Clinical trials: Photodynamic Therapy
Age-Related Macular Degeneration
Lucentis Utilizing Visudyne (LUV Trial) Combination Therapy in the Treatment of Age-Related Macular Degeneration
The PDT/Lucentis trial will be a Phase IV comparative trial comparing the use of combination therapy with ITV ranibizumab and verteporfin PDT to ITV ranibizumab alone in patients with exudative AMD.
- Trial name
- NCT00423189
- Testing
- Ranibizumab (Lucentis), 0.5mg ranibizumab
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- David M. Brown, M.D.
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
HSIL, High Grade Squamous Intraepithelial Lesion, CIN 2
Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2
This study evaluates the efficacy and safety of ALA-PDT versus LEEP in treating cervical HSIL/CIN2, aiming to demonstrate non-inferiority in clinical efficacy.
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesion, CIN 2, HPV (Human Papillomavirus)-Associated, Photodynamic Therapy (PDT)
- Trial name
- PDT for CIN2 (NCT07306260)
- Testing
- ALA-PDT, LEEP surgery
- Where
- 5 sites in China
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy Adults, Plaque, Dental
Photodynamic Treatment in the Management of Residual Biofilm - a Crossover Study
This research introduces a home-use dual-light antibacterial medical device and its possible added value as part of traditional dental self-care.
- Trial name
- NCT06860321
- Testing
- Adjunct antibacterial home-use dual-light medical device, Regular oral self care
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Koite Health Oy
Photodynamic Therapy, Herpes Simplex, Labial
Treatment of Herpes Labialis by Photodynamic Therapy
Lesions of herpes labialis are caused by the herpes simplex virus type 1 (HSV-1) and cause pain and aesthetic compromise. It is characterized by the formation of small vesicles that coalesce and rupture forming extremely painful…
- Trial name
- Herpes (NCT04037475)
- Testing
- photodynamic therapy herpes labialis
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Periodontal Diseases, Chronic Periodontitis
Photodynamic Therapy During Supportive Periodontal Therapy
27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites.
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT02666573
- Testing
- Fotosan 630, CMS Dental, Copenhagen, Denmark, Scaling and root planing
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Periradicular Disease
Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy
The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.
- Trial name
- NCT02555488
- Testing
- diode laser, Methylene blue
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Root Canal Disinfection
Estimate the Effect of aPDT on Root Canal Disinfection
The aim of this study is to compare the clinical effect of traditional root canal disinfection and aPDT on root canal disinfection. And provide the reference for clinical application and experience.
- Trial name
- NCT02929927
- Testing
- Rubber dam isolation, aPDT, 1% iodine tincture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Actinic Dermatosis
Efficacy of Topical Calcipotriol-assisted AFL-PDT in Actinic Keratosis
Vitamin D(Vit D) is a pro-differentiation agent that enhances the accumulation of protoporphyrin IX (PpIX) after MAL(methyl-aminolevulinate) incubation in actinic keratosis and may have significant benefit for the treatment of…
- Trial name
- NCT02976727
- Testing
- Topical Vitamin D (Calcipotriol) application, lidocaine/prilocaine (5%) application, 2940-nm Er:YAG AFL pretreatment
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Pericoronitis
Evaluation of Photodynamic Therapy in Pericoronitis
In order to reduce the chances of systemic dissemination of the infection and the use of antibiotics, it is mandatory to test effective treatments in the initial phase of pericoronitis aiming to avoid the evolution of the…
- Trial name
- pdt (NCT03576105)
- Testing
- irrigation /sterile saline, Conventional methylene blue as photosensitizer, Methylene blue for oral use as photosensitizer
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Tooth Extraction Status Nos
Efficacy of aPDT in Reducing Pain and Swelling Following Molar Extraction Surgery- Blinded Randomized Controlled Clinical Trial
This project aims to evaluate the effect of antimicrobial photodynamic therapy (aPDT) on the reduction of swelling and postoperative pain in lower molar extraction procedures.
- Trial name
- NCT03818906
- Testing
- Molar extraction - Control Group, aPDT + Molar Extraction - Test Group 1, Infrared + Molar Extraction - Test Group 2
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Furcation Defects
Comparison of Bone Graft and Photodynamic Therapy in Class II Furcation
This is a surgical comparative clinical trial which aims to assess class II buccal furcation defects treated with Xenograft alone or preceded by antimicrobial photodynamic therapy.
- Trial name
- NCT06519409
- Testing
- Open flap debridement and photodynamic therapy
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Lichen Amyloidosis
Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians
Efficacy of Methylene blue mediated Photodynamic therapy for primary localized cutaneous amyloidosis treatment in Asians, pilot study.
- Trial name
- NCT03068208
- Testing
- Methylene blue-mediated photodynamic therapy
- Where
- Thailand
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Actinic Keratosis
Efficacy of Iontophoresis-assisted AFL-PDT in Actinic Keratosis
Iontophoresis is a transdermal drug-delivery technique that enhances the transport of ionic species across membranes and may have significant benefit for the treatment of actinic keratosis (AK) by ablative fractional laser-primed…
- Trial name
- NCT02670655
- Testing
- lidocaine/prilocaine (5%) application, 2940-nm Er:YAG AFL pretreatment, MAL application
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Periodontitis, Lasers
The Effect of Adjunctive Therapies in Regenerative Treatment of Stage III Grade C Periodontitis
Anti-infective procedures play a very important role in the success of regenerative surgical treatment of aggressive periodontitis, Grade C periodontitis, which shows the newly named molar-incisor pattern according to the 2017…
- Conditions
- Periodontitis, Lasers, Ozone, Wound Healing
- Trial name
- NCT05447026
- Testing
- Control group, Antimicrobial photodynamic therapy (aPDT) group, LED photobiomodulation group
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Gazi University
Actinic Keratoses
Photodynamic Therapy Incubation Times for Actinic Keratosis
This is a randomized clinical trial evaluating blue light 5-aminolevulinic acid (ALA) photodynamic therapy with different incubation times for the treatment of actinic keratosis.
- Trial name
- NCT03066843
- Testing
- ALA (5-aminolevulinic acid), Blue light therapy
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthcare Associated Infection, Nosocomial Infection
Red Light Photobiomodulation and Topical Disinfectants
The goal of this clinical trial is to evaluate the potential effects of photobiomodulation when used with topical disinfectants in the anterior nares of healthy adults.
- Conditions
- Healthcare Associated Infection, Nosocomial Infection, Surgical Site Infection
- Trial name
- NCT05797818
- Testing
- Methylene Blue Only, Chlorhexidine Gluconate Only, Methylene Blue + Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ondine Biomedical Inc.
Antimicrobial Photodynamic Therapy
The Effect of Antimicrobial Photodynamic Therapy on the Success of Root Canal Treatment
The decontamination of the root canal system from pathological microflora is essential for the success of endodontic treatment. Mechanical instrumentation and irrigation solutions, known as the chemomechanical process, are…
- Trial name
- NCT06634745
- Testing
- Standard Needle Irrigation (SNI), Passive Ultrasonic Irrigation (PUI, EndoActivator (EA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Photodynamic Therapy, Microvesicle Particle
Photodynamic Therapy and Microvesicles
This study is designed to test whether localized photodynamic therapy (PDT) treatment will result in increased skin levels of microvesicle particle (MVP) and if the use of imipramine will counteract PDT generated MVP release.
- Trial name
- NCT03960125
- Testing
- Photodynamic Therapy, 4% Imipramine, Base Cream
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wright State University
Rosacea, Papulopustular Rosacea
Photodynamic Therapy for Papulopustular Rosacea
Rosacea is a chronic inflammatory disorder that is characterized by severe flushing (transient erythema), non-transient erythema, papules, pustules, and telangiectasia.
- Trial name
- NCT02075671
- Testing
- Aminolevulinic acid topical solution 20%, Blu-U Light Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Washington University