Clinical trials: Photophobia
Cannabis Use, Sleep
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1.
- Conditions
- Cannabis Use, Sleep, Circadian Rhythm
- Trial name
- CASCILS (NCT06743373)
- Testing
- Cannabis Discontinuation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Migraine Headache, Sleep
Light Exposure, Migraine Outcomes, and Sleep Quality
The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.
- Conditions
- Migraine Headache, Sleep, Photophobia
- Trial name
- NCT07476053
- Testing
- Ambient Lighting Condition
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Arizona State University
Photophobia, Visual Impairment
Improving Glare and Visual Comfort for Patients With Visual Impairment
To assess the use of contact lenses with transitions technology to improve glare, light sensitivity and overall visual comfort in patients with visual impairment.
- Conditions
- Photophobia, Visual Impairment, Low Vision
- Trial name
- NCT05829135
- Testing
- Acuvue Oasys with Transitions
- Where
- United States
- Sponsor
- Nova Southeastern University
Photophobia, Traumatic Brain Injury
Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and…
- Conditions
- Photophobia, Traumatic Brain Injury, Migraine
- Trial name
- NCT03694626
- Testing
- Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Light Sensitivity
"Eye Protection After Mydriatic Use for ROP Screening: Impact on Vitals Signs and Pain Scores"
Pupillary dilation induced by mydriatic agents during Retinopathy of Prematurity exams can persist for hours. Despite regular use of eye protection for mydriatic-induced light sensitivity for infants, children and adults, eye…
- Trial name
- NCT01860534
- Testing
- eye covers
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Migraine Disorders, Photophobia
Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Patients With Migraine
Approximately 9% of men and 18% of women suffer from migraine headaches. Almost all migraine sufferers report light sensitivity during a headache.
- Trial name
- NCT01828684
- Testing
- Therapeutic Lens Coating
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Bradley Katz
Photosensitivity
The Role of Spectral Filtering in a Spectrally Adjustable Ocular Photosensitivity Analyzer
This is a 6-visit, single-center, non-dispensing, randomized, single-masked, 5×5 crossover study. Subjects will participate in 6 scheduled over the duration of approximately 10.5 months.
- Trial name
- NCT04811079
- Testing
- 419 nm Spectacle Filter, 437 nm Spectacle Filter, 456 nm Spectacle Filter
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Mild Traumatic Brain Injury, Photophobia
Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury
The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in…
- Trial name
- NCT06109909
- Testing
- Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Migraine
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to <18 years with episodic migraine.
- Trial name
- NCT05156398
- Testing
- Rimegepant
- Where
- 93 sites in United States, Canada and 5 more
- Volunteers
- 640 people
- Sponsor
- Pfizer
Photophobia
Comparison Between Spectacles and Contact Lenses
Many people suffer from migraine headaches, some more so than others and a common trigger/complaint is light sensitivity, or photophobia1.
- Trial name
- NCT06905912
- Testing
- Biomedics55 Premier contact lenses, and Altius Tinted Contact Lenses
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Migraine Disorders, Photophobia
Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Child and Adolescent Patients With Migraine
The purpose of this study is to determine if a special coating, applied to the surface of glasses can reduce the frequency and severity of migraine headaches in children and adolescents.
- Trial name
- NCT01942486
- Testing
- Investigational Coating
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Utah
Migraine, Photophobia
Impact of Optimized White Light on Visual Discomfort, Headache Intensity, and Cognitive Performance Among Those With Migraine
The goal of this research is to study how effective an optimized white light is for improving visual comfort and reducing migraine symptoms.
- Conditions
- Migraine, Photophobia, Cognitive Function Assessment, Headache
- Trial name
- NCT07898722
- Testing
- Optimized Ambient White Light, Conventional White Light
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Myopia
Side Effects of Atropine (SEA) Study
This study will perform several objective and subjective measurements of the eye and vision before and after a week of using 0.01% concentration atropine drops.
- Trial name
- SEA (NCT03593044)
- Testing
- 0.01% concentration atropine drops
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Jeffrey J. Walline, OD PhD
Acute Treatment of Migraine
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of migraine in children and adolescents (≥ 6 to < 18 years of age).
- Trial name
- NCT04743141
- Testing
- Rimegepant (PF-07899801)
- Where
- 124 sites in United States, Poland and 1 more
- Volunteers
- 600 people
- Sponsor
- Pfizer
Migraine
Validation of a Questionnaire for Allodynia in Migraine.
Migraine is very frequent (15% of the general population). During attacks, many subjects with migraine have allodynia (pain induced by normally non-painful stimuli), photophobia (hypersensitivity to light), phonophobia…
- Trial name
- Q-MIGAL (NCT04580641)
- Testing
- Questionnaire
- Where
- 14 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Light Sensitivity
Eye Movement Behaviour and Pupil Size in Natural Outdoor and Indoor Scenes
In this study, the researchers will be using eye tracking and detailed lighting measurements to understand how different types of indoor and outdoor lighting affect the eye movements and pupil sizes of our participants.
- Trial name
- NCT05971238
- Testing
- Indoor vs. outdoor scenes
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Concussion, Mild, Photophobia
Use of Tinted Contact Lenses for Concussion-Related Light Sensitivity
The purpose of this study is to gather pilot data on the effectiveness of daily disposable tinted contact lenses in reducing photophobia (light sensitivity) following a concussion, with the goal of facilitating the return to work…
- Conditions
- Concussion, Mild, Photophobia, Contact Lens
- Trial name
- NCT07223086
- Testing
- Narrow band (tinted) contact lenses, broad band (clear) contact lenses
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye, Contact Lens Acute Red Eye
Performance and Tolerability of the Medical Device LACRIACT
The goal of this study is testing LACRIACT® eye drops, a medical device, to see how well it works and if people can use it safely.
- Conditions
- Dry Eye, Contact Lens Acute Red Eye, Photophobia, Discomfort
- Trial name
- NCT06159569
- Testing
- LACRIACT
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Laboratórios Baldacci S.A
Migraine
Study of Quality of Life in Subjects With Chronic or High-frequency Episodic Migraine and Associated Comorbidities Treated With Erenumab
Migraine is a very common, neurological disorder, characterized by recurrent episodes of headache, potential progression to more frequent and severe attack patterns, and associated symptoms.
- Trial name
- COMIG (NCT04114630)
- Testing
- erenumab 70mg/mL
- Where
- 27 sites in Spain
- Sponsor
- Novartis Pharmaceuticals
Visual Snow Syndrome, Trailing Phenomenon
Mindfulness Based Cognitive Therapy Modified for Visual Symptoms (MBCT-vision)
This is a research study on Mindfulness-Based Cognitive Therapy for visual symptoms (MBCT-vision), to treat patients with debilitating symptoms of visual snow (VS) and is associated visual symptoms, severe light sensitivity (i.e.
- Conditions
- Visual Snow Syndrome, Trailing Phenomenon, Photophobia, Visual Aura
- Trial name
- MBCT-vision (NCT04184726)
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust