT02126644
- Testing
- 70% glycolic acid
- Where
- Singapore
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Skin Aging, Photoaging
Effects of Stabilized Retinaldehyde on Aging Skin: A Split-Face Study
The goal of this clinical trial is to learn if retinaldehyde cream improves the appearance of aging skin in women aged 30 to 60 years.
- Trial name
- NCT07510165
- Testing
- Stabilized retinaldehyde 0.1%, Stabilized retinaldehyde 0.05%
- Where
- Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Sun Damaged Skin
Efficacy Evaluation of Products Against Long Wavelength Ultraviolet A1 and Visible Light Induced Biological Effects
The purpose of this study is to evaluate the efficacy of topical products in providing protection against the visible light and ultraviolet A1 (UVA1) part of sunlight.
- Trial name
- NCT04181476
- Testing
- Sunscreening Agents
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Fine Lines, Wrinkles
A Clinical Study to Evaluate Efficacy and Safety of a Cosmetic Product in the Treatment of Facial Lines
This randomized, double-blind, placebo-controlled clinical trial was conducted to assess the efficacy and safety of an anti-aging serum to improve the appearance of expression lines as well as overall skin health of aging skin…
- Conditions
- Fine Lines, Wrinkles, Photoaging
- Trial name
- NCT04545970
- Testing
- Facial cleanser, Facial moisturizer, Sunscreen
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Chronological Aging of Skin, Photoaging of Skin
Autologous Platelet-Rich Plasma Cream for Photoaging and Chronological Skin Aging
Human skin undergoes some morphological changes with the effects of chronological aging and photoaging, these are especially remarkable in the facial skin.
- Trial name
- NCT02303496
- Testing
- Platelet Rich Plasma Cream
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Wrinkle, Photoaging
An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream
This single-center clinical trial is being conducted to assess the efficacy and tolerability of an anti-aging eye cream and face moisturizer when used over the course of 12 weeks twice-daily by women, 35-65 years, with mild to…
- Conditions
- Wrinkle, Photoaging, Fine Lines
- Trial name
- NCT04911374
- Testing
- Gentle Cleansing Lotion, Revision Skincare, Aveeno Face Milk SPF 40+
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Skin Diseases, Photoaging
Driving Time and Facial Skin Hydration Asymmetry in Florida Drivers
his observational study examines whether time spent driving is associated with differences in skin hydration between the left and right cheeks in female drivers residing in Florida.
- Conditions
- Skin Diseases, Photoaging, Skin Hydration
- Trial name
- DCHA-FL-25-65 (NCT07764809)
- Testing
- BT-Analyze bioimpedance skin hydration measurement
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IAS Skin Care
Photoaging
The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged Skin
This study is a double-blind randomized vehicle-controlled study assessing how Zinc Di-(dibutyryl lisinate) (Z-DBL) influences skin biophysical measures such as skin hydration, transepidermal water loss, and elasticity, as well…
- Trial name
- NCT06096649
- Testing
- Topical Vehicle + Zinc Di-(dibutyryl lisinate), Topical Vehicle
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Skin Manifestations, Wrinkle
A 56-day Clinical Study on Facial Skin Rejuvenation
This clinical trial aims to learn about the efficacy of MLYAAT-1002® (a proprietary anti-aging complex, MLYAAT is short for "multi-layer anti-ageing technology" ) in female subjects who have newly received the rejuvenation…
- Conditions
- Skin Manifestations, Wrinkle, Photoaging
- Trial name
- NCT06188338
- Testing
- Fractional picosecond laser treatment followed by daily use of formulations containing MLYAAT-1002®., Fractional picosecond laser treatment followed by daily use of formulations without MLYAAT-1002®
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Botanee Group Co., Ltd.
Anti-aging, Photoaging
A Twelve Week Clinical Study to Evaluate the Efficacy and Tolerability of a Sunscreen Moisturizer SPF 50+
The primary objective of this study is to evaluate the efficacy and tolerance of a moisturizer SPF 50+ when used over a 12-week time period by women with moderate to severe facial photodamage.
- Trial name
- NCT06148558
- Testing
- Sunscreen Moisturizer, Gentle Cleansing Lotion, Facial Moisturizer
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Revision Skincare