Clinical trials: Photodynamic Therapy (PDT)
Basal Cell Carcinoma
Photodynamic Therapy (PDT) With Metvix Cream 160 mg/g Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Cell Carcinoma
Photodynamic therapy (PDT) was the selective destruction of abnormal cells through light activation of a photosensitiser in the presence of oxygen. These cells accumulated more photosensitiser than normal cells.
- Trial name
- NCT00472108
- Testing
- Photodynamic Therapy (PDT), Metvix cream
- Where
- 9 sites in United States
- Volunteers
- 65 people
- Sponsor
- Galderma R&D
Acne Vulgaris
A Double Blinded, Prospective, Randomized, Vehicle Controlled Multi-center Study of Photodynamic Therapy With Visonac® Cream in Patients With Acne Vulgaris
This study is intended to evaluate the efficacy and safety of Visonac Photodynamic Therapy (PDT) in patients with severe acne, score 4 on global IGA scale.
- Trial name
- NCT01347879
- Testing
- Visonac PDT, Vehicle cream with PDT
- Where
- 15 sites in United States
- Volunteers
- 153 people
- Sponsor
- Photocure
Actinic Keratoses
ADL-PDT Under Routine Clinical Conditions in Patients With Actinic Keratosis
The objective of this non-interventional study (NIS) is to gain comprehensive insights into the practicability of ADL-PDT with Metvix® in patients with actinic keratoses under real-world conditions.
- Trial name
- NCT05725213
- Testing
- Metvix® 160 mg/g Creme
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Galderma Laboratorium GmbH
Benign Prostatic Hyperplasia
Dose Escalation Study With QLT0074 for Benign Prostatic Hyperplasia
The primary objective of this study is to assess the safety and tolerance of transurethral photodynamic therapy (PDT) with QLT0074. Secondary objectives are: 1.
- Trial name
- NCT00077012
- Testing
- QLT0074, Photodynamic therapy
- Where
- 7 sites in United States, Canada
- Sponsor
- QLT Inc.
Melanoma (Skin)
Photodynamic Therapy in Treating Patients With Stage III or Stage IV Melanoma
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. Photodynamic therapy may be effective in treating melanoma.
- Trial name
- NCT00007969
- Testing
- Detox-B adjuvant, verteporfin
- Where
- 6 sites in United States
- Sponsor
- QLT Inc.
Port-wine Birthmarks, Port-Wine Stain
A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT
This is a multi-center, randomized, double-blind, vehicle-controlled, and sequential group Phase 2 study. Eligible subjects aged 18 to 75 years old with PWB will receive Hemoporfin PDT or vehicle PDT in 8-week cycles at fixed…
- Conditions
- Port-wine Birthmarks, Port-Wine Stain, Nevus Flammeus
- Trial name
- NCT05171894
- Testing
- Hemopfin+Green Light, Vehicle+Green Light
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Acne Vulgaris
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Moderate to Severe Acne
This multicenter study will be divided into 2 phases. The first phase will be an open label, dose-escalation phase, while the second will be a blinded, randomized, vehicle-controlled, parallel-group, dose-response phase.
- Trial name
- NCT00594425
- Testing
- Methyl aminolevulinate (MAL) PDT
- Where
- 14 sites in United States
- Volunteers
- 150 people
- Sponsor
- Photocure
Prostate Cancer
Study of WST09 in Prostate Cancer After Radiation: Repeat Procedure
This is a multi-centre, phase II, open-label, 12-month clinical trial for patients previously treated with WST09 (Tookad) who have positive prostate biopsies for cancer.
- Trial name
- NCT00305929
- Testing
- Treatment with Tookad VTP
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- STEBA France
Macular Degeneration
VEGF Trap-Eye: Investigation of Efficacy and Safety in Chinese Subjects With Wet AMD (Age-Related Macular Degeneration)
This study will assess the efficacy and safety of intravitreally (IVT), i.e. directly into the eye administered VEGF Trap-Eye compared with photodynamic therapy (PDT) on visual function in Chinese subjects with age-related…
- Trial name
- NCT01482910
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321), Visudyne
- Where
- 14 sites in China
- Volunteers
- 304 people
- Sponsor
- Bayer
Basal Cell Carcinoma
Metvix PDT in Participant With "High Risk" Basal Cell Carcinoma
Photodynamic therapy (PDT) is the selective destruction of abnormal cells through light activation of a photosensitiser in the presence of oxygen. These cells accumulate more photosensitiser than normal cells.
- Trial name
- NCT00473343
- Testing
- Metvix® cream
- Where
- 7 sites in Australia
- Volunteers
- 102 people
- Sponsor
- Galderma R&D
Macular Degeneration
A Study to Compare rhuFab V2 With Verteporfin Photodynamic in Treating Subfoveal Neovascular Macular Degeneration
This is a phase III, multicenter, randomized, double-masked, active treatment-controlled study of intravitreally administered ranibizumab compared with verteporfin (Visudyne) photodynamic therapy (PDT) in treating subfoveal…
- Trial name
- NCT00061594
- Testing
- rhuFab V2 (ranibizumab)
- Where
- 82 sites in United States, Australia and 4 more
- Volunteers
- 426 people
- Sponsor
- Genentech, Inc.
Actinic Keratosis
A Clinical Trial of Topical Photodynamic Therapy With 5-aminolevulinic Acid for the Treatment of Actinic Keratosis
This was a placebo controlled, double blind, randomized phase II dose-response study to evaluate the efficacy and safety of BF-200 ALA (containing the active ingredient 5 - aminolevulinic acid- ALA) used with photodynamic therapy…
- Trial name
- NCT02799030
- Testing
- BF-200 ALA 1%, BF-200 ALA 3%, BF-200 ALA 10%
- Volunteers
- 105 people
- Sponsor
- Biofrontera Bioscience GmbH
Peri-Implantitis, Plaque, Dental
Antibacterial Photodynamic Therapy in the Management of Peri-implantitis
This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term.
- Trial name
- NCT06017817
- Testing
- Lumoral Treatment, Standard oral hygiene instructions, Scaling and root planing (SRP
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Koite Health Oy
Periodontitis, Plaque, Dental
Impact of Regular Home Use of Lumoral Dual-light Photodynamic Therapy on Plaque Control and Gingival Health
This early-stage study is designed to determine the efficacy of the CE-approved, antibacterial, dual-light Lumoral method in periodontitis patients.
- Conditions
- Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05361590
- Testing
- Lumoral device
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Inflamed Gums, Dryness Oral
Regular Antibacterial Photodynamic Therapy on Oral Hygiene in the Elderly 24-hour Care
This study aims to determine the effectiveness of the Lumoral device on oral hygiene, inflammatory load, and dryness of mouth in elderly 24-hour care residents.
- Conditions
- Inflamed Gums, Dryness Oral, Plaque
- Trial name
- NCT05720104
- Testing
- Lumoral Treatment, Standard oral hygiene instructions
- Where
- Sweden
- Sponsor
- Koite Health Oy
Cholangiocarcinoma
PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer
This study will assess the safety and effectiveness of fimaporfin-induced photochemical internalisation (PCI) of gemcitabine complemented by systemic gemcitabine/cisplatin chemotherapy compared to gemcitabine/cisplatin alone, in…
- Trial name
- RELEASE (NCT04099888)
- Testing
- Fimaporfin and Gemcitabine, Gemcitabine/Cisplatin chemotherapy
- Where
- 50 sites in United States, Belgium and 12 more
- Volunteers
- 41 people
- Sponsor
- PCI Biotech AS
Actinic Keratosis
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp
This Phase 3, randomized, multi-center, evaluator-blind, vehicle-controlled study evaluates the efficacy and safety of reformulated Levulan Kerastick (aminolevulinic acid HCl 20%) combined with photodynamic therapy (PDT) for…
- Trial name
- NCT07144345
- Testing
- Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle containing excipients only (VEH) without active ingredient, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E
- Where
- 10 sites in United States
- Volunteers
- 160 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Age-Related Macular Degeneration
Photodynamic Therapy in Occult-Only Lesions (POOL)
Age related macular degeneration is the leading cause of blindness for people over 50 in the western world. Blood vessels which start to grow form a lesion in the back of the eye.
- Trial name
- NCT00135837
- Testing
- Verteporfin for injection
- Where
- Switzerland
- Volunteers
- 202 people
- Sponsor
- Novartis
Acne Vulgaris
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris
In this multicenter study, patients with dark skin and acne vulgaris will be included. The patients will receive treatment with MAL PDT and placebo PDT.
- Trial name
- NCT00673933
- Testing
- Methyl aminolevulinate (MAL) PDT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Photocure
Liver Metastasis, Pelvic Cancer
Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors
This multi-center photodynamic therapy study plans to treat patients with large tumors in any superficial location, sarcoma, tumors of oral/oro-pharyngeal cavity, tumors with extensive pelvic involvement, or liver metastasis.
- Conditions
- Liver Metastasis, Pelvic Cancer, Head and Neck Cancer, Sarcoma
- Trial name
- NCT00028405
- Testing
- LS 11(Taporfin Sodium), Lumaflex Light Delivery Catheter
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Light Sciences LLC